Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1524-1527

  Rankovic, Zoran ^a   Cai, Jiaqiang ^a   Kerr, Jennifer ^a   Fradera, Xavier ^a   Robinson, John ^a   Mistry, Ashvin ^a   Hamilton, Emma ^a   McGarry, George ^a   Andrews, Fiona ^a   Caulfield, Wilson ^a   Cumming, Iain ^a   Dempster, Maureen ^a   Waller, John ^a   Scullion, Paul ^a   Martin, Iain ^a   Mitchell, Ann ^a   Long, Clive ^a   Baugh, Mark ^a   Westwood, Paul ^a   Kinghorn, Emma ^a   Bruin, John ^a   Hamilton, William ^a   Uitdehaag, Joost ^a   Zeeland, Mario van ^a   Potin, Dominique ^b   Saniere, Laurent ^b   Fouquet, Andre ^b   Chevallier, François ^b   Deronzier, Hortense ^b   Dorleans, Cecile ^b   Nicolai, Eric ^b   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b CEREP   (France)

Author keywords

Cathepsin K; Cysteine protease; Osteoporosis

Indexed keywords

CATHEPSIN B; CATHEPSIN K INHIBITOR; CATHEPSIN L; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; EMBRYO; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; CATHEPSIN K; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 76649129834     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.100     Document Type: Article

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