Total synthesis of two novel subpicomolar sarco/endoplasmatic reticulum Ca2+-ATPase inhibitors designed by an analysis of the binding site of thapsigargin

Journal of Medicinal Chemistry

Volumn 48, Issue 22, 2005, Pages 7005-7011

  Søhoel, Helmer ^a   Liljefors, Tommy ^a   Ley, Steven V ^b   Oliver, Steven F ^b   Antonello, Alessandra ^b   Smith, Martin D ^b   Olsen, Carl Erik ^c   Isaacs, John T ^d   Christensen, S Brøgger ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL BUT 2 ENOIC ACID 4 BUTYRYLOXY 6 ETHOXY 3,3 DIHYDROXY 3,6,9 TRIMETHYL 2 OXO DODECAHYDRO AZULENO[4,5 B]FURAN 8 YL ESTER; 2 METHYL BUT 2 ENOIC ACID 6 ACETOXY 4 BUTYRYLOXY 3,3 DIHYDROXY 3,6,9 TRIMETHYL 2 OXO DODECAHYDRO AZULENO[4,5 B]FURAN 8 YL ESTER; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (CALCIUM) INHIBITOR; ADENOSINE TRIPHOSPHATASE INHIBITOR; CARVONE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; RABBIT; SARCOPLASMIC RETICULUM;

AZULENES; BINDING SITES; CALCIUM-TRANSPORTING ATPASES; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; LIGANDS; MODELS, MOLECULAR; SARCOPLASMIC RETICULUM; STEREOISOMERISM; THAPSIGARGIN;

EID: 27444442023     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm058036v     Document Type: Article

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