Cell-based delivery systems: Development of encapsulated cell technology for ophthalmic applications

Intraocular Drug Delivery

Volumn , Issue , 2006, Pages 111-128

  Tao, Weng ^a   Wen, Rong ^b   Laties, Alan ^b   Aguirre, Gustavo D ^c  

^a Neurotech USA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77955356375     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (33)

1. Aebischer P, Buchser E, Joseph JM, et al. Transplantation in humans of encapsulated xenogeneic cells without immunosuppression. A preliminary report. Transplantation 1994; 58:1275-1277.
2. Aebischer P, Schluep M, Deglon N, et al. Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nat Med 1996; 2:696-699.
3. Lindner MD, Kearns CE, Winn SR, Frydel B, Emerich DF. Effects of intraventricular encapsulated hNGF-secreting fibroblasts in aged rats. Cell Transplant 1996; 5: 205-223.
4. Emerich DF, Lindner MD, Winn SR, Chen EY, Frydel BR, Kordower JH. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington’s disease. J Neurosci 1996; 16:5168-5181.
5. Emerich DF, Winn SR, Hantraye PM, et al. Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington’s disease. Nature 1997; 386:395-399.
6. Emerich DF, Plone M, Francis J, Frydel BR, Winn SR, Lindner MD. Alleviation of behavioral deficits in aged rodents following implantation of encapsulated GDNFproducing fibroblasts. Brain Res 1996; 736:99-110.
7. Tseng JL, Baetge EE, Zurn AD, Aebischer P. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. J Neurosci 1997; 17:325-333.
8. Emerich DF, Hammang JP, Baetge EE, Winn SR. Implantation of polymer-encapsulated human nerve growth factor-secreting fibroblasts attenuates the behavioral and neuropathological consequences of quinolinic acid injections into rodent striatum. Exp Neurol 1994; 130:141-150.
9. Emerich DF, Winn SR, Harper J, Hammang JP, Baetge EE, Kordower JH. Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons. J Comp Neurol 1994; 349:148-164.
10. Kordower JH, Winn SR, Liu YT, et al. The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor. Proc Natl Acad Sci USA 1994; 91:10,898-10,902.
11. Tao W, Wen R, Goddard MB, et al. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 2002; 43:3292-3298.
12. Cedarbaum JM, Chapman C, Charatan M, et al. The pharmacokinetics of subcutaneously administered recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis: relation to parameters of the acute-phase response. The ALS CNTF treatment study (ACTS) phase I-II study group. Clin Neuropharmacol 1995; 18:500-514.
13. Cedarbaum JM. A phase I study of recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis. The ALS CNTF treatment study (ACTS) phase I-II study group. Clin Neuropharmacol 1995; 18:515-532.
14. Hoane MR, Puri KD, Xu L, et al. Mammalian-cell-produced neurturin (NTN) is more potent than purified escherichia coli-produced NTN. Exp Neurol 2000; 162:189-193.
15. LaVail MM, Yasumura D, Matthes MT, et al. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 1998; 39:592-602.
16. Van Adel BA, Kostic C, Deglon N, Ball AK, Arsenijevic Y. Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time. Hum Gene Ther 2003; 14:103-115.
17. Watanabe M, Fukuda Y. Survival and axonal regeneration of retinal ganglion cells in adult cats. Prog Retin Eye Res 2002; 21:529-553.
18. Agarwal N, Martin E, Krishnamoorthy RR, et al. Levobetaxolol-induced up-regulation of retinal bFGF and CNTF mRNAs and preservation of retinal function against a photic-induced retinopathy. Exp Eye Res 2002; 74:445-453.
19. Bedell MA, Largaespada DA, Jenkins NA, Copeland NG. Mouse models of human disease. Part II: recent progress and future directions. Genes Dev 1997; 11:11-43.
20. LaVail MM, Sidman M, Rausin R, Sidman RL. Discrimination of light intensity by rats with inherited retinal degeneration: a behavioral and cytological study. Vision Res 1974; 14:693-702.
21. Bowes C, Li T, Danciger M, Baxter LC, Applebury ML, Farber DB. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature 1990; 347:677-680.
22. Pittler SJ, Baehr W, Wasmuth JJ, et al. Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene. Genomics 1990; 6:272-283.
23. Suber ML, Pittler SJ, Qin N, et al. Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene. Proc Natl Acad Sci USA 1993; 90:3968-3972.
24. McLaughlin ME, Ehrhart TL, Berson EL, Dryja TP. Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa. Proc Natl Acad Sci USA 1995; 92:3249-3253.
25. Liu C, Li Y, Peng M, Laties AM, Wen R. Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration. J Neurosci 1999; 19:4778-4785.
26. Aguirre GF, Farber D, Lolley R, et al. Retinal degenerations in the dog III abnormal cyclic nucleotide metabolism in rod-cone dysplasia. Exp Eye Res 1982; 35:625-642.
27. Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 1990; 347:83-86.
28. LaVail MM, Unoki K, Yasumura D, Matthes MT, Yancopoulos GD, Steinberg RH. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci USA 1992; 89:11249-11253.
29. Steinberg RH. Survival factors in retinal degenerations. Curr Opin Neurobiol 1994; 4:515-524.
30. Unoki K, LaVail MM. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Invest Ophthalmol Vis Sci 1994; 35:907-915.
31. Ray K, Baldwin VJ, Acland GM, Blanton SH, Aguirre GD. Cosegregation of codon 807 mutation of the canine rod cGMP phosphodiesterase beta gene and rcd1. Invest Ophthalmol Vis Sci 1994; 35:4291-4299.
32. Schmidt SY, Aguirre GD. Reductions in taurine secondary to photoreceptor loss in Irish setters with rod-cone dysplasia. Invest Ophthalmol Vis Sci 1985; 26:679-683.
33. Thanos CG, Bell WJ, O’Rourke P, et al. Sustained secretion of ciliary neuro factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular devices. Tissue Eng 2004; 10(11/12):1617-1622.