Novel fibrinogen receptor antagonists. RGDF mimetics, derivatives of 4-(isoindoline-5-yl)amino-4-oxobutyric acid

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 22, 2004, Pages 5533-5535

  Krysko, Andrei A ^a   Chugunov, Boris M ^a   Malovichko, Olga L ^a   Andronati, Sergei A ^a   Kabanova, Tatyana A ^a   Karaseva, Tamara L ^a   Kiriyak, Anna V ^a  

^a AV Bogatsky Phys Chem Inst N   (Ukraine)

Author keywords

Fibrinogen receptor antagonists; GP IIb IIIa; Isoindoline; Platelet aggregation; RGD mimetics

Indexed keywords

4 (ISOINDOLIN 5 YL)AMINO 4 OXOBUTYRIC ACID; BUTYRIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RECEPTOR BINDING; THROMBOCYTE; THROMBOCYTE AGGREGATION;

BUTYRIC ACIDS; DRUG EVALUATION, PRECLINICAL; HUMANS; INDOLES; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, FIBRINOGEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 5144224533     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.09.002     Document Type: Article

References (10)

1. R.M. Scarborough, and D.D. Gretler J. Med. Chem. 43 2000 3454 3473
2. S.A. Andronati, T.L. Karaseva, and A.A. Krysko Curr. Med. Chem. 11 2004 1183 1211
3. J.A. Zablocki, J.G. Rico, R.B. Garland, T.E. Rogers, K. Williams, L.A. Schretzman, S.A. Rao, P.R. Bovy, F.S. Tjoeng, R.J. Lindmark, M.V. Toth, M.E. Zupec, D.E. McMackins, S.P. Adams, M. Miyano, C.S. Markos, M.N. Milton, S. Paulson, M. Herin, P. Jacqmin, N.S. Nicholson, S.G. Panzerknodle, N.F. Haas, J.D. Page, J.A. Szalony, B.B. Taite, A.K. Salyers, L.W. King, J.G. Campion, and L.P. Feigen J. Med. Chem. 38 1995 2378 2394
4. S.A. Andronati, A.A. Krysko, V.M. Kabanov, T.L. Karaseva, and T.A. Kabanova Acta Polonia Pharmaceut.-Drug Res. 57 Suppl. 2000 15 21
5. 7): δ 1.49 (s, 9H), 2.62-2.70 (m, 4H), 4.58 (dd, J = 5.9 Hz, J = 10.0 Hz, 4H), 7.26 (dd J = 4.8 Hz, J = 9.1 Hz, 1H), 7.53 (d, J = 9.1 Hz, 1H), 7.75 (d, J = 9.1 Hz, 1H), 10.12 (s, 1H). MS (FAB): 335 (M+H)
6. 6) δ 2.42-2.56 (m, 4H), 2.6-2.69 (m, 2H), 4.40-4.47 (m, 4H), 5.39 (q, J = 7.3 Hz, 1H), 7.19-7.34 (m, 6H), 7.47 (d, J = 8.1 Hz, 1H), 7.74 (s, 1H), 8.51 (d, J = 8.1 Hz, 1H), 10.05 (t, J = 5.4 Hz, 2H), 10.20 (s, 1H). MS (FAB): 382 (M+H), 404 (M+Na)
7. C.D. Eldred, B. Evans, S. Hindley, B.D. Judkins, H.A. Kelly, J. Kitchin, P. Luley, B. Porter, B.C. Ross, K.J. Smith, N.R. Taylor, and J.R. Wheatcroft J. Med. Chem. 37 1994 3882
8. G.V.R. Born Nature 194 1962 927
9. Z. Xia, T. Wong, Q. Liu, A. Kasirer-Friede, E. Brown, and M.M. Frojmnvic Br. J. Haematol. 93 1996 204 214
10. R. Hantgan Biochim. Biophys. Acta 927 1987 55 64