Single-cell analysis of T-cell receptor repertoire of HTLV-1 tax-specific cytotoxic T cells in allogeneic transplant recipients with adult T-cell leukemia/lymphoma

Cancer Research

Volumn 70, Issue 15, 2010, Pages 6181-6192

  Tanaka, Yukie ^a   Nakasone, Hideki ^a   Yamazaki, Rie ^a   Sato, Ken ^a   Sato, Miki ^a   Terasako, Kiriko ^a   Kimura, Shun Ichi ^a   Okuda, Shinya ^a   Kako, Shinichi ^a   Oshima, Kumi ^a   Tanihara, Aki ^a   Nishida, Junji ^a   Yoshikawa, Toshiaki ^b   Nakatsura, Tetsuya ^b   Sugiyama, Haruo ^c   Kanda, Yoshinobu ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A ANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ALLOTRANSPLANTATION; ARTICLE; BLOOD; BONE MARROW; CYTOTOXIC T LYMPHOCYTE; CYTOTOXIC T LYMPHOCYTE TAX301-309; GRAFT RECIPIENT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; PRIORITY JOURNAL; PROTEIN MOTIF; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T CELL LEUKEMIA; T CELL LYMPHOMA;

AMINO ACID MOTIFS; GENE PRODUCTS, TAX; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA-A ANTIGENS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LEUKEMIA-LYMPHOMA, ADULT T-CELL; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES, CYTOTOXIC;

EID: 77955361749     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-0678     Document Type: Article

References (47)

1. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 1977;50:481-92. (Pubitemid 8180432)
2. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A 1980;77:7415-9.
3. Hinuma Y, Nagata K, Hanaoka M, et al. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A 1981;78:6476-80. (Pubitemid 12179735)
4. Yoshida M, Miyoshi I, Hinuma Y. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A 1982;79:2031-5.
5. Kannagi M, Shida H, Igarashi H, et al. Target epitope in the Tax protein of human T-cell leukemia virus type I recognized by class I major histocompatibility complex-restricted cytotoxic T cells. J Virol 1992;66:2928-33.
6. Pique C, Connan F, Levilain JP, Choppin J, Dokhelar MC. Among all human T-cell leukemia virus type 1 proteins, tax, polymerase, and envelope proteins are predicted as preferential targets for the HLA-A2-restricted cytotoxic T-cell response. J Virol 1996;70:4919-26. (Pubitemid 26240658)
7. Utsunomiya A, Miyazaki Y, Takatsuka Y, et al. Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2001;27:15-20.
8. Kami M, Hamaki T, Miyakoshi S, et al. Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma. Br J Haematol 2003;120:304-9.
9. Okamura J, Utsunomiya A, Tanosaki R, et al. Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma. Blood 2005;105:4143-5.
10. Shiratori S, Yasumoto A, Tanaka J, et al. A retrospective analysis of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia/lymphoma (ATL): clinical impact of graft-versus-leukemia/lymphoma effect. Biol Blood Marrow Transplant 2008;14:817-23.
11. Kato K, Kanda Y, Eto T, et al. Allogeneic bone marrow transplantation from unrelated human T-cell leukemia virus-I-negative donors for adult T-cell leukemia/lymphoma: retrospective analysis of data from the Japan Marrow Donor Program. Biol Blood Marrow Transplant 2007;13:90-9.
12. Harashima N, Kurihara K, Utsunomiya A, et al. Graft-versus-Tax response in adult T-cell leukemia patients after hematopoietic stem cell transplantation. Cancer Res 2004;64:391-9. (Pubitemid 38114123)
13. Yashiki S, Fujiyoshi T, Arima N, et al. HLA-A*26, HLA-B*4002, HLA-B* 4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes. AIDS Res Hum Retroviruses 2001;17:1047-61.
14. Harashima N, Tanosaki R, Shimizu Y, et al. Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation. J Virol 2005;79:10088-92.
15. Hara H, Morita M, Iwaki T, et al. Detection of human T lymphotrophic virus type I (HTLV-I) proviral DNA and analysis of T cell receptor Vβ CDR3 sequences in spinal cord lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis. J Exp Med 1994;180:831-9. (Pubitemid 24979059)
16. Elovaara I, Utz U, Smith S, Jacobson S. Limited T cell receptor usage by HTLV-I tax-specific, HLA class I restricted cytotoxic T lymphocytes from patients with HTLV-I associated neurological disease. J Neuroimmunol 1995;63:47-53.
17. Utz U, Banks D, Jacobson S, Biddison WE. Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion. J Virol 1996;70:843-51. (Pubitemid 26029000)
18. Bieganowska K, Hollsberg P, Buckle GJ, et al. Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy. J Immunol 1999;162:1765-71.
19. Ureta-Vidal A, Pique C, Garcia Z, et al. Human T cell leukemia virus type I (HTLV-I) infection induces greater expansions of CD8 T lymphocytes in persons with HTLV-I-associated myelopathy/tropical spastic paraparesis than in asymptomatic carriers. J Infect Dis 2001;183:857-64.
20. Bourcier KD, Lim DG, Ding YH, Smith KJ, Wucherpfennig K, Hafler DA. Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of Tcell fine specificity and major histocompatibility complex/peptide/TCR crystal structure. J Virol 2001;75:9836-43. (Pubitemid 32900119)
21. Saito M, Taylor GP, Saito A, et al. In vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes. J Virol 2001;75:1065-71.
22. Saito M, Higuchi I, Saito A, et al. Molecular analysis of T cell clono-types in muscle-infiltrating lymphocytes from patients with human T lymphotropic virus type 1 polymyositis. J Infect Dis 2002;186:1231-41.
23. Kato T, Asahara H, Kurokawa MS, et al. HTLV-I env protein acts as a major antigen in patients with HTLV-I-associated arthropathy. Clin Rheumatol 2004;23:400-9.
24. Eiraku N, Hingorani R, Ijichi S, et al. Clonal expansion within CD4+ and CD8+ T cell subsets in human T lymphotropic virus type I-infected individuals. J Immunol 1998;161:6674-80. (Pubitemid 28562209)
25. Wlodarski MW, Gondek LP, Nearman ZP, et al. Molecular strategies for detection and quantitation of clonal cytotoxic T-cell responses in aplastic anemia and myelodysplastic syndrome. Blood 2006;108:2632-41.
26. Kalams SA, Johnson RP, Trocha AK, et al. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J Exp Med 1994;179:1261-71.
27. Ding YH, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 1998;8:403-11.
28. Hausmann S, Biddison WE, Smith KJ, et al. Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures. J Immunol 1999;162:5389-97. (Pubitemid 29307147)
29. Baker BM, Turner RV, Gagnon SJ, Wiley DC, Biddison WE. Identification of a crucial energetic footprint on the α1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors. J Exp Med 2001;193:551-62.
30. Tanaka-Harada Y, Kawakami M, Oka Y, et al. Biased usage of BV gene families of T cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies. Cancer Sci 2010;101:594-600.
31. Koya Y, Ohashi T, Kato H, et al. Establishment of a seronegative human T-cell leukemia virus type 1 (HTLV-1) carrier state in rats inoculated with a syngeneic HTLV-1-immortalized T-cell line preferentially expressing Tax. J Virol 1999;73:6436-43.
32. Aubry JP, Blaecke A, Lecoanet-Henchoz S, et al. Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity. Cytometry 1999;37:197-204.
33. Baba M, Okamoto M, Hamasaki T, et al. Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells. J Virol 2008;82:3843-52. (Pubitemid 351521221)
34. Yoshie O, Fujisawa R, Nakayama T, et al. Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. Blood 2002;99:1505-11.
35. Daucher M, Price DA, Brenchley JM, et al. Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells. J Virol 2008;82:4102-14.
36. Kattan T, MacNamara A, Rowan AG, et al. The avidity and lytic efficiency of the CTL response to HTLV-1. J Immunol 2009;182:5723-9.
37. Bangham CR. CTL quality and the control of human retroviral infections. Eur J Immunol 2009;39:1700-12.
38. Coulie PG, Connerotte T. Human tumor-specific T lymphocytes: does function matter more than number? Curr Opin Immunol 2005;17:320-5.
39. Zhou J, Dudley ME, Rosenberg SA, Robbins PF. Selective growth, in vitro and in vivo, of individual T cell clones from tumor-infiltrating lymphocytes obtained from patients with melanoma. J Immunol 2004;173:7622-9. (Pubitemid 39628204)
40. thor Straten P, Kirkin AF, Siim E, et al. Tumor infiltrating lymphocytes in melanoma comprise high numbers of T-cell clonotypes that are lost during in vitro culture. Clin Immunol 2000;96:94-9.
41. Polz MF, Cavanaugh CM. Bias in template-to-product ratios in multi-template PCR. Appl Environ Microbiol 1998;64:3724-30.
42. Cameron TO, Cohen GB, Islam SA, Stern LJ. Examination of the highly diverse CD4(+) T-cell repertoire directed against an influenza peptide: a step towards TCR proteomics. Immunogenetics 2002;54:611-20.
43. Price DA, Brenchley JM, Ruff LE, et al. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J Exp Med 2005;202:1349-61.
44. Wlodarski MW, O'Keefe C, Howe EC, et al. Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia. Blood 2005;106:2769-80.
45. Plasilova M, Risitano AM, O'Keefe CL, et al. Shared and individual specificities of immunodominant cytotoxic T-cell clones in paroxysmal nocturnal hemoglobinuria as determined by molecular analysis. Exp Hematol 2004;32:261-9. (Pubitemid 38328531)
46. Zafiropoulos A, Barnes E, Piggott C, Klenerman P. Analysis of 'driver' and 'passenger' CD8+ T-cell responses against variable viruses. Proc Biol Sci 2004;271:S53-6.
47. Asquith B, Bangham CR. How does HTLV-I persist despite a strong cell-mediated immune response? Trends Immunol 2008;29:4-11.