β-Catenin mediates the anti-adipogenic effect of baicalin

Biochemical and Biophysical Research Communications

Volumn 398, Issue 4, 2010, Pages 741-746

  Lee, Haeyong ^a   Bae, Sungmin ^a   Kim, Kijeong ^a   Kim, Wonyong ^a   Chung, Sang In ^a   Yoon, Yoosik ^a  

^a Chung Ang University College of Medicine   (South Korea)

Author keywords

Catenin; 3T3 L1; Adipogenesis; Baicalin; WNT

Indexed keywords

BAICALIN; BETA CATENIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; DISHEVELLED 2; DISHEVELLED 3 PROTEIN; DISHEVELLED PROTEIN; FATTY ACID BINDING PROTEIN 4; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WNT PROTEIN;

ADIPOGENESIS; ANIMAL CELL; ARTICLE; ATTENUATION; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; GENETIC TRANSFECTION; MEDIATOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOGENESIS; ANIMALS; BETA CATENIN; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; FLAVONOIDS; MICE; PPAR GAMMA; WNT PROTEINS;

EID: 77955430390     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.07.015     Document Type: Article

References (29)

1. Alessi M.C., Lijnen H.R., Bastelica D., Juhan-Vague I. Adipose tissue and atherothrombosis. Pathophysiol. Haemost. Thromb. 2003, 33:290-297.
2. Pi-Sunyer F.X. The obesity epidemic: pathophysiology and consequences of obesity. Obes. Res. 2002, 10(Suppl. 2):97S-104S.
3. Spiegelman B.M., Flier J.S. Obesity and the regulation of energy balance. Cell 2001, 104:531-543.
4. Green H., Meuth M. An established pre-adipose cell line and its differentiation in culture. Cell 1974, 3:127-133.
5. Cornelius P., MacDougald O.A., Lane M.D. Regulation of adipocyte development. Annu. Rev. Nutr. 1994, 14:99-129.
6. Rosen E.D., MacDougald O.A. Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell. Biol. 2006, 7:885-896.
7. Farmer S.R. Transcriptional control of adipocyte formation. Cell Metab. 2006, 4:263-273.
8. MacDougald O.A., Lane M.D. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem. 1995, 64:345-373.
9. MacDougald O.A., Mandrup S. Adipogenesis: forces that tip the scales. Trends Endocrinol. Metab. 2002, 13:5-11.
10. Bennett C.N., Ross S.E., Longo K.A., Bajnok L., Hemati N., Johnson K.W., Harrison S.D., MacDougald O.A. Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 2002, 277:30998-31004.
11. Prestwich T.C., Macdougald O.A. Wnt/beta-catenin signaling in adipogenesis and metabolism. Curr. Opin. Cell Biol. 2007, 19:612-617.
12. Cadigan K.M., Liu Y.I. Wnt signaling: complexity at the surface. J. Cell Sci. 2006, 119:395-402.
13. Fu M., Rao M., Bouras T., Wang C., Wu K., Zhang X., Li Z., Yao T.P., Pestell R.G. Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J. Biol. Chem. 2005, 280:16934-16941.
14. Shi Y., Hon M., Evans R.M. The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc. Natl. Acad. Sci. USA 2002, 99:2613-2618.
15. Liu J., Wang H., Zuo Y., Farmer S.R. Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin. Mol. Cell Biol. 2006, 26:5827-5837.
16. Freytag S.O., Geddes T.J. Reciprocal regulation of adipogenesis by Myc and C/EBP alpha. Science 1992, 256:379-382.
17. Lee H., Kang R., Hahn Y., Yang Y., Kim S.S., Cho S.H., Chung S.I., Yoon Y. Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway. Phytother. Res. 2009, 23:1615-1623.
18. Kasturi R., Joshi V.C. Hormonal regulation of stearoyl coenzyme A desaturase activity and lipogenesis during adipose conversion of 3T3-L1 cells. J. Biol. Chem. 1982, 257:12224-12230.
19. Gustafson B., Smith U. Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J. Biol. Chem. 2006, 281:9507-9516.
20. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
21. Kawai M., Mushiake S., Bessho K., Murakami M., Namba N., Kokubu C., Michigami T., Ozono K. Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha. Biochem. Biophys. Res. Commun. 2007, 363:276-282.
22. Kraus C., Liehr T., Hulsken J., Behrens J., Birchmeier W., Grzeschik K.H., Ballhausen W.G. Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development. Genomics 1994, 23:272-274.
23. Saldanha G., Ghura V., Potter L., Fletcher A. Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation. Br. J. Dermatol. 2004, 151:157-164.
24. Wang X., Goode E.L., Fredericksen Z.S., Vierkant R.A., Pankratz V.S., Liu-Mares W., Rider D.N., Vachon C.M., Cerhan J.R., Olson J.E., Couch F.J. Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. Cancer Epidemiol. Biomarkers Prev. 2008, 17:2101-2108.
25. Liu J., Farmer S.R. Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes. J. Biol. Chem. 2004, 279:45020-45027.
26. Shtutman M., Zhurinsky J., Simcha I., Albanese C., D'Amico M., Pestell R., Ben-Ze'ev A. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA 1999, 96:5522-5527.
27. Kikuchi A. Regulation of beta-catenin signaling in the Wnt pathway. Biochem. Biophys. Res. Commun. 2000, 268:243-248.
28. Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 2004, 20:781-810.
29. Huelsken J., Behrens J. The Wnt signaling pathway. J. Cell Sci. 2002, 115:3977-3978.