1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 16, 2010, Pages 4816-4818

  Kern, Jeffrey C ^a   Terefenko, Eugene ^a   Trybulski, Eugene ^a   Berrodin, Thomas J ^a   Cohen, Jeffrey ^a   Winneker, Richard C ^a   Yudt, Matthew R ^a   Zhang, Zhiming ^a   Zhu, Yuan ^a   Zhang, Puwen ^a  

^a PFIZER INC   (United States)

Author keywords

1 Methyl 1H pyrrole 2 carbonitrile; Antagonist; Modulator; Nuclear hormone; Progesterone; Tetrahydronaphthalene

Indexed keywords

1 METHYL 1H PYRROLE 2 CARBONITRILE; ALKALINE PHOSPHATASE; MIFEPRISTONE; NAPHTHALENE DERIVATIVE; PROGESTERONE; PROGESTERONE RECEPTOR; RECEPTOR BLOCKING AGENT; TETRALIN; UNCLASSIFIED DRUG; PYRROLE DERIVATIVE; TETRALIN DERIVATIVE;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ASSAY; IC 50; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ALKALINE PHOSPHATASE; CELL LINE, TUMOR; HUMANS; PYRROLES; RECEPTORS, PROGESTERONE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 77955413500     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.109     Document Type: Article

References (17)

1. A.A. Yuzpe J. Reprod. Med. 47 2002 967
2. A. Brown, L. Cheng, S. Lin, and D.T. Baird J. Clin. Endocrinol. Metab. 87 2002 63
3. L.M. Kettel, A.A. Murphy, A.J. Morales, A. Ulmann, E.E. Baulieu, and S.S. Yen Fertil. Steril. 65 1996 23
4. A.A. Murphy, L.M. Kettel, A.J. Morales, V.J. Roberts, and S.S. Yen J. Clin. Endocrinol. Metab. 76 1993 513
5. R.N. Brogden, K.L. Goa, and D. Faulds Drugs 45 1993 384
6. D.W. Combs, K. Reese, L.A.M. Cornelius, J.W. Gunnet, E.V. Cryan, K.S. Granger, J.J. Jordan, and K.T. Demarest J. Med. Chem. 38 1995 4880
7. K. Kurihara, K. Tanabe, Y. Yamamoto, R. Shinei, K. Ajito, and T. Okonogi Bioorg. Med. Chem. Lett. 9 1999 1837
8. L. Zhi, C.M. Tegley, B. Pio, J.P. Edwards, M. Motamedi, T.K. Jones, K.B. Marschke, D.E. Mais, B. Risek, and W.T. Schrader J. Med. Chem. 46 2003 4104
9. N. Jain, G. Allan, O. Linton, P. Tannenbaum, X. Chen, J. Xu, P. Zhu, J. Gunnet, K. Demarest, S. Lundeen, W. Murray, and Z. Sui Bioorg. Med. Chem. Lett. 19 2009 3977
10. Y. Wang, C. Duraiswami, K.P. Madauss, T.B. Tran, S.P. Williams, S. Deng, T.L. Graybill, M. Hammond, D.G. Jones, E.T. Grygielko, J.D. Bray, and S.K. Thompson Bioorg. Med. Chem. Lett. 19 2009 4916
11. M.A. Collins, V. Hudak, R. Bender, A. Fensome, P. Zhang, L. Miller, R.C. Winneker, Z. Zhang, Y. Zhu, J. Cohen, R.J. Unwalla, and J. Wrobel Bioorg. Med. Chem. Lett. 14 2004 2185
12. A. Fensome, R. Bender, R. Chopra, J. Cohen, M.A. Collins, V. Hudak, K. Malakian, S. Lockhead, A. Olland, K. Svenson, E.A. Terefenko, R.J. Unwalla, J.M. Wilhelm, S. Wolfrom, Y. Zhu, Z. Zhang, P. Zhang, R.C. Winneker, and J. Wrobel J. Med. Chem. 48 2005 5092
13. P. Zhang, E.A. Terefenko, A. Fensome, J. Wrobel, R. Winneker, S. Lundeen, K.B. Marschke, and Z. Zhang J. Med. Chem. 45 2002 4379
14. Zhang, P.; Kern, J. C.; Terefenko, E. A.; Trybulski, E. J. US Patent 20070066628A1; US Patent 7,319,152.
15. J.C. Kern, E. Terefenko, E. Trybulski, T.J. Berrodin, J. Cohen, R.C. Winneker, M.R. Yudt, Z. Zhang, Y. Zhu, and P. Zhang Bioorg. Med. Chem. Lett. 19 2009 6666
16. +), 267.1494.
17. I. Sadowski, B. Bell, P. Broad, and M. Hollis Gene 118 1992 137