Establishment of a seronegative human T-cell leukemia virus type 1 (HTLV-1) carrier state in rats inoculated with a syngeneic HTLV-1- immortalized T-cell line preferentially expressing tax

Journal of Virology

Volumn 73, Issue 8, 1999, Pages 6436-6443

  Koya, Yoshihiro ^a   Ohashi, Takashi ^a   Kato, Hirotomo ^a   Hanabuchi, Shino ^a   Tsukahara, Tomonori ^a   Takemura, Fumiyo ^a,b   Etoh, Ken Ichiro ^c   Matsuoka, Masao ^c   Fujii, Masahiro ^a,d   Kannagi, Mari ^a,b  

^a Medical Research Division ^*  (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^d NIIGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MITOMYCIN C;

ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; CELL IMMORTALIZATION; DNA FLANKING REGION; GENE ACTIVATION; HUMAN T CELL LEUKEMIA VIRUS 1; INOCULATION; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; RAT; SEROCONVERSION; TRANSACTIVATION; VIRUS CARRIER; VIRUS INFECTION; VIRUS REPLICATION;

EID: 0032798427     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.8.6436-6443.1999     Document Type: Article

References (56)

1. Aono, Y., J. Imai, K. Tominaga, S. Orita, A. Sato, and H. Igarashi. 1992. Rapid, sensitive, specific, and quantitative detection of human T-cell leukemia virus type 1 sequence in peripheral blood mononuclear cells by an improved polymerase chain reaction method with nested primers. Virus Genes 4:159-171.
2. Berneman, Z. N., R. B. Gartenhaus, M. S. Reitz, Jr., W. A. Blattner, A. Manns, B. Hanchard, O. Ikehara, R. C. Gallo, and M. E. Klotman. 1992. Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers. Proc. Natl. Acad. Sci. USA 89:3005-3009.
3. Bhat, N. K., Y. Adachi, K. P. Samuel, and D. Derse. 1993. HTLV-1 gene expression by defective proviruses in an infected T-cell line. Virology 196: 15-24
4. I reduces viral infectivity in vivo. Blood 91:4701-4707.
5. el-Farrash, M. A., H. A. Salem, M. J. Kuroda, K. Morizono, M. Kannagi, and S. Harada. 1995. Isolation of human T-cell leukemia virus type I from a transformed T-cell line derived spontaneously from lymphocytes of a sero-negative Egyptian patient with mycosis fungoides. Blood 86:1842-1849.
6. Etoh, K., S. Tamiya, K. Yamaguchi, A. Okayama, H. Tsubouchl, T. Ideta, N. Mueller, K. Takatsuki, and M. Matsuoka. 1997. Persistent clonal proliferation of human T-lymphotropic virus type I-infected cells in vivo. Cancer Res. 57:4862-4867.
7. Fujii, M., P. Sassone-Corsi, and I. M. Verma. 1988. c-fos promoter transactivation by the taxi protein of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 85:8526-8530.
8. Furukawa, Y., J. Fujisawa, M. Osame, M. Toita, S. Sonoda, R. Kubota, S. Ijichi, and M. Yoshida. 1992. Frequent clonal proliferation of human T-cell leukemia virus type 1 (HTLV-1)-infected T cells in HTLV-1-associated myelopathy (HAM-TSP). Blood 80:1012-1016.
9. Gessain, A., F. Barin, J. C. Vernant, O. Gout, L. Maurs, A. Calender, and G. de The. 1985. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 2:407-410.
10. Gessain, A., A. Louie, O. Gout, R. C. Gallo, and G. Franchini. 1991. Human T-cell leukemia-lymphona virus type I (HTLV-I) expression in fresh peripheral blood mononuclear cells from patients with tropical spastic paraparesis/HTLV-I-associated myelopathy. J. Virol. 65:1628-1633.
11. Ghosh, S. K., J. T. Abrams, H. Terunuma, E. C. Vonderheid, and E. DeFreitas. 1994. Human T-cell leukemia virus type I tax/rex DNA and RNA in cutaneous T-cell lymphoma. Blood 84:2663-2671.
12. Hall, W. W., C. R. Liu, O. Schneewind, H. Takahashi, M. H. Kaplan, G. Roupe, and A. Vahlne. 1991. Deleted HTLV-I provirus in blood and cutaneous lesions of patients with mycosis fungoides. Science 253:317-320.
13. Hattori, T., T. Uchiyama, T. Toibana, K. Takatsuki, and H. Uchino. 1981. Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood 58:645-647.
14. Hinuma, Y., K. Nagata, M. Hanaoka, M. Nakai, T. Matsumoto, K. I. Kinoshita, S. Shirakawa, and I. Miyoshi. 1981. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc. Natl. Acad. Sci. USA 78:6476-6480.
15. Ibrahim, F., L. Flette, A. Gessain, N. Buisson, G. de-The, and R. Bomford. 1994. Infection of rats with human T-cell leukemia virus type-I: susceptibility of inbred strains, antibody response and provirus location. Int. J. Cancer 58:446-451.
16. Inoue, J., M. Seiki, T. Taniguchi, S. Tsuru, and M. Yoshida. 1986. Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J. 5:2883-2888.
17. Ishiguro, N., M. Abe, K. Seto, H. Sakurai, H. Ikeda, A. Wakisaka, T. Togashi, M. Tateno, and T. Yoshiki. 1992. A rat model of human T lymphocyte virus type I (HTLV-I) infection. 1. Humoral antibody response, provirus integration, and HTLV-I-associated myelopathy/tropical spastic paraparesis-like myelopathy in seronegative HTLV-I carrier rats. J. Exp. Med. 176:981-989.
18. + cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature 148:245-248.
19. + cytotoxic T cells directed against HTLV-I infected cells. Int. Immunol. 3:761-767.
20. Kannagi, M., S. Matsushita, and S. Harada. 1993. Expression of the target antigen for cytotoxic T lymphocytes on adult T-cell leukemia cells. Int. J. Cancer 54:582-588.
21. Kannagi, M., K. Sugamura, K. Kinoshita, H. Uchino, and Y. Hinuma. 1984. Specific cytolysis of fresh tumor cells by an autologous killer T-cell line derived from an adult T-cell leukemia/lymphoma patient. J. Immunol. 133: 1037-1041.
22. Kato, H., Y. Koya, T. Ohashi, S. Hanabuchi, F. Takemura, M. Fujii, H. Tsujimoto, A. Hasegawa, and M. Kannagi. 1998. Oral administration of human T-cell leukemia virus type 1 induces immune unresponsiveness with persistent infection in adult rats. J. Virol. 72:7289-7293.
23. Kazanji, M., F. Ibrahim, L. Fiette, R. Bomford, and G. De The. 1997. Role of the genetic background of rats in infection by HTLV-I and HTLV-II and in the development of associated diseases. Int. J. Cancer 73:131-136.
24. Kim, S. J., J. H. Kehrl, J. Burton, C. L. Tendler, K. T. Jeang, D. Danielpour, C. Thevenin, K. Y. Kim, M. B. Sporn, and A. B. Roberts. 1990. Transactivation of the transforming growth factor beta 1 (TGP-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia. J. Exp. Med. 172:121-129.
25. Kinoshita, T., M. Shimoyama, K. Tobinai, M. Ito, S. Ito, S. Ikeda, K. Tajima, K. Shimotohno, and T. Sugimura. 1989. Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 86:5620-5624.
26. Kira, J., K. Yamasaki, I. Yamamoto, H. Mizusawa, S. Yoshino, S. Kusunoki, T. Yoshida, Y. Koyanagi, Y. Tanaka, Y. Kawano, M. Nakamura, M. Tsuneyoshi, N. Yamamoto, and T. Kobayashi. 1997. Induction of chronic inflammatory arthropathy and mesenchymal tumors in rats infected with HTLV-I. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 16:380-392.
27. Konishi, H., N. Kobayashi, and M. Hatanaka. 1984. Defective human T-cell leukemia virus in adult T-cell leukemia patients. Mol. Biol. Med. 2:273-283.
28. Kushida, S., H. Mizusawa, M. Matsumura, H. Tanaka, Y. Ami, M. Hori, K. Yagami, T. Kameyama, Y. Tanaka, A. Yoshida, H. Nyunoya, K. Shimotohno, Y. Iwasaki, K. Uchida, and M. Miwa. 1994. High incidence of HAM/TSP-like symptoms in WKA rats after administration of human T-cell leukemia virus type 1-producing cells. J. Virol. 68:7221-7226.
29. Lairmore, M. D., B. Roberts, D. Frank, J. Rovnak, M. G. Weiser, and G. L. Cockerell. 1992. Comparative biological responses of rabbits infected with human T-lymphotropic virus type I isolates from patients with lymphoproliferative and neurodegenerative disease. Int. J. Cancer 50:124-130.
30. Manca, N., E. Piacentini, M. Gelmi, P. Calzavara, M. A. Manganoni, A. Glukhov, F. Gargiulo, M. De Francesco, F. Pirali, G. De Panfilis, and A. Turano. 1994. Persistence of human T cell lymphotropic virus type 1 (HTLV-1) sequences in peripheral blood mononuclear cells from patients with mycosis fungoides. J. Exp. Med. 180:1973-1978.
31. Manzari, V., F. Wong-Staal, G. Franchini, S. Colombini, E. P. Gelmann, S. Oroszlan, S. Staal, and R. C. Gallo. 1983. Human T-cell leukemia-lymphoma virus (HTLV): cloning of an integrated defective provirus and flanking cellular sequences. Proc. Natl. Acad. Sci. USA 80:1574-1578.
32. Matsumoto, K., K. Akashi, H. Shibata, M. Yutsudo, and A. Hakura. 1994. Single amino acid substitution (58Pro→Ser) in HTLV-I tax results in loss of ras cooperative focus formation in rat embryo fibroblasts. Virology 200:813-815.
33. Miyatake, S., M. Seiki, R. D. Malefijt, T. Heike, J. Fujisawa, Y. Takebe, J. Nishida, J. Shlomai, T. Yokota, M. Yoshida, K. Arai, and N. Arai. 1988. Activation of T cell-derived lymphokine genes in T cells and fibroblasts: effects of human T cell leukemia virus type I p40x protein and bovine papilloma virus encoded E2 protein. Nucleic Acids Res. 16:6547-6566.
34. Miyoshi, I., I. Kubonishi, S. Yoshimoto, T. Akagi, Y. Ohtsuki, Y. Shiraishi, K. Nagala, and Y. Hinuma. 1981. Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature 294:770-771.
35. Niitsu, Y., Y. Urushizaki, Y. Koshida, K. Terui, K. Mahara, Y. Kohgo, and I. Urushizaki. 1988. Expression of TGF-beta gene in adult T cell leukemia. Blood 71:263-266.
36. Osame, M., K. Usuku, S. Izumo, N. Ijichi, H. Amitani, A. Igata, M. Matsumoto, and M. Tara. 1986. HTLV-I associated myelopathy, a new clinical entity. Lancet i:1031-1032. (Letter.)
37. Pancake, B. A., D. Zucker-Franklin, and E. E. Coutavas. 1995. The cutaneous T cell lymphoma, mycosis fungoides, is a human T cell lymphotropic virus-associated disease. A study of 50 patients. J. Clin. Invest. 95:547-554.
38. Poiesz, B. J., F. W. Ruscetti, A. F. Gazdar, P. A. Bunn, J. D. Minna, and R. C. Gallo. 1980. Detection and isolation of type cretrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA 77:7415-7419.
39. Robert-Guroff, M., Y. Nakao, K. Notake, Y. Ito, A. Sliski, and R. C. Gallo. 1982. Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T cell leukemia. Science 215:975-978.
40. Sahai Srivastara, B. I., and J. Minowada. 1973. Terminal deoxynucleotidyl transferase activity in a cell line (molt-4) derived from the peripheral blood of a patient with acute lymphoblastic leukemia. Biochem. Biophys. Res. Commun. 51:529-535.
41. Seiki, M., S. Hattori, Y. Hirayama, and M. Yoshida. 1983. Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc. Natl. Acad. Sci. USA 80:3618-3622.
42. Suga, T., T. Kameyama, T. Kinoshita, K. Shimotohno, M. Matsumura, H. Tanaka, S. Kushida, Y. Ami, M. Uchida, K. Uchida, and M. Miwa. 1991. Infection of rats with HTLV-1: a small-animal model for HTLV-1 carriers. Int. J. Cancer 49:764-769.
43. Sugamura, K., M. Fujii, M. Kannagi, M. Sakitani, M. Takeuchi, and Y. Hinuma. 1984. Cell surface phenotypes and expression of viral antigens of various human cell lines carrying human T-cell leukemia virus. Int. J. Cancer 34:221-228.
44. Takemoto, S., M. Matsuoka, K. Yamaguchi, and K. Takatsuki. 1994. A novel diagnostic method of adult T-cell leukemia: monoclonal integration of human T-cell lymphotropic virus type I provirus DNA detected by inverse polymerase chain reaction. Blood 84:3080-3085.
45. Tamiya, S., M. Matsuoka, K. Etoh, T. Watanabe, S. Kamihira, K. Yamaguchi, and K. Takatsuki. 1996. Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia. Blood 88:3065-3073.
46. Tanaka, Y., Y. Koyanagi, T. Chosa, N. Yamamoto, and Y. Hinuma. 1983. Monoclonal antibody reactive with both p28 and p19 of adult T-cell leukemia virus-specific polypeptides. Gann 74:327-330.
47. Tanaka, Y., M. Masuda, A. Yoshida, H. Shida, H. Nyunoya, K. Shimotohno, and H. Tozawa. 1992. An antigenic structure of the trans-activator protein encoded by human T-cell leukemia virus type-I (HTLV-I), as defined by a panel of monoclonal antibodies. Acquired Immune Defic. Syndr. Res. Hum. Retroviruses 8:227-235.
48. Tanaka, Y., R. Tanaka, E. Terada, Y. Koyanagi, N. Miyano-Kurosaki, N. Yamamoto, E. Baba, M. Nakamura, and H. Shida. 1994. Induction of antibody responses that neutralize human T-cell leukemia virus type I infection in vitro and in vivo by peptide immunization. J. Virol. 68:6323-6331.
49. Tanaka, Y., M. Yasumoto, H. Nyunoya, T. Ogura, M. Kikuchi, K. Shimotohno, H. Shiraki, N. Kuroda, H. Shida, and H. Tozawa. 1990. Generation and characterization of monoclonal antibodies against multiple epitopes on the C-terminal half of envelope gp46 of human T-cell leukemia virus type-I (HTLV-I). Int. J. Cancer 46:675-681.
50. Tateno, M., N. Kondo, T. Itoh, T. Chubachi, T. Togashi, and T. Yoshiki. 1984. Rat lymphoid cell lines with human T cell leukemia virus production. I. Biological and serological characterization. J. Exp. Med. 159:1105-1116.
51. Tendler, C. L., S. J. Greenberg, W. A. Blattner, A. Manns, E. Murphy, T. Fleisher, B. Hanchard, O. Morgan, J. D. Burton, D. L. Nelson, and T. A. Waldmann. 1990. Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy. Proc. Natl, Acad. Sci. USA 87:5218-5222.
52. Uchiyama, T., J. Yodoi, K. Sagawa, K. Takatsuki, and H. Uchino. 1977. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 50:481-492.
53. Villiger, P. M., M. T. Cronin, T. Amenomori, W. Wachsman, and M. Lotz. 1991. IL-6 production by human T lymphocytes. Expression in HTLV-1-infected but not in normal T cells. J. Immunol. 146:550-559.
54. Wano, Y., T. Hattori, M. Matsuoka, K. Takatsuki, A. O. Chua, U. Gubler, and W. C. Greene. 1987. Interleukin 1 gene expression in adult T cell leukemia. J. Clin. Invest. 80:911-916.
55. Yoshida, M., M. Osame, H. Kawal, M. Toita, N. Kuwasaki, Y. Nishida, Y. Hiraki, K. Takahashi, K. Nomura, S. Sonoda, N. Eiraku, S. Ijichi, and K. Usuku. 1989. Increased replication of HTLV-I in HTLV-I-associated myelopathy. Ann. Neurol. 26:331-335.
56. Yoshida, M., M. Seiki, K. Yamaguchi, and K. Takatsuki. 1984. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc. Natl. Acad. Sci. USA 81:2534-2537.