The trans influence in the modulation of platinum anticancer agent biology: The effect of nitrite leaving group on aquation, reactions with S-nucleophiles and DNA binding of dinuclear and trinuclear compounds

Chemistry - A European Journal

Volumn 16, Issue 30, 2010, Pages 9175-9185

  Montero, Eva I ^a   Zhang, Junyong ^b   Moniodis, Joseph J ^b   Berners Price, Susan J ^b,c   Farrell, Nicholas P ^a,c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c GRIFFITH UNIVERSITY   (Australia)

Author keywords

Amino acids; Antitumor agents; Bioinorganic chemistry; DNA; Platinum

Indexed keywords

ANTI-CANCER AGENTS; ANTI-TUMOR AGENTS; ANTITUMOR COMPOUNDS; AQUATION; AQUATION REACTIONS; BIOINORGANIC CHEMISTRY; BIOLOGICAL PROPERTIES; DIFFERENT MECHANISMS; DINUCLEAR; DNA BINDING; GLUTATHIONES; HSQC NMR; LEAVING GROUPS; NITRITE ION; NITRITO GROUP; PHYSIOLOGICAL PH; PLATINUM ANTITUMOR AGENT; REACTION PATHWAYS; TRANS INFLUENCE;

AMINO ACIDS; BIOCHEMISTRY; CHEMICAL REACTIVITY; CHLORINE COMPOUNDS; COMPLEXATION; DNA; GENES; GROUP TECHNOLOGY; ISOMERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOPHILES; ORGANIC ACIDS; PH EFFECTS; PLATINUM; SULFUR; SYNTHESIS (CHEMICAL);

COORDINATION REACTIONS;

ANTINEOPLASTIC AGENT; DNA; GLUTATHIONE; NITRITE; PLATINUM COMPLEX;

ARTICLE; CHEMISTRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; DNA; GLUTATHIONE; MAGNETIC RESONANCE SPECTROSCOPY; NITRITES; ORGANOPLATINUM COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955464785     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200903578     Document Type: Article

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