Active site binding modes of dimeric phloroglucinols for HIV-1 reverse transcriptase, protease and integrase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4427-4431

  Gupta, Pawan ^a   Kumar, Rajender ^a   Garg, Prabha ^a   Singh, Inder Pal ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Dimeric phloroglucinols; Docking; HIV 1 integrase; HIV 1 protease; HIV 1 reverse transcriptase

Indexed keywords

ASPARTIC ACID; HUMAN IMMUNODEFICIENCY VIRUS 1 INTEGRASE; HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE; INTEGRASE; LYSINE; PHLOROGLUCINOL; PROTEINASE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; CD4+ T LYMPHOCYTE; CELL LINE; DRUG MECHANISM; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HYDROGEN BOND; PROTEIN BINDING; PROTEIN INTERACTION;

ANTI-HIV AGENTS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE; COMPUTER SIMULATION; DIMERIZATION; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV REVERSE TRANSCRIPTASE; HUMANS; HYDROGEN BONDING; PHLOROGLUCINOL; REVERSE TRANSCRIPTASE INHIBITORS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77955423893     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.057     Document Type: Article

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