Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D2 synthases

Journal of Medicinal Chemistry

Volumn 53, Issue 15, 2010, Pages 5536-5548

  Christ, Angelika N ^a   Labzin, Larisa ^a   Bourne, Gregory T ^a   Fukunishi, Hirotada ^b   Weber, Jane E ^a   Sweet, Matthew J ^a   Smythe, Mark L ^a   Flanagan, Jack U ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b SHISEIDO RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYL 5 (1H PYRAZOL 3 YL)THIAZOLE; 6 OXOPROSTAGLANDIN F1 ALPHA; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; N (1 AMINO 1 OXO 3 PHENYLPROPAN 2 YL) 6 (THIOPHEN 2 YL)NICOTINAMIDE; N BENZHYDRYL 5 (3 HYDROXYPHENYL)THIOPHENE 2 CARBOXAMIDE; PROSTAGLANDIN D SYNTHASE; PROSTAGLANDIN D2 SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; THROMBOXANE B2; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; MACROPHAGE; MEGAKARYOCYTE; MOUSE; NONHUMAN; PROSTAGLANDIN RELEASE;

ANIMALS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; HEMATOPOIESIS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIGANDS; LIPOCALINS; MACROPHAGES; MEGAKARYOCYTES; MICE; MODELS, MOLECULAR; NIACINAMIDE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TOLL-LIKE RECEPTORS;

EID: 77955403137     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100194a     Document Type: Article

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