Increased apoptosis and decreased proliferation of colorectal cancer cells using insulin-like growth factor binding protein-4 gene delivered locally by gene transfer

Colorectal Disease

Volumn 9, Issue 7, 2007, Pages 625-631

  Durai, R ^a   Yang, S Y ^a   Sales, K M ^a   Seifalian, A M ^a   Goldspink, G ^a   Winslet, M C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; Colon cancer; Genetherapy; Insulin like growth factor; Insulin like growth factor binding protein 4; Mitosis

Indexed keywords

COMPLEMENTARY DNA; SOMATOMEDIN BINDING PROTEIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GENE THERAPY; CANCER SIZE; CANCER TISSUE; CELL PROLIFERATION; CELL STRAIN HT29; COLORECTAL CANCER; CONTROLLED STUDY; EXPRESSION VECTOR; GENE OVEREXPRESSION; GENE TRANSFER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MITOSIS INHIBITION; MOUSE; NICK END LABELING; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; TUMOR NECROSIS;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; MICE; MICE, NUDE; MITOSIS; PROTEIN BINDING;

EID: 34547902841     PISSN: 14628910     EISSN: 14631318     Source Type: Journal    
DOI: 10.1111/j.1463-1318.2006.01190.x     Document Type: Article

References (24)

1. Khandwala HM, McCutcheon IE, Flyvbjerg A, Friend KE. The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev 2000; 21: 215-44.
2. Singh P, Dai B, Dhruva B, Widen SG. Episomal expression of sense and antisense insulin-like growth factor (IGF)-binding protein-4 complementary DNA alters the mitogenic response of a human colon cancer cell line (HT-29) by mechanisms that are independent of and dependent upon IGF-I. Cancer Res 1994; 54: 6563-70.
3. Adachi Y, Lee CT, Coffee K et al. Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines. Gastroenterology 2002; 123: 1191-204.
4. Zhou R, Diehl D, Hoeflich A, Lahm H, Wolf E. IGF-binding protein-4: biochemical characteristics and functional consequences. J Endocrinol 2003; 178: 177-93.
5. Yu Z, Li W, Liu F. Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett 2004; 215: 159-66.
6. Robbins S, Cotran R, Kumar V. (1995) Cellular Injury and Cellular Death. Pocket Companian to Robbins Pathologic Basis of Disease. pp. 8-9. W.B. Saunders Company, Philadelphia.
7. Zhou R, Flaswinkel H, Schneider MR et al. Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice. J Mol Endocrinol 2004; 32: 349-64.
8. Gajewska M, Motyl T. IGF-binding proteins mediate TGF-beta1-induced apoptosis in bovine mammary epithelial BME-UV1 cells. Comp Biochem Physiol C Toxicol Pharmacol 2004; 139: 65-75.
9. Diehl D, Hoeflich A, Wolf E, Lahm H. Insulin-like growth factor (IGF)-binding protein-4 inhibits colony formation of colorectal cancer cells by IGF-independent mechanisms. Cancer Res 2004; 64: 1600-3.
10. Damon SE, Maddison L, Ware JL, Plymate SR. Overexpression of an inhibitory insulin-like growth factor binding protein (IGFBP), IGFBP-4, delays onset of prostate tumor formation. Endocrinology 1998; 139: 3456-64.
11. Drivdahl RH, Sprenger C, Trimm K, Plymate SR. Inhibition of growth and increased expression of insulin-like growth factor-binding protein-3 (IGFBP-3) and -6 in prostate cancer cells stably transfected with antisense IGFBP-4 complementary deoxyribonucleic acid. Endocrinology 2001; 142: 1990-8.
12. Culouscou JM, Shoyab M. Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein. Cancer Res 1991; 51: 2813-9.
13. Sawaoka H, Kawano S, Tsuji S et al. Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice. Am J Physiol 1998; 274: G1061-7.
14. Takei Y, Marzi I, Kauffman FC et al. Increase in survival time of liver transplants by protease inhibitors and a calcium channel blocker, nisoldipine. Transplantation 1990; 50: 14-20.
15. Mills SJ, Mathers JC, Chapman PD, Burn J, Gunn A. Colonic crypt cell proliferation state assessed by whole crypt microdissection in sporadic neoplasia and familial adenomatous polyposis. Gut 2001; 48: 41-6.
16. Gavrieli Y, Sherman Y, Ben Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
17. Bruns CJ, Liu W, Davis DW et al. Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases. Cancer 2000; 89: 488-99.
18. Singh P, Dai B, Yallampalli U, Lu X, Schroy PC. Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: Role of IGF-II. Endocrinology 1996; 137: 1764-74.
19. Novo FJ, Gorecki DC, Goldspink G, MacDermot KD. Gene transfer and expression of human alpha-galactosidase from mouse muscle in vitro and in vivo. Gene Ther 1997; 4: 488-92.
20. Thomas LN, Wright AS, Lazier CB, Cohen P, Rittmaster RS. Prostatic involution in men taking finasteride is associated with elevated levels of insulin-like growth factor-binding proteins (IGFBPs)-2, -4, and -5. Prostate 2000; 42: 203-10.
21. Bruyninx M, Ammar H, Reiter E, Cornet A, Closset J. Genes upregulated during castration-induced rat prostatic apoptosis: Cloning and characterization of new cDNAs. BJU Int 2000; 85: 1134-42.
22. Chen ZY, Istfan NW. Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. Prostaglandins Leukot Essent Fatty Acids 2000; 63: 301-8.
23. Remacle-Bonnet MM, Garrouste FL, Heller S et al. Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. Cancer Res 2000; 60: 2007-17.
24. Reinmuth N, Liu W, Fan F et al. Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer. Clin Cancer Res 2002; 8: 3259-69.