Oxygen and glucose deprivation in an organotypic hippocampal slice model of the developing rat brain: The effects on N-methyl-d-aspartate subunit composition

Anesthesia and Analgesia

Volumn 109, Issue 1, 2009, Pages 205-210

  Wise Faberowski, Lisa ^a   Robinson, Prairie Neeley ^a   Rich, Sarah ^a   Warner, David S ^b  

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; GLUCOSE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NR2A NMDA RECEPTOR; NR2B NMDA RECEPTOR; OXYGEN; PROTEIN SUBUNIT;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; GLUCOSE BRAIN LEVEL; HIPPOCAMPUS; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT; SPRAGUE DAWLEY RAT; TISSUE CULTURE; TISSUE SURVIVAL; ANIMAL; BIOSYNTHESIS; CELL DEATH; CELL HYPOXIA; COMPARATIVE STUDY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; CELL DEATH; CELL HYPOXIA; GLUCOSE; HIPPOCAMPUS; NEUROGENESIS; ORGAN CULTURE TECHNIQUES; OXYGEN; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 67650672128     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e3181a27e37     Document Type: Article

References (41)

1. Forrest D, Yusaki M, Soares HD, Ng L, Luk DC, Sheng M, Stewart CL, Morgan JI, Conner JA, Curran T. Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death. Neuron 1994;13:325-38
2. Hardingham GE, Bading H. The yin and the yang of NMDA receptor signaling. Trends Neurosci 2003;26:81-9
3. Cull-Candy S, Brickley S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 2001;11:327-35
4. Cull-Candy S, Leszkiewicz DN. Role of distinct NMDA receptor subtypes in central synapses. Sci STKE 2004;re16
5. Durand GM, Kovalchuk Y, Konnerth A. Long-term potentiation and functional synapse induction in developing hippocampus. Nature 1996;381:71-5
6. Moyner H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 1994;12:529-40
7. Sheng M, Cummings J, Roldan LA, Jan YN, Jan LY. Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 1994;368:144-7
8. Groc L, Heine M, Cousins SL. NMDA receptor surface mobility depends on NR2A-2B subunits. Proc Natl Acad Sci U S A 2006;103:18769-74
9. Massey PV, Johnson BE, Moult PR, Auberson YP, Brown MW, Molnar E, Collingridge GL, Bashir ZI. Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and depression. J Neurosci 2004;24:7821-8
10. Babb TL, Mikuni N, Najm I, Wylie C, Olive M, Dollar C, MacLennan H. Pre- and postnatal expressions of NMDA receptors 1 and 2B subunit proteins in the normal rat cortex. Epilepsy Res 2005;64:23-30
11. Bear MF, Malenka RC. Synaptic plasticity: LTP and LTD. Curr Opin Neurobiol 1994;4:389-99
12. Liu L, Wong TP, Pozza MF, Lingnehoehl K, Wang Y, Sheng M, Auberson YP, Wang YT. Role NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 2004;304:1021-4
13. Watanabe M, Inoue Y, Sakimura K, Mishina M. Developmental changes in distribution of NMDA receptor channel subunit mRNA's. Neuroreport 1992;3:1138-40
14. Gurd JW, Bissoon N, Beesley PW, Nakazawa T, Yamamoto T, Vannucci SJ. Differential effects of hypoxia-ischemia on subunit expression and tyrosine phosphorylation of the NMDA receptor in 7- and 21-day old rats. J Neurochem 2002;82:848-56
15. Ben-Ari Y. Basic developmental rules and their implications for epilepsy in the immature brain. Epileptic Disord 2006;8:91-102
16. Ikonomidou C, Mosinger JL, Salles KS, Labruyere J, Olney JW. Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-D-aspartate neurotoxicity. J Neurosci 1989;9:2809-18
17. Zhou M, Baudry M. Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. J Neurosci 2006;26:2956-63
18. Haberny KA, Paule MG, Scallet AC, Sistare FD, Lester DS, Haniq JP, Slikker W Jr. Ontogeny of the N-methyl-D-aspartate (NMDA) receptor system and susceptibility to neurotoxicity. Toxic Sci 2002;68:9-17
19. Misha OP, Fritz KI, Delivoria-Papadopoulos M. NMDA receptor and neonatal hypoxic brain injury. Ment Retard Dev Disabil Res Rev 2001;7:249-53
20. Bickler PE, Fahlman CS, Taylor DM. Oxygen sensitivity of NMDA receptors: relationship to NR2 subunit composition and hypoxia tolerance of neonatal neurons. Neuroscience 2003;118:25-35
21. Bickler PE, Hansen BM. Hypoxia-tolerant neonatal CA1 neurons: relationship to survival to evoked glutamate release and glutamate receptor mediated calcium changes in hippocampal slices. Dev Brain Res 1998;106:57-69
22. Grojean S, Pourie G, Vert P, Daval J. Differential neuronal fates in the CA1 hippocampus after hypoxia in newborn and 7 day-old rats: effects of pretreatment with MK-801. Hippocampus 2003;13:970-7
23. Fernandez-Lopez D, Martinez-Orgado J, Casanova I, Bonet B, Leza JC, Lorenzo P, Moro MA, Lizasoain I. Immature rat brain slices exposed to oxygen-glucose deprivation as an in vitro model of neonatal hypoxic-ischemic encephalopathy. J Neurosci Methods 2005;30:145:205-12
24. Kim WT, Kuo MF, Mishra OP, Delivoria-Papadopoulos M. Distribution and expression of the subunits of N-methyl-Daspartate (NMDA) receptors; NR1, NR2A and NR2B in hypxic newborn piglet brains. Brain Res 1998;799:49-54
25. Guerguerian AM, Bambrink AM, Traystman RJ, Huganir RL, Martin LJ. Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia. Mol Brain Res 2002;104:66-80
26. Gee CE, Benquet P, Raineteau O, Rietschin L, Kirbach SW, Gerber V. NMDA receptors and the differential ischemic vulnerability of hippocampal neurons. Eur J Neurosci 2006;23:2595-603
27. Stoppini L, Buch PA, Muller D. A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 1991;37:173-82
28. Wise-Faberowski L, Zhang H, Ing R, Pearlstein RD, Warner DS. Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures. Anesth Analg 2005;101:651-7
29. Moldrich RX, Beart PM, Pascoe CJ, Cheung NS. Low-affinity kainite receptor agonists induce insult-dependent apoptosis and necrosis in cultured cortical neurons. J Neurosci Res 2000;59: 788-96
30. Hestrin S. Developmental regulation of NMDA receptor mediated at a central synapse. Nature 1992;357:686-9
31. Zhong J, Carrozza DP, Williams K, Britchett DB, Molshoff PB. Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain. J Neurochem 1995;64:531-9
32. Goebel DJ, Poosch MS. NMDA receptor subunit composition in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1, NR2A, NR2B, NR2C, NR2D and NR3A. Mol Brain Res 1999;69:164-70
33. Portera-Cailliau C, Price DL, Martin LJ. N-methyl-D-aspartate proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunitspecific antibodies. J Neurochem 1996;66:692-700
34. Barkovich AJ, Gressens P, Evrard P, Lyon G, Vrard P. Formation and maturation and developmental disorders of brain white matter and neocortex. AJNR Am J Neuroradiol 1992;13:423-61
35. Sanchez RM, Jensen FE. Maturational aspects of epilepsy mechanisms and consequences for the immature brain. Epilepsia 2001;42:577-85
36. Law AJ, Weickert CS, Webster MJ, Herman MM, Kleinman JE, Harrison PJ. Changes in NMDA receptor subunit mRNA's and cyclophilin mRNA during development of the human hippocampus. Ann N Y Acad Sci 2003;1003:426-30
37. Romijn HJ, Hoffman MA, Gramsbergen A. At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby? Early Human Dev 1991;26:61-7
38. Coultrap SJ, Nixon KM, Alvestad RM, Valenzuela CF, Browning MD. Differential expression of NMDA receptor subunits and splice variants among the CA1, CA3 and dentate gyrus of the adult rat. Brain Res Mol Brain Res 2005;135:104-11
39. Sakaguchi T, Okada M, Kuno M, Kawasaki K. Dual mode of N-methyl-D-aspartate-induced neuronal death in hippocampal slice cultures in relation to N-methyl-D-aspartate receptor properties. Neuroscience 1997;76:411-23
40. Sugimoto A, Takeda A, Kogure V, Onodera H. NMDA receptor (NMDAR1) expression in the rat hippocampus after forebrain ischemia. Neurosci Lett 1994;170:39-42
41. Laube B, Kuhse J, Betz H. Evidence for a tetrameric structure of recombinant NMDA receptors. J Neurosci 1998;18:2954-61