Confirmatory studies on the antioxidant and antidiabetic effect of quercetin in rats

Indian Journal of Clinical Biochemistry

Volumn 25, Issue 2, 2010, Pages 188-192

  Abdelmoaty, Mohamed Ahmed ^a   Ibrahim, M A ^b,c   Ahmed, N S ^a   Abdelaziz, M A ^a,c  

^a Sohag University   (Egypt)

^b SOHAG UNIVERSITY   (Egypt)

^c AL AZHAR UNIVERSITY   (Egypt)

Author keywords

Antidiabetic; Antioxidant; Flavonoid; Quercetin

Indexed keywords

ALCOHOL; ANTIOXIDANT; CATALASE; GLUCOSE; GLUTATHIONE PEROXIDASE; QUERCETIN; STREPTOZOCIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; GLYCEMIC CONTROL; HOMOGENATE; INJECTION; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PANCREAS; RAT; SINGLE DRUG DOSE; STREPTOZOCIN DIABETES;

ANIMALIA; RATTUS;

EID: 77955444921     PISSN: 09701915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12291-010-0034-x     Document Type: Article

References (25)

1. J. Baynes S. Thorpe 1996 The role of oxidative stress in diabetic complications Curr Opin Endocrinol 3 277 284 10.1097/00060793-199608000-00001
2. Y. Ihara S. Toyokuni K. Uchida H. Odaka T. Tanaka H. Ikeda 1999 Hyperglycemia causes oxidative stress in pancreatic beta cells of GK rats a model of type 2 diabetes Diabetes 48 927 932 10.2337/diabetes.48.4.927 1:CAS:528:DyaK1MXitFCqtbc%3D 10102716
3. M. Kanter I. Meral S. Dede H. Gunduz M. Cemek H. Ozbek 2003 Effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in CCl 4-treated rats J Vet Med A Physiol Pathol Clin Med 50 264 268 1:STN:280:DC%2BD3svptVSrsQ%3D%3D 14567515
4. T. Bray W. Bettger 1990 The physiological role of zinc as an antioxidant Free Radic Biol Med 8 281 291 10.1016/0891-5849(90)90076-U 1:CAS:528: DyaK3MXks1yqtbg%3D 2187766 (Pubitemid 20137051)
5. A. Rizk F. Hammouda H. Rimpler A. Kamel 1986 Iridoids and flavonoids of Teucrium polium herb Planta Med 2 87 88 10.1055/s-2007-969087 3725940
6. J. Middleton 1998 Effect of plant flavonoids on immune and inflammatory cell function Adv Exp Med Biol 439 175 182 1:CAS:528:DyaK1cXmvFKms78%3D 9781303
7. M. Laughton P. Evans M. Moroney J. Hoult B. Halliwell 1991 Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives Relationship to antioxidant activity and to iron ion-reducing ability Biochem Pharmacol 42 1673 1681 1:CAS:528:DyaK38Xjsl0%3D
8. L. Pari G. Saravanan 2002 Antidiabetic effect of cogent db, a herbal drug in alloxan-induced diabetes mellitus Comp Biochem Physiol 131 19 25 10.1016/S1096-4959(01)00474-2 1:STN:280:DC%2BD387jsFyhsg%3D%3D (Pubitemid 34056082)
9. G. du Thie A. Crozier 2000 Plant derived phenolic antioxidants Curr Opin Clin Nutr Metab 3 447 451 10.1097/00075197-200011000-00006
10. B. Fuhrman M. Aviram 2001 Flavonoids protect LDL from oxidation and attenuate atherosclerosis Curr Opin Lipidol 12 41 48 10.1097/00041433-200102000- 00008 1:CAS:528:DC%2BD3MXhtFCgsbc%3D 11176202 (Pubitemid 32121284)
11. S. Estany J. Palacio R. Barnadas M. Sabes A. Iborra P. Martínez 2007 Antioxidant activity of N-acetylcysteine, flavonoids and α-tocopherol on endometrial cells in culture J Rep Immunol 75 1 10 10.1016/j.jri.2007.01.007 1:CAS:528:DC%2BD2sXotlaju7g%3D (Pubitemid 47081185)
12. J. Un L. Mi-Kyung B. Yong A. Mi C. Myung-Sook 2006 Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice Int J Biochem Cell Biol 38 1134 1145 10.1016/j.biocel.2005. 12.002
13. M. Maria R. Kyriakos G. Dimitrios 2005 Protection against nuclear DNA damage offered by flavonoids in cells exposed to hydrogen peroxide: The role of iron chelation Free Rad Biol Med 39 1591 1600 10.1016/j.freeradbiomed.2005.08. 009 (Pubitemid 41642590)
14. R. Sara G. Seymour J. Radim B. Blanka K. Ivan K. Lyubomirova, et al. 2007 Effects of diet on biomarkers of exposure and effects, and on oxidative damage Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 620 93 102 10.1016/j.mrfmmm.2007.02.027 (Pubitemid 46776727)
15. D. Zapolska-Downar A. Kosmider M. Naruszewicz 2006 Flavonoids-rich extract from chokeberry fruits inhibits oxLDL-induced apoptosis of endothelial cells Atherosclerosis (Suppl) 7 223 224
16. C. Hii S. Howell 1984 Effects of epicatechin on rat islets of Langerhans Diabetes 33 291 296 10.2337/diabetes.33.3.291 1:CAS:528:DyaL2cXhsFSrtbs%3D 6365662
17. P. Young M. Cawthorne P. Coyle J. Holder S. Smith 1995 Report on the treatment of obese mice with BRL-49653, a new and potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell surface GLUT4 as measured by photo affinity labeling Diabetes 44 1087 1092 10.2337/diabetes.44.9.1087 1:CAS:528:DyaK2MXotVGhu70%3D 7657033
18. R. Kakkar J. Kalra S. Mantha K. Prasad 1995 Lipid peroxidation and activity of antioxidant enzymes in diabetic rats Mol Cell Biochem 151 113 119 10.1007/BF01322333 1:CAS:528:DyaK2MXptlemtbc%3D 8569756
19. H. Misra I. Fridovich 1972 The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase J Biol Chem 215 3170
20. Goldberg D, Spooner R. In methods of enzymatic analysis. (Bergmeyer HV, ed.), 3rd ed., Verlog Chemie, Deerfield Beach, FL, USA 1983; 3: 258-265.
21. R. Beers I. Sizer 1952 A spectrometric method for measuring the breakdown of hydrogen peroxide by catalase J Biol Chem 195 133 138 1:CAS:528: DyaG38Xjt12juw%3D%3D 14938361
22. A. Srinivasan V. Menon 2003 Protection of pancreatic beta cell by the potential antioxidant bis-o-hydroxycinnamoylmethane, analogue of natural curcuminoid in experimental diabetes J Pharm Pharm Sci 6 327 333 1:CAS:528:DC%2BD2cXitFSjur8%3D
23. M. Vessal M. Hemmati M. Vasie 2003 Antidiabetic effects of quercetinin streptozocin-induced diabetic rats Comp Biochem Physiol Toxicol Pharmacol 135 357 364 10.1016/S1532-0456(03)00140-6 (Pubitemid 36962949)
24. S. Wolff 1993 Diabetes mellitus and free radical. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications Br Med Bull 49 643 649
25. M. El-Missiry A. El Gindy 2000 Amelioration of alloxan induced diabetes mellitus and oxidative stress in rats by oil of Eruca sativa seeds Ann Nutr Metab 44 97 100 10.1159/000012829 1:CAS:528:DC%2BD3cXnslGlu7k%3D 11053894