Amyloid β precursor protein regulates male sexual behavior

Journal of Neuroscience

Volumn 30, Issue 30, 2010, Pages 9967-9972

  Park, Jin Ho ^a   Bonthius, Paul J ^a   Tsai, Houng Wei ^a,b   Bekiranov, Stefan ^a   Rissman, Emilie F ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; HORMONE RECEPTOR; SEX HORMONE;

ANIMAL EXPERIMENT; ARTICLE; C57BL 6 MOUSE; CASTRATION; CONTROLLED STUDY; DBA 2 MOUSE; GENE OVEREXPRESSION; HYPOTHALAMUS; MALE; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SEXUAL BEHAVIOR; TRANSGENIC ANIMAL;

AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORCHIECTOMY; PREOPTIC AREA; RNA, MESSENGER; SEPTAL NUCLEI; SEXUAL BEHAVIOR, ANIMAL; SIGNAL TRANSDUCTION;

EID: 77955400675     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1988-10.2010     Document Type: Article

References (45)

1. Andrä K, Abramowski D, Duke M, Probst A, Wiederhold KH, Bürki K, Goedert M, Sommer B, Staufenbiel M (1996) Expression of APP in transgenic mice: a comparison of neuron-specific promoters. Neurobiol Aging 17:183-190. (Pubitemid 26167631)
2. Bagatell CJ, Heiman JR, Rivier JE, Bremner WJ (1994) Effects of endogenous testosterone and estradiol on sexual behavior in normal young men. J Clin Endocrinol Metab 78:711-716.
3. Beni SM, Tsenter J, Alexandrovich AG, Galron-Krool N, Barzilai A, Kohen R, Grigoriadis N, Simeonidou C, Shohami E (2006) CuZn-SOD deficiency, rather than overexpression, is associated with enhanced recovery and attenuated activation of NF-kappaB after brain trauma in mice. J Cereb Blood Flow Metab 26:478-490.
4. Benjamini Y, HochbergY (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc 57:289-300.
5. Benjamini Y, Yekutieli D (2001) The control of false discovery rate in multiple testing under dependency. Ann Stat 29:1165-1188.
6. Bolstad BM, Irizarry RA, Astrand M, Speed TP (2003) A comparison of normalization methods for high density oligonucleotide array data based on bias and variance. Bioinformatics 19:185-193. (Pubitemid 36181903)
7. Bronson FH (1989) Mammalian reproductive biology. Chicago: University of Chicago.
8. Clemens LG, Wee BE, Weaver DR, Roy EJ, Goldman BD, Rakerd B (1988) Retention of masculine sexual behavior following castration in male B6D2F1 mice. Physiol Behav 42:69-76.
9. Coquelin A (1991) Persistent sexual behavior in castrated, recombinant inbred mice. Biol Reprod 45:680-684.
10. Franklin KBJ, PaxinosG (1997) The mouse brain in stereotaxic coordinates. New York: Academic.
11. Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W, eds (2005) Bioinformatics and computational biology solutions using R and bioconductor. New York: Springer.
12. Greenfield JP, Leung LW, Cai D, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu H (2002) Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J Biol Chem 277:12128-12136.
13. Higgins LS, Rodems JM, Catalano R, Quon D, Cordell B (1995) Early Alzheimerdisease-like histopathology increases in frequency with age in mice transgenic for beta-APP751. Proc Natl Acad Sci U S A 92:4402-4406.
14. Hirokawa N (1994) Microtubule organization and dynamics dependent on microtubule-associated proteins. Curr Opin Cell Biol 6:74-81.
15. Kammesheidt A, Boyce FM, Spanoyannis AF, Cummings BJ, Ortegón M, Cotman C, Vaught JL, Neve RL (1992) Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci U S A 89:10857-10861.
16. Khatri P, Drǎghici S (2005) Ontological analysis of gene expression data: current tools, limitations, and open problems. Bioinformatics 21:3587-3595.
17. Kim D, Tsai LH (2009) Bridging physiology and pathology in AD. Cell 137:997-1000.
18. Kwon CH, Zhou J, Li Y, Kim KW, Hensley LL, Baker SJ, Parada LF (2006a) Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations. Genesis 44:130-135.
19. Kwon CH, Luikart BW, Powell CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF (2006b) Pten regulates neuronal arborization and social interaction in mice. Neuron 50:377-388.
20. Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, KearnsWG,Pearson PL, Price DL, Gearhart JD (1993) Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nat Genet 5:22-30.
21. Lunenfeld B (2006) Endocrinology of the aging male. Minerva Ginecol 58:153-170.
22. McGill TE, Manning A (1976) Genotype and retention of the ejaculatory reflex in castrated male mice. Anim Behav 24:507-518.
23. Micheal RP, Wilson M (1974) Effects of castration and hormone replacement in fully adult male rhesus monkeys (Macaca mulatta). Endocrinology 95:150-159.
24. Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR (1994) Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Res 666:151-167.
25. Park JH, Bonthuis P, Ding A, Rais S, Rissman EF (2009) Androgen- and estrogen-independent regulation of copulatory behavior following castration in male B6D2F1 mice. Horm Behav 56:254-263.
26. Phoenix CH, Slob AK, Goy RW (1973) Effects of castration and replacement therapy on sexual behavior of adult male rhesuses. J Comp Physiol Psychol 84:472-481.
27. Pike CJ, Carroll JC, Rosario ER, Barron AM (2009) Protective actions of sex steroid hormones in Alzheimer's disease. Front Neuroendocrinol 30:239-258.
28. Quon D, Wang Y, Catalano R, Scardina JM, Murakami K, Cordell B (1991) Formation of beta-amyloid protein deposits in brains of transgenic mice. Nature 352:239-241. (Pubitemid 21912324)
29. Rademakers R, Cruts M, van BroeckhovenC (2004) The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Hum Mutat 24:277-295.
30. Selkoe DJ (1999) Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399:A23-A31.
31. Sinchak K, Roselli CE, Clemens LG (1996) Levels of serum steroids, aromatase activity, and estrogen receptors in preoptic area, hypothalamus, and amygdala of B6D2F1 male house mice that differ in the display of copulatory behavior after castration. Behav Neurosci 110:593-602.
32. Sinha S, Lieberburg I (1999) Cellular mechanisms of beta-amyloid production and secretion. Proc Natl Acad Sci U S A 96:11049-11053. (Pubitemid 29487325)
33. Smyth GK (2004) Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3:3.
34. Stiles B, Groszer M, Wang S, Jiao J, Wu H (2004) PTENless means more. Dev Biol 273:175-184.
35. Van Dam D, D'Hooge R, Staufenbiel M, Van Ginneken C, Van Meir F, De Deyn PP (2003) Age-dependent cognitive decline in the APP23 model precedes amyloid deposition. Eur J Neurosci 17:388-396.
36. Vloeberghs E, Van Dam D, Engelborghs S, Nagels G, Staufenbiel M, De Deyn PP (2004) Altered circadian locomotor activity in APP23 mice: a model for BPSD disturbances. Eur J Neurosci 20:2757-2766.
37. Vloeberghs E, Van Dam D, Coen K, Staufenbiel M, De Deyn PP (2006) Aggressive male APP23 mice modeling behavioral alterations in dementia. Behav Neurosci 120:1380-1383.
38. Vloeberghs E, Van Dam D, Franck F, Staufenbiel M, De Deyn PP (2007) Mood and male sexual behaviour in the APP23 model of Alzheimer's disease. Behav Brain Res 180:146-151. (Pubitemid 46729569)
39. Wallace M, Safer M (2009) Hypersexuality among cognitively impaired older adults. Geriatr Nurs 30:230-237.
40. Wersinger SR, Sannen K, Villalba C, Lubahn DB, Rissman EF, De Vries GJ (1997) Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene. Horm Behav 32:176-183.
41. Wilt TJ, MacDonald R, Rutks I, Shamliyan TA, Taylor BC, Kane RL (2008) Systematic review: comparative effectiveness and harms of treatments for clinically localized prostate cancer. Ann Intern Med 148:435-448.
42. Wu Z, Irizarry RA, Gentleman R, Martinez-Murillo F, Spencer F (2004) A model based background adjustment for oligonucleotide expression arrays. J Am Stat Assoc 99:909-917. (Pubitemid 39665934)
43. Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, Sisodia SS, Wang R, Greengard P, Gandy S (1998) Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med 4:447-451.
44. Yao M, Nguyen TV, Rosario ER, Ramsden M, Pike CJ (2008) Androgens regulate neprilysin expression: role in reducing beta-amyloid levels. J Neurochem 105:2477-2488.
45. Zeiss AM, Davies HD, Wood M, Tinklenberg JR (1990) The incidence and correlates of erectile problems in patients with Alzheimer's disease. Arch Sex Behav 19:325-331.