Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 15, 2010, Pages 5634-5646

  Skytte, Dorthe Mondrup ^a   Møller, Jesper Vuust ^b   Liu, Huizhen ^a   Nielsen, Helle Østergren ^a   Svenningsen, Louise Elsa ^a   Jensen, Christina Mernøe ^a   Olsen, Carl Erik ^a   Christensen, Søren Brøgger ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Pharmacophore; SERCA; Thapsigargin; Topography of binding cavity

Indexed keywords

ACETIC ACID DERIVATIVE; ACETIC ANHYDRIDE; HYDROXYL GROUP; OCTANOIC ACID DERIVATIVE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; THAPSIGARGIN;

ACYLATION; ARTICLE; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HYDROPHOBICITY; IC 50; PHARMACOPHORE; PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROPHOTOMETER; TOPOGRAPHY; ANIMAL; CHEMISTRY; COMPUTER SIMULATION; METABOLISM; RABBIT; SARCOPLASMIC RETICULUM;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; RABBITS; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; THAPSIGARGIN;

EID: 77955429885     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.032     Document Type: Article

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