4-Anilino-6-phenyl-quinoline inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 16, 2010, Pages 4738-4740

  Olsson, Henric ^a   Sjö, Peter ^a   Ersoy, Oguz ^a   Kristoffersson, Anna ^a   Larsson, Joakim ^a   Nordén, Bo ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Kinase inhibitor; MK2; Non ATP competitive; TNF

Indexed keywords

4 ANILINO 6 PHENYLQUINOLINE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; QUINOLINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AMINOQUINOLINE DERIVATIVE; ANILINE DERIVATIVE; MAP-KINASE-ACTIVATED KINASE 2; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; QUINOLINE; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN CACO 2; COMPETITIVE INHIBITION; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; INHIBITION KINETICS; MOUSE; NONHUMAN; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINOQUINOLINES; ANILINE COMPOUNDS; CELL LINE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; LIPOPOLYSACCHARIDES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955431180     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.107     Document Type: Article

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