New role for LEKTI in skin barrier formation: Label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI

Journal of Proteome Research

Volumn 9, Issue 8, 2010, Pages 4289-4294

  Bennett, Kate ^a   Callard, Robin ^a   Heywood, Wendy ^a   Harper, John ^a   Jayakumar, Arumugam ^a   Clayman, Gary L ^b   Di, Wei Li ^a   Mills, Kevin ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

caspase 14; cysteine protease; labelfree quantitative mass spectrometry; LEKTI; skin proteome

Indexed keywords

BLEOMYCIN HYDROLASE; CASPASE 14; CYSTEINE PROTEINASE; KALLIKREIN; LYMPHO EPITHELIAL KAZAL TYPE RELATED INHIBITOR; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ELBOW; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; NON INVASIVE PROCEDURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; PROTEOMICS; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SAMPLING; SKIN BARRIER FORMATION; SKIN BIOPSY; SKIN EXFOLIATION; SKIN FUNCTION;

CASPASE 14; CHROMATOGRAPHY, LIQUID; CYSTEINE ENDOPEPTIDASES; EPIDERMIS; HUMANS; PROTEIN STRUCTURE, TERTIARY; PROTEINASE INHIBITORY PROTEINS, SECRETORY; PROTEINS; PROTEOMICS; SERINE PROTEINASE INHIBITORS; TANDEM MASS SPECTROMETRY;

EID: 77955441579     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr1003467     Document Type: Article

References (26)

1. Magert, H. J.; Standker, L.; Kreutzmann, P.; Zucht, H. D.; Reinecke, M.; Sommerhoff, C. P.; Fritz, H.; Forssmann, W. G. LEKTI, a novel 15-domain type of human serine proteinase inhibitor J. Biol. Chem. 1999, 274 (31) 21499-21502
2. Bitoun, E.; Micheloni, A.; Lamant, L.; Bonnart, C.; Tartaglia-Polcini, A.; Cobbold, C.; Al, S. T.; Mariotti, F.; Mazereeuw-Hautier, J.; Boralevi, F.; Hohl, D.; Harper, J.; Bodemer, C.; D'Alessio, M.; Hovnanian, A. LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome Hum. Mol. Genet. 2003, 12 (19) 2417-2430
3. Hachem, J. P.; Wagberg, F.; Schmuth, M.; Crumrine, D.; Lissens, W.; Jayakumar, A.; Houben, E.; Mauro, T. M.; Leonardsson, G.; Brattsand, M.; Egelrud, T.; Roseeuw, D.; Clayman, G. L.; Feingold, K. R.; Williams, M. L.; Elias, P. M. Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome J. Invest. Dermatol. 2006, 126 (7) 1609-1621
4. Tartaglia-Polcini, A.; Bonnart, C.; Micheloni, A.; Cianfarani, F.; Andre, A.; Zambruno, G.; Hovnanian, A.; D'Alessio, M. SPINK5, the defective gene in netherton syndrome, encodes multiple LEKTI isoforms derived from alternative pre-mRNA processing J. Invest. Dermatol. 2006, 126 (2) 315-324
5. Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J. P.; Leonardsson, G.; Hovnanian, A. LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction Mol. Biol. Cell 2007, 18 (9) 3607-3619
6. Chavanas, S.; Bodemer, C.; Rochat, A.; Hamel-Teillac, D.; Ali, M.; Irvine, A. D.; Bonafe, J. L.; Wilkinson, J.; Taieb, A.; Barrandon, Y.; Harper, J. I.; de, P. Y.; Hovnanian, A. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome Nat. Genet. 2000, 25 (2) 141-142
7. Yang, T.; Liang, D.; Koch, P. J.; Hohl, D.; Kheradmand, F.; Overbeek, P. A. Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice Genes Dev. 2004, 18 (19) 2354-2358
8. Descargues, P.; Deraison, C.; Bonnart, C.; Kreft, M.; Kishibe, M.; Ishida-Yamamoto, A.; Elias, P.; Barrandon, Y.; Zambruno, G.; Sonnenberg, A.; Hovnanian, A. Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity Nat. Genet. 2005, 37 (1) 56-65
9. Hewett, D. R.; Simons, A. L.; Mangan, N. E.; Jolin, H. E.; Green, S. M.; Fallon, P. G.; McKenzie, A. N. Lethal, neonatal ichthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome Hum. Mol. Genet. 2005, 14 (2) 335-346
10. Walley, A. J.; Chavanas, S.; Moffatt, M. F.; Esnouf, R. M.; Ubhi, B.; Lawrence, R.; Wong, K.; Abecasis, G. R.; Jones, E. Y.; Harper, J. I.; Hovnanian, A.; Cookson, W. O. Gene polymorphism in Netherton and common atopic disease Nat. Genet. 2001, 29 (2) 175-178
11. Kato, A.; Fukai, K.; Oiso, N.; Hosomi, N.; Murakami, T.; Ishii, M. Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population Br. J. Dermatol. 2003, 148 (4) 665-669
12. Nishio, Y.; Noguchi, E.; Shibasaki, M.; Kamioka, M.; Ichikawa, E.; Ichikawa, K.; Umebayashi, Y.; Otsuka, F.; Arinami, T. Association between polymorphisms in the SPINK5 gene and atopic dermatitis in the Japanese Genes Immun. 2003, 4 (7) 515-517
13. Mitsudo, K.; Jayakumar, A.; Henderson, Y.; Frederick, M. J.; Kang, Y.; Wang, M.; El-Naggar, A. K.; Clayman, G. L. Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: a kinetic analysis Biochemistry 2003, 42 (13) 3874-3881
14. Egelrud, T.; Brattsand, M.; Kreutzmann, P.; Walden, M.; Vitzithum, K.; Marx, U. C.; Forssmann, W. G.; Magert, H. J. hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6 Br. J. Dermatol. 2005, 153 (6) 1200-1203
15. Schechter, N. M.; Choi, E. J.; Wang, Z. M.; Hanakawa, Y.; Stanley, J. R.; Kang, Y.; Clayman, G. L.; Jayakumar, A. Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI) Biol. Chem. 2005, 386 (11) 1173-1184
16. Borgono, C. A.; Michael, I. P.; Komatsu, N.; Jayakumar, A.; Kapadia, R.; Clayman, G. L.; Sotiropoulou, G.; Diamandis, E. P. A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation J. Biol. Chem. 2007, 282 (6) 3640-3652
17. Komatsu, N.; Takata, M.; Otsuki, N.; Ohka, R.; Amano, O.; Takehara, K.; Saijoh, K. Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides J. Invest. Dermatol. 2002, 118 (3) 436-443
18. Descargues, P.; Deraison, C.; Prost, C.; Fraitag, S.; Mazereeuw-Hautier, J.; D'Alessio, M.; Ishida-Yamamoto, A.; Bodemer, C.; Zambruno, G.; Hovnanian, A. Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome J. Invest. Dermatol. 2006, 126 (7) 1622-1632
19. Caubet, C.; Jonca, N.; Brattsand, M.; Guerrin, M.; Bernard, D.; Schmidt, R.; Egelrud, T.; Simon, M.; Serre, G. Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7 J. Invest. Dermatol. 2004, 122 (5) 1235-1244
20. Kartasova, T.; Roop, D. R.; Holbrook, K. A.; Yuspa, S. H. Mouse differentiation-specific keratins 1 and 10 require a preexisting keratin scaffold to form a filament network J. Cell Biol. 1993, 120 (5) 1251-1261
21. Fischer, H.; Stichenwirth, M.; Dockal, M.; Ghannadan, M.; Buchberger, M.; Bach, J.; Kapetanopoulos, A.; Declercq, W.; Tschachler, E.; Eckhart, L. Stratum corneum-derived caspase-14 is catalytically active FEBS Lett. 2004, 577 (3) 446-450
22. Raymond, A. A.; Mechin, M. C.; Nachat, R.; Toulza, E.; Tazi-Ahnini, R.; Serre, G.; Simon, M. Nine procaspases are expressed in normal human epidermis, but only caspase-14 is fully processed Br. J. Dermatol. 2007, 156 (3) 420-427
23. Eckhart, L.; Declercq, W.; Ban, J.; Rendl, M.; Lengauer, B.; Mayer, C.; Lippens, S.; Vandenabeele, P.; Tschachler, E. Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation J. Invest Dermatol. 2000, 115 (6) 1148-1151
24. Lippens, S.; Kockx, M.; Knaapen, M.; Mortier, L.; Polakowska, R.; Verheyen, A.; Garmyn, M.; Zwijsen, A.; Formstecher, P.; Huylebroeck, D.; Vandenabeele, P.; Declercq, W. Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing Cell Death. Differ. 2000, 7 (12) 1218-1224
25. Denecker, G.; Ovaere, P.; Vandenabeele, P.; Declercq, W. Caspase-14 reveals its secrets J. Cell Biol. 2008, 180 (3) 451-458
26. Denecker, G.; Hoste, E.; Gilbert, B.; Hochepied, T.; Ovaere, P.; Lippens, S.; Van den, B. C.; Van, D. P.; D'Herde, K.; Hachem, J. P.; Borgonie, G.; Presland, R. B.; Schoonjans, L.; Libert, C.; Vandekerckhove, J.; Gevaert, K.; Vandenabeele, P.; Declercq, W. Caspase-14 protects against epidermal UVB photodamage and water loss Nat. Cell Biol. 2007, 9 (6) 666-674