Mutational analysis of VIM-2 reveals an essential determinant for metallo-β-lactamase stability and folding

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 8, 2010, Pages 3197-3204

  Borgianni, Luisa ^a   Vandenameele, Julie ^b   Matagne, André ^b   Bini, Luca ^a   Bonomo, Robert A ^c   Frère, Jean Marie ^b   Rossolini, Gian Maria ^a   Docquier, Jean Denis ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; AZTREONAM; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; CEFALOTIN; CEFEPIME; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; ERTAPENEM; IMIPENEM; MEROPENEM; METALLO BETA LACTAMASE; NITROCEFIN; PIPERACILLIN; PROTEIN; PROTEIN VIM 2; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; MINIMUM INHIBITORY CONCENTRATION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY;

AMPICILLIN; AMPICILLIN RESISTANCE; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; DNA MUTATIONAL ANALYSIS; ENZYME STABILITY; ESCHERICHIA COLI; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955383826     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01336-09     Document Type: Article

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