Mouse mutagenesis with the chemical supermutagen ENU

Methods in Enzymology

Volumn 477, Issue C, 2010, Pages 297-312

  Probst, Frank J ^a   Justice, Monica J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MUTAGEN; ETHYLNITROSOUREA;

ARTICLE; AUTOSOME; BREEDING; CHEMICAL STRUCTURE; CHROMOSOME; DNA SEQUENCE; GAMETE; GENE INACTIVATION; GENE ISOLATION; GENE MUTATION; GERM LINE; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROGENY; SCREENING; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALIA; MUS;

EID: 77955385224     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(10)77015-4     Document Type: Chapter

References (42)

1. Blewitt M.E., Vickaryous N.K., Hemley S.J., Ashe A., Bruxner T.J., Preis J.I., Arkell R., Whitelaw E. An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc. Natl. Acad. Sci. USA 2005, 102:7629-7634.
2. Boles M.K., Wilkinson B.M., Maxwell A., Lai L., Mills A.A., Nishijima I., Salinger A.P., Moskowitz I., Hirschi K.K., Liu B., Bradley A., Justice M.J. A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines. BMC Genet. 2009, 10:12.
3. Boles M.K., Wilkinson B.M., Wilming L.G., Liu B., Probst F.J., Harrow J., Grafham D., Hentges K.E., Woodward L.P., Maxwell A., Mitchell K., Risley M.D., et al. Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genet. 2009, 5:e1000759.
4. Brown S.D., Wurst W., Kuhn R., Hancock J.M. The functional annotation of mammalian genomes: The challenge of phenotyping. Annu. Rev. Genet. 2009, 43:305-333.
5. Buac K., Watkins-Chow D.E., Loftus S.K., Larson D.M., Incao A., Gibney G., Pavan W.J. A Sox10 expression screen identifies an amino acid essential for Erbb3 function. PLoS Genet. 2008, 4:e1000177.
6. Carpinelli M.R., Hilton D.J., Metcalf D., Antonchuk J.L., Hyland C.D., Mifsud S.L., Di Rago L., Hilton A.A., Willson T.A., Roberts A.W., Ramsay R.G., Nicola N.A., et al. Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc. Natl. Acad. Sci. USA 2004, 101:6553-6558.
7. Cordes S.P., Barsh G.S. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell 1994, 79:1025-1034.
8. Davis A.P., Woychik R.P., Justice M.J. Effective chemical mutagenesis in FVB/N mice requires low doses of ethylnitrosourea. Mamm. Genome 1999, 10:308-310.
9. Ebersole T.A., Chen Q., Justice M.J., Artzt K. The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins. Nat. Genet. 1996, 12:260-265.
10. Ehling U.H. Specific-locus mutations in mice. Chemical Mutagens: Principles and Methods for Their Detection, Vol. 5 1978, 233-256. Plenum Press, New York. A. Hollaender, F.J. de Serres (Eds.).
11. Ehling U.H., Neuhauser A. Procarbazine-induced specific-locus mutations in male mice. Mutat. Res. 1979, 59:245-256.
12. Ehling U.H., Neuhauser-Klaus A. Induction of specific-locus mutations in male mice by ethyl methanesulfonate (EMS). Mutat. Res. 1989, 227:91-95.
13. Fernandez L., Marchuk D.A., Moran J.L., Beier D.R., Rockman H.A. An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15. Mamm. Genome 2009, 20:296-304.
14. Garcia-Garcia M.J., Eggenschwiler J.T., Caspary T., Alcorn H.L., Wyler M.R., Huangfu D., Rakeman A.S., Lee J.D., Feinberg E.H., Timmer J.R., Anderson K.V. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. USA 2005, 102:5913-5919.
15. Hentges K.E., Justice M.J. Checks and balancers: Balancer chromosomes to facilitate genome annotation. Trends Genet. 2004, 20:252-259.
16. Hentges K.E., Nakamura H., Furuta Y., Yu Y., Thompson D.M., O'Brien W., Bradley A., Justice M.J. Novel lethal mouse mutants produced in balancer chromosome screens. Gene Expr. Patterns 2006, 6:653-665.
17. Herron B.J., Lu W., Rao C., Liu S., Peters H., Bronson R.T., Justice M.J., McDonald J.D., Beier D.R. Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat. Genet. 2002, 30:185-189.
18. Hitotsumachi S., Carpenter D.A., Russell W.L. Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proc. Natl. Acad. Sci. USA 1985, 82:6619-6621.
19. Hrabe de Angelis M.H., Flaswinkel H., Fuchs H., Rathkolb B., Soewarto D., Marschall S., Heffner S., Pargent W., Wuensch K., Jung M., Reis A., Richter T., et al. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat. Genet. 2000, 25:444-447.
20. Justice M.J. Capitalizing on large-scale mouse mutagenesis screens. Nat. Rev. Genet. 2000, 1:109-115.
21. Justice M.J. Removing the cloak of invisibility: Phenotyping the mouse. Dis. Models Mech. 2008, 1:109-112.
22. Justice M.J., Noveroske J.K., Weber J.S., Zheng B., Bradley A. Mouse ENU mutagenesis. Hum. Mol. Genet. 1999, 8:1955-1963.
23. Kasarskis A., Manova K., Anderson K.V. A phenotype-based screen for embryonic lethal mutations in the mouse. Proc. Natl. Acad. Sci. USA 1998, 95:7485-7490.
24. Kauppi M., Murphy J.M., de Graaf C.A., Hyland C.D., Greig K.T., Metcalf D., Hilton A.A., Nicola N.A., Kile B.T., Hilton D.J., Alexander W.S. Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood 2008, 112:3148-3153.
25. Kile B.T., Hentges K.E., Clark A.T., Nakamura H., Salinger A.P., Liu B., Box N., Stockton D.W., Johnson R.L., Behringer R.R., Bradley A., Justice M.J. Functional genetic analysis of mouse chromosome 11. Nature 2003, 425:81-86.
26. Kohler S.W., Provost G.S., Fieck A., Kretz P.L., Bullock W.O., Sorge J.A., Putman D.L., Short J.M. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc. Natl. Acad. Sci. USA 1991, 88:7958-7962.
27. Matera I., Watkins-Chow D.E., Loftus S.K., Hou L., Incao A., Silver D.L., Rivas C., Elliott E.C., Baxter L.L., Pavan W.J. A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum. Mol. Genet. 2008, 17:2118-2131.
28. Mohan S., Baylink D.J., Srivastava A.K. A chemical mutagenesis screen to identify modifier genes that interact with growth hormone and TGF-beta signaling pathways. Bone 2008, 42:388-395.
29. Nolan P.M., Peters J., Strivens M., Rogers D., Hagan J., Spurr N., Gray I.C., Vizor L., Brooker D., Whitehill E., Washbourne R., Hough T., et al. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat. Genet. 2000, 25:440-443.
30. Quwailid M.M., Hugill A., Dear N., Vizor L., Wells S., Horner E., Fuller S., Weedon J., McMath H., Woodman P., Edwards D., Campbell D., et al. A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm. Genome 2004, 15:585-591.
31. Rubio-Aliaga I., Soewarto D., Wagner S., Klaften M., Fuchs H., Kalaydjiev S., Busch D.H., Klempt M., Rathkolb B., Wolf E., Abe K., Zeiser S., et al. A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. Genetics 2007, 175:1451-1463.
32. Russell W.L. X-ray-induced mutations in mice. Cold Spring Harb. Symp. Quant. Biol. 1951, 16:327-336.
33. Russell W.L., Kelley E.M. Ineffectiveness of diethylnitrosamine in the induction of specific-locus mutations in mice. Genetics 1979, 91(Suppl.):s109-s110.
34. Russell W.L., Russell L.B., Kelly E.M. Radiation dose rate and mutation frequency. Science 1958, 128:1546-1550.
35. Russell W.L., Kelly E.M., Hunsicker P.R., Bangham J.W., Maddux S.C., Phipps E.L. Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Proc. Natl. Acad. Sci. USA 1979, 76:5818-5819.
36. Russell W.L., Hunsicker P.R., Carpenter D.A., Cornett C.V., Guinn G.M. Effect of dose fractionation on the ethylnitrosourea induction of specific-locus mutations in mouse spermatogonia. Proc. Natl. Acad. Sci. USA 1982, 79:3592-3593.
37. Russell W.L., Hunsicker P.R., Raymer G.D., Steele M.H., Stelzner K.F., Thompson H.M. Dose-response curve for ethylnitrosourea-induced specific-locus mutations in mouse spermatogonia. Proc. Natl. Acad. Sci. USA 1982, 79:3589-3591.
38. Shumacher A., Faust C., Magnuson T. Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature 1996, 383:250-253.
39. Singer B. All oxygens in nucleic acids react with carcinogenic ethylating agents. Nature 1976, 264:333-339.
40. Sun L., Singer B. The specificity of different classes of ethylating agents toward various sites of HeLa cell DNA in vitro and in vivo. Biochemistry 1975, 14:1795-1802.
41. Weber J.S., Salinger A., Justice M.J. Optimal N-ethyl-N-nitrosourea (ENU) doses for inbred mouse strains. Genesis 2000, 26:230-233.
42. Zohn I.E., Anderson K.V., Niswander L. Using genomewide mutagenesis screens to identify the genes required for neural tube closure in the mouse. Birth Defects Res. A Clin. Mol. Teratol. 2005, 73:583-590.