Long-term adaptation to high doses of morphine causes desensitization of μ-or- and δ-or-stimulated g-protein response in forebrain cortex but does not decrease the amount of g-protein alpha subunits

Case Reports and Clinical Practice Review

Volumn 16, Issue 8, 2010, Pages

  Bourova, Lenka ^a   Vosahlikova, Miroslava ^a   Kagan, Dmytro ^a,b   Dlouha, Katerina ^a   Novotny, Jiri ^a,b   Svoboda, Petr ^a,b  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Forebrain cortex; G protein; Morphine; Opioid receptors; Plasma membranes

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; DELTA OPIATE RECEPTOR; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATASE; MORPHINE; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; PHOSPHATE BUFFERED SALINE; REGULATOR PROTEIN; GUANOSINE DIPHOSPHATE;

ADAPTIVE BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; DRUG DEPENDENCE; FOREBRAIN; FRONTAL CORTEX; MALE; NONHUMAN; PROTEIN FUNCTION; PROTEIN ISOLATION; RAT; RECEPTOR DOWN REGULATION; ADAPTATION; ANIMAL; ANIMAL BEHAVIOR; BRAIN CORTEX; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; DRUG TOLERANCE; ENZYMOLOGY; METABOLISM; PATHOPHYSIOLOGY; TIME; WISTAR RAT; WITHDRAWAL SYNDROME; ANIMAL CELL; BINDING ASSAY; CELL ISOLATION; DRUG SENSITIVITY; DRUG SPECIFICITY; ENZYME ACTIVITY; ENZYME BINDING; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BACLOFEN; BEHAVIOR, ANIMAL; CELL MEMBRANE; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GTP-BINDING PROTEIN ALPHA SUBUNITS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; MALE; MORPHINE; RATS; RATS, WISTAR; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SUBSTANCE WITHDRAWAL SYNDROME; TIME FACTORS;

EID: 77955398602     PISSN: 15076164     EISSN: 16433742     Source Type: Journal    
DOI: None     Document Type: Article

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