Adipokine expression and secretion by canine adipocytes: Stimulation of inflammatory adipokine production by LPS and TNFα

Pflugers Archiv European Journal of Physiology

Volumn 460, Issue 3, 2010, Pages 603-616

  Ryan, Vivien H ^a   German, Alexander J ^a   Wood, I Stuart ^a   Hunter, Leif ^a   Morris, Penelope ^b   Trayhurn, Paul ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b WALTHAM CENTRE FOR PET NUTRITION   (United Kingdom)

Author keywords

Adipocytes; Adipokines; Adipose tissue; Dog; Inflammation

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; DEXAMETHASONE; INTERLEUKIN 6; LECTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; ANTIINFLAMMATORY AGENT; CYTOKINE; LEPTIN; LIPOPOLYSACCHARIDE;

ADIPOCYTE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN EXPRESSION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; ANIMAL; CELL CULTURE; DOG; DRUG EFFECTS; METABOLISM; SECRETION (PROCESS);

ADIPOCYTES; ADIPONECTIN; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CYTOKINES; DEXAMETHASONE; DOGS; FEMALE; HYPOGLYCEMIC AGENTS; LEPTIN; LIPOPOLYSACCHARIDES; MALE; THIAZOLIDINEDIONES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955468067     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-010-0845-x     Document Type: Article

References (57)

1. AH Berg TP Combs X Du M Brownlee PE Scherer 2001 The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat Med 7 947 953 10.1038/90992 1:CAS:528:DC%2BD3MXlvVOktLw%3D 11479628 (Pubitemid 32756433)
2. BL Brunson Q Zhong KJ Clarke D Bedi TD Braden E van Santen RL Judd 2007 Serum concentrations of adiponectin and characterization of adiponectin protein complexes in dogs Am J Vet Res 68 57 62 10.2460/ajvr.68.1.57 1:CAS:528:DC%2BD2sXhsVOns70%3D 17199419 (Pubitemid 46157597)
3. RF Butterwick AJ Hawthorne 1998 Advances in dietary management of obesity in dogs and cats J Nutr 128 2771S 2775S 1:STN:280:DyaK1M%2Fos1Gqtg%3D%3D 9868263
4. G Chinetti JC Fruchart B Staels 2003 Peroxisome proliferator-activated receptors and inflammation: from basic science to clinical applications Int J Obesity 27 Suppl 3 S41 S45 10.1038/sj.ijo.0802499 1:CAS:528:DC%2BD2cXls1Gr
5. Connover WJ (1999) Practical nonparametric statistics, 3rd edn. Wiley, New York
6. DE Critchlow MA Fligner 1991 On distribution-free multiple comparisons in the one-way analysis of variance Commun Statist-Theory Meth 20 127 139 10.1080/03610929108830487
7. P De Vos AM Lefebvre SG Miller M Guerre-Millo K Wong R Saladin LG Hamann B Staels MR Briggs J Auwerx 1996 Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor γ J Clin Invest 98 1004 1009 10.1172/JCI118860 8770873
8. P De Vos R Saladin J Auwerx B Staels 1995 Induction of ob gene-expression by corticosteroids is accompanied by body-weight loss and reduced food-intake J Biol Chem 270 15958 15961 10.1074/jbc.270.15.8971 7608151
9. M Degawa-Yamauchi KA Moss JE Bovenkerk SS Shankar CL Morrison CJ Lelliott A Vidal-Puig RM Jones RV Considine 2005 Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor α Obesity Res 13 662 669 10.1038/oby.2005.74 1:CAS:528: DC%2BD2MXlsFSkurc%3D
10. I Eisele IS Wood AJ German L Hunter P Trayhurn 2005 Adipokine gene expression in dog adipose tissues and dog white adipocytes differentiated in primary culture Horm Metab Res 37 474 481 10.1055/s-2005-870325 1:CAS:528:DC%2BD2MXhtVakt7%2FP 16138259 (Pubitemid 41306396)
11. M Fasshauer J Klein S Neumann M Eszlinger R Paschke 2002 Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes Biochem Biophys Res Commun 290 1084 1089 10.1006/bbrc.2001.6307 1:CAS:528:DC%2BD38XksV2jtA%3D%3D 11798186 (Pubitemid 34687474)
12. AJ German 2006 The growing problem of obesity in dogs and cats J Nutr 136 1940S 1946 1:CAS:528:DC%2BD28Xmtlyhs70%3D 16772464
13. AJ German M Hervera L Hunter SL Holden PJ Morris V Biourge P Trayhurn 2009 Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs Domest Anim Endocrinol 37 214 226 10.1016/j.domaniend.2009.07.001 1:CAS:528:DC%2BD1MXht1Cqsr%2FM 19674864
14. MF Gregor GS Hotamisligil 2007 Adipocyte stress: the endoplasmic reticulum and metabolic disease J Lipid Res 48 1905 1914 10.1194/jlr.R700007- JLR200 1:CAS:528:DC%2BD2sXpslOjurg%3D 17699733 (Pubitemid 47360610)
15. M Hoene C Weigert 2008 The role of interleukin-6 in insulin resistance, body fat distribution and energy balance Obesity Rev 9 20 29 1:CAS:528:DC%2BD1cXisFGitb0%3D
16. M Hoenig 2002 Comparative aspects of diabetes mellitus in dogs and cats Mol Cell Endocrinol 197 221 229 10.1016/S0303-7207(02)00264-2 1:CAS:528:DC%2BD38XosFCmsbw%3D 12431816 (Pubitemid 35304796)
17. GS Hotamisligil 2006 Inflammation and metabolic disorders Nature 444 860 867 10.1038/nature05485 1:CAS:528:DC%2BD28XhtlShtrzK 17167474 (Pubitemid 46024993)
18. GS Hotamisligil 2009 Inflammation and endoplasmic reticulum stress in obesity and diabetes Int J Obesity 32 S52 S54 10.1038/ijo.2008.238
19. GS Hotamisligil NS Shargill BM Spiegelman 1993 Adipose expression of tumor necrosis factor-α- direct role in obesity-linked insulin resistance Science 259 87 91 10.1126/science.7678183 1:CAS:528:DyaK3sXnvFaitw%3D%3D 7678183
20. K Ishioka A Omachi M Sagawa H Shibata T Honjoh K Kimura M Saito 2006 Canine adiponectin: cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity Res Vet Sci 80 127 132 10.1016/j.rvsc.2005.05. 011 1:CAS:528:DC%2BD2MXht12qtb7M 16051287 (Pubitemid 43033445)
21. SE Kahn RL Hull KM Utzschneider 2006 Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 444 840 846 10.1038/nature05482 1:CAS:528:DC%2BD28XhtlShtrzP 17167471 (Pubitemid 46024990)
22. CB Kallen MA Lazar 1996 Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes Proc Natl Acad Sci USA 93 5793 5796 10.1073/pnas.93.12.5793 1:CAS:528:DyaK28Xjs1Kqu7s%3D 8650171 (Pubitemid 26191315)
23. H Kanda S Tateya Y Tamori K Kotani KI Hiasa R Kitazawa S Kitazawa H Miyachi S Maeda K Egashira M Kasuga 2006 MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity J Clin Invest 116 1494 1505 10.1172/JCI26498 1:CAS:528: DC%2BD28XlsFWrtLo%3D 16691291
24. TG Kirchgessner K Uysal SM Wiesbrock MW Marino GS Hotamisligil 1997 Tumor necrosis factor-α contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes J Clin Invest 100 2777 2782 10.1172/JCI119824 1:CAS:528:DyaK2sXotVejsrg%3D 9389742
25. EF Kirkness V Bafna AL Halpern S Levy K Remington DB Rusch AL Delcher M Pop W Wang CM Fraser JC Venter 2003 The dog genome: survey sequencing and comparative analysis Science 301 1898 1903 10.1126/science.1086432 14512627 (Pubitemid 37221394)
26. D Langin P Arner 2006 Importance of TNFα and neutral lipases in human adipose tissue lipolysis Trends Endocrinol Metab 17 314 320 10.1016/j.tem.2006.08.003 1:CAS:528:DC%2BD28XpvV2lur0%3D 16938460 (Pubitemid 44419491)
27. Y Lin H Lee AH Berg MP Lisanti L Shapiro PE Scherer 2000 The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes J Biol Chem 275 24255 24263 10.1074/jbc.M002137200 1:CAS:528:DC%2BD3cXlslyqtbY%3D 10823826 (Pubitemid 30626513)
28. K Lindblad-Toh CM Wade TS Mikkelsen EK Karlsson DB Jaffe M Kamal M Clamp JL Chang EJ Kulbokas 3rd MC Zody E Mauceli X Xie M Breen RK Wayne EA Ostrander CP Ponting F Galibert DR Smith PJ DeJong E Kirkness P Alvarez T Biagi W Brockman J Butler CW Chin A Cook J Cuff MJ Daly D DeCaprio S Gnerre M Grabherr M Kellis M Kleber C Bardeleben L Goodstadt A Heger C Hitte L Kim KP Koepfli HG Parker JP Pollinger SM Searle NB Sutter R Thomas C Webber J Baldwin A Abebe A Abouelleil L Aftuck M Ait-Zahra T Aldredge N Allen P An S Anderson C Antoine H Arachchi A Aslam L Ayotte P Bachantsang A Barry T Bayul M Benamara A Berlin D Bessette B Blitshteyn T Bloom J Blye L Boguslavskiy C Bonnet B Boukhgalter A Brown P Cahill N Calixte J Camarata Y Cheshatsang J Chu M Citroen A Collymore P Cooke T Dawoe R Daza K Decktor S DeGray N Dhargay K Dooley P Dorje K Dorjee L Dorris N Duffey A Dupes O Egbiremolen R Elong J Falk A Farina S Faro D Ferguson P Ferreira S Fisher M FitzGerald K Foley C Foley A Franke D Friedrich D Gage M Garber G Gearin G Giannoukos T Goode A Goyette J Graham E Grandbois K Gyaltsen N Hafez D Hagopian B Hagos J Hall C Healy R Hegarty T Honan A Horn N Houde L Hughes L Hunnicutt M Husby B Jester C Jones A Kamat B Kanga C Kells D Khazanovich AC Kieu P Kisner M Kumar K Lance T Landers M Lara W Lee JP Leger N Lennon L Leuper S LeVine J Liu X Liu Y Lokyitsang T Lokyitsang A Lui J Macdonald J Major R Marabella K Maru C Matthews S McDonough T Mehta J Meldrim A Melnikov L Meneus A Mihalev T Mihova K Miller R Mittelman V Mlenga L Mulrain G Munson A Navidi J Naylor T Nguyen N Nguyen C Nguyen R Nicol N Norbu C Norbu N Novod T Nyima P Olandt B O'Neill K O'Neill S Osman L Oyono C Patti D Perrin P Phunkhang F Pierre M Priest A Rachupka S Raghuraman R Rameau V Ray C Raymond F Rege C Rise J Rogers P Rogov J Sahalie S Settipalli T Sharpe T Shea M Sheehan N Sherpa J Shi D Shih J Sloan C Smith T Sparrow J Stalker N Stange-Thomann S Stavropoulos C Stone S Stone S Sykes P Tchuinga P Tenzing S Tesfaye D Thoulutsang Y Thoulutsang K Topham I Topping T Tsamla H Vassiliev V Venkataraman A Vo T Wangchuk T Wangdi M Weiand J Wilkinson A Wilson S Yadav S Yang X Yang G Young Q Yu J Zainoun L Zembek A Zimmer ES Lander 2005 Genome sequence, comparative analysis and haplotype structure of the domestic dog Nature 438 803 819 10.1038/nature04338 1:CAS:528:DC%2BD2MXht1yns7%2FF 16341006 (Pubitemid 41753059)
29. ΔΔct method Methods 25 402 408 10.1006/meth.2001.1262 1:CAS:528:DC%2BD38XhtFelt7s%3D 11846609 (Pubitemid 34164012)
30. H Masuzaki Y Ogawa K Hosoda T Miyawaki I Hanaoka J Hiraoka A Yasuno H Nishimura Y Yoshimasa S Nishi K Nakao 1997 Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing's syndrome J Clin Endocrinol Metab 82 2542 2547 10.1210/jc.82.8.2542 1:CAS:528:DyaK2sXltFGqsbo%3D 9253331 (Pubitemid 27337870)
31. CT Montague JB Prins L Sanders JE Digby S OR 1997 Depot- and sex-specific differences in human leptin mRNA expression: Implications for the control of regional fat distribution Diabetes 46 342 347 10.2337/diabetes.46.3.342 1:CAS:528:DyaK2sXhsVGnu74%3D 9032087
32. CT Montague JB Prins L Sanders JL Zhang CP Sewter J Digby CD Byrne S O'Rahilly 1998 Depot-related gene expression in human subcutaneous and omental adipocytes Diabetes 47 1384 1391 10.2337/diabetes.47.9.1384 1:CAS:528: DyaK1cXls12rs7Y%3D 9726225
33. H Motoshima X Wu MK Sinha VE Hardy EL Rosato DJ Barbot FE Rosato BJ Goldstein 2002 Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone J Clin Endocrinol Metab 87 5662 5667 10.1210/jc.2002-020635 1:CAS:528: DC%2BD38XpslWnurk%3D 12466369 (Pubitemid 36034375)
34. N Ouchi S Kihara Y Arita K Maeda H Kuriyama Y Okamoto K Hotta M Nishida M Takahashi T Nakamura S Yamashita T Funahashi Y Matsuzawa 1999 Novel modulator for endothelial adhesion molecules-Adipocyte-derived plasma protein adiponectin Circulation 100 2473 2476 1:CAS:528:DC%2BD3cXjvFSrsA%3D%3D 10604883
35. N Ouchi S Kihara Y Arita Y Okamoto K Maeda H Kuriyama K Hotta M Nishida M Takahashi M Muraguchi Y Ohmoto T Nakamura S Yamashita T Funahashi Y Matsuzawa 2000 Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappa B signaling through a cAMP-dependent pathway Circulation 102 1296 1301 1:CAS:528:DC%2BD3cXntFCgt7g%3D 10982546
36. MR Peeraully JR Jenkins P Trayhurn 2004 NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines Am J Physiol Endocrinol Metab 287 E331 E339 10.1152/ajpendo.00076.2004 1:CAS:528:DC%2BD2cXmvVKntLc%3D 15100092 (Pubitemid 38943901)
37. JB Prins CU Niesler CM Winterford NA Bright K Siddle S Orahilly NI Walker DP Cameron 1997 Tumor necrosis factor-α induces apoptosis of human adipose cells Diabetes 46 1939 1944 10.2337/diabetes.46.12.1939 1:CAS:528:DyaK2sXnslGqtrk%3D 9392477
38. MJ Radin LC Sharkey BJ Holycross 2009 Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses Vet Clin Pathol 38 136 156 10.1111/j.1939-165X.2009.00133.x 19392760
39. MW Rajala PE Scherer 2003 The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis Endocrinology 144 3765 3773 10.1210/en.2003-0580 1:CAS:528:DC%2BD3sXmvFWkurg%3D 12933646 (Pubitemid 37088727)
40. ED Rosen BM Spiegelman 2006 Adipocytes as regulators of energy balance and glucose homeostasis Nature 444 847 853 10.1038/nature05483 1:CAS:528:DC%2BD28XhtlShtrzI 17167472 (Pubitemid 46024991)
41. V Rotter I Nagaev U Smith 2003 Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-α, overexpressed in human fat cells from insulin-resistant subjects J Biol Chem 278 45777 45784 10.1074/jbc.M301977200 1:CAS:528: DC%2BD3sXosl2itrs%3D 12952969 (Pubitemid 37432722)
42. VH Ryan AJ German IS Wood L Hunter P Morris P Trayhurn 2008 NGF gene expression and secretion by canine adipocytes in primary culture: upregulation by the inflammatory mediators LPS and TNFα Horm Metab Res 40 861 868 10.1055/s-0028-1083782 1:CAS:528:DC%2BD1MXhslehtrc%3D 18792883
43. M Ryden E Arvidsson L Blomqvist L Perbeck A Dicker P Arner 2004 Targets for TNF-α-induced lipolysis in human adipocytes Biochem Biophys Res Commun 318 168 175 10.1016/j.bbrc.2004.04.010 1:CAS:528:DC%2BD2cXjsVWlt7k%3D 15110769 (Pubitemid 38526261)
44. P Sartipy DJ Loskutoff 2003 Monocyte chemoattractant protein 1 in obesity and insulin resistance Proc Natl Acad Sci USA 100 7265 7270 10.1073/pnas.1133870100 1:CAS:528:DC%2BD3sXkslOms70%3D 12756299 (Pubitemid 36706427)
45. B Staels J-C Fruchart 2005 Therapeutic roles of peroxisome proliferator-activated receptor agonists Diabetes 54 2460 2470 10.2337/diabetes.54.8.2460 1:CAS:528:DC%2BD2MXnt1ynt7Y%3D 16046315 (Pubitemid 41134276)
46. J Sutinen K Kannisto E Korsheninnikova RM Fisher E Ehrenborg T Nyman A Virkamaki T Funahashi Y Matsuzawa H Vidal A Hamsten H Yki-Jarvinen 2004 Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy Am J Physiol Endocrinol Metab 286 E941 E949 10.1152/ajpendo.00490.2003 1:CAS:528:DC%2BD2cXkvFGjsL0%3D 14749206 (Pubitemid 38668816)
47. P Trayhurn JH Beattie 2001 Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ Proc Nutr Soc 60 329 339 10.1079/PNS200194 1:CAS:528:DC%2BD3MXmslyhu7s%3D 11681807
48. P Trayhurn IS Wood 2004 Adipokines: inflammation and the pleiotropic role of white adipose tissue Br J Nutr 92 347 355 10.1079/BJN20041213 1:CAS:528:DC%2BD2cXosV2gtL0%3D 15469638 (Pubitemid 40277057)
49. B Wang JR Jenkins P Trayhurn 2005 Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-α Am J Physiol Endocrinol Metab 288 E731 E740 10.1152/ajpendo.00475.2004 1:CAS:528:DC%2BD2MXjtlyjsrY%3D 15562246 (Pubitemid 40397208)
50. B Wang P Trayhurn 2006 Acute and prolonged effects of TNF-α on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture Pflügers Archiv Eur J Physiol 452 418 427 10.1007/s00424-006-0055-8 1:CAS:528:DC%2BD28XmtFGqsb4%3D (Pubitemid 43962051)
51. SP Weisberg D McCann M Desai M Rosenbaum RL Leibel AW Ferrante Jr 2003 Obesity is associated with macrophage accumulation in adipose tissue J Clin Invest 112 1796 1808 1:CAS:528:DC%2BD3sXhtVSmtLvO 14679176
52. P Wu K Sato S Yukawa Y Hikasa K Kagota 2001 Differentiation of stromal-vascular cells isolated from canine adipose tissues in primary culture J Vet Med Sci 63 17 23 10.1292/jvms.63.17 1:CAS:528:DC%2BD3MXhtFCnt7k%3D 11217057 (Pubitemid 33639686)
53. H Xu GT Barnes Q Yang G Tan D Yang CJ Chou J Sole A Nichols JS Ross LA Tartaglia H Chen 2003 Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J Clin Invest 112 1821 1830 1:CAS:528:DC%2BD3sXhtVSmtLvI 14679177
54. T Yamauchi J Kamon H Waki Y Terauchi N Kubota K Hara Y Mori T Ide K Murakami N Tsuboyama-Kasaoka O Ezaki Y Akanuma O Gavrilova C Vinson ML Reitman H Kagechika K Shudo M Yoda Y Nakano K Tobe R Nagai S Kimura M Tomita P Froguel T Kadowaki 2001 The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nat Med 7 941 946 10.1038/90984 1:CAS:528:DC%2BD3MXlvVOkt7o%3D 11479627 (Pubitemid 32756432)
55. T Yoshida M Hayashi T Monkawa T Saruta 1996 Regulation of obese mRNA expression by hormonal factors in primary cultures of rat adipocytes Eur J Endocrinol 135 619 625 10.1530/eje.0.1350619 1:CAS:528:DyaK28Xnt1Kiuro%3D 8980166
56. JS Yudkin 2003 Adipose tissue, insulin action and vascular disease: inflammatory signals Int J Obesity 27 Suppl 3 S25 S28 10.1038/sj.ijo.0802496 1:CAS:528:DC%2BD2cXls1Gl
57. HH Zhang S Kumar AH Barnett MC Eggo 2000 Tumour necrosis factor-α exerts dual effects on human adipose leptin synthesis and release Mol Cell Endocrinol 159 79 88 10.1016/S0303-7207(99)00194-X 1:CAS:528: DC%2BD3cXht1Grurk%3D 10687854 (Pubitemid 30067642)