Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4- dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4526-4530

  Li, Qianbin ^a   Wu, Jingde ^a   Zheng, Hui ^b   Liu, Kai ^a   Guo, Tai L ^a   Liu, Yuying ^b   Eblen, Scott T ^b   Grant, Steven ^a   Zhang, Shijun ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Dual pathway inhibitor; PI3K Akt; Raf MEK ERK; Thiazolidine 2,4 dione

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 (2 AMINOETHYL) 5 (3 PHENYL PROPYLIDENE) THIAZOLIDINE 2,4 DIONE; ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAF PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN U937; COMPETITIVE INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; SIGNAL TRANSDUCTION; THIAZOLIDINES;

EID: 77955413802     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.030     Document Type: Article

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