Derivatives of tetrahydroisoquinoline: Synthesis and initial evaluation of novel non-peptide antagonists of the α iIbβ 3- integrin

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4444-4446

  Krysko, Andrei A ^a   Krysko, Olga L ^a   Kabanova, Tatyana A ^a   Andronati, Sergei A ^a   Kabanov, Vladimir M ^a  

^a A V BOGATSKY PHYSICO CHEMICAL INSTITUTE   (Ukraine)

Author keywords

IIb 3; 1,2,3,4 Tetrahydroisoquinoline; Fibrinogen receptor antagonists; Platelet aggregation; RGD mimetics

Indexed keywords

4 (1,2,3,4 TETRAHYDROISOQUINOLINE 7 YL)AMINO 4 OXOBUTYRIC ACID; 5 (1,2,3,4 TETRAHYDROISOQUINOLINE 7 YL)AMINO 5 OXOPENTANOIC ACID; ALPHAIIBBETA3 INTEGRIN; ARGININE; BUTYRIC ACID DERIVATIVE; FIBRINOGEN; FLUORESCEIN ISOTHIOCYANATE; GLYCINE; INTEGRIN; PROTEIN INHIBITOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VALERIC ACID;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; THROMBOCYTE; THROMBOCYTE AGGREGATION INHIBITION;

FIBRINOGEN; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; OLIGOPEPTIDES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; TETRAHYDROISOQUINOLINES;

EID: 77955424658     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.051     Document Type: Article

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