Sustained secretion of ciliary neurotrophic factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular device

Tissue Engineering

Volumn 10, Issue 11-12, 2004, Pages 1617-1622

  Thanos, Christopher G ^a   Bell, William J ^a   O'Rourke, P ^a   Kauper, Konrad ^a   Sherman, Sandy ^a   Stabila, Paul ^a   Tao, Weng ^a  

^a Neurotech USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENCAPSULATION; NUTRITION; POPULATION STATISTICS; PROTEINS; REGRESSION ANALYSIS;

CILIARY NEUROTROPHIC FACTOR (CNTF); ENCAPSULATED CELL THERAPY (ECT); VIVO OUTPUT;

CELL CULTURE;

ACRYLIC ACID DERIVATIVE; ADHESIVE AGENT; CILIARY NEUROTROPHIC FACTOR; COPOLYMER; POLYETHERSULFONE; POLYETHYLENE TEREPHTHALATE; TITANIUM; UNCLASSIFIED DRUG; URETHANE ACRYLATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCULATION; CELL ENCAPSULATION; CELL LINE; CONTROLLED DRUG RELEASE; CULTURE MEDIUM; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; HALF LIFE TIME; NONHUMAN; NT 501 INTRAOCULAR DEVICE; PRIORITY JOURNAL; PROTEIN SECRETION; RABBIT; REGRESSION ANALYSIS; SAFETY; SYRINGE; TIME; VITREOUS BODY;

EID: 11144232135     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2004.10.1617     Document Type: Article

References (15)

1. Boughman, J., Conneally, P., and Nance, W. Population genetic studies of retinitis pigmentosa. Am. J. Hum. Genet. 32, 223, 1980.
2. Farrar G., Kenna, P., and Humphries, P. On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention. EMBO J. 21, 5, 2002.
3. Cayouette, M., and Gravel, C. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum. Gene Ther. 8, 4, 1997.
4. Cayouette, M., Behn, D., Sendtner, M., et al. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J. Neurosci. 18, 22, 1998.
5. LaVail, M., Yasumura, D., Matthes, M., et al. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest. Ophthalmol. Vis. Sci. 39, 3, 1998.
6. Tao, W., Wen, R., Goddard, M., et al. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 43, 10, 2002.
7. Dittrich, F., Thoenen, H., and Sendtner, M. Ciliary neurotrophic factor: Pharmacokinetics and the acute-phase response in the rat. Ann. Neurol. 35, 151, 1994.
8. Tan, S., Deglon, N., Zurn, A., et al. Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF. Cell Transplant. 5, 5, 1996.
9. Cedarbaum, J., Chapman, C., Charatan, M., et al. The pharmacokinetics of subcutaneously administered recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis: Relation to parameters of the acute-phase response. Clin. Neuropharmacol. 18, 6, 1995.
10. Herrero-Vanrell, R., and Refojo, M. Biodegradable microspheres for vitreoretinal drug delivery. Adv. Drug Deliv. Rev. 52, 1, 2001.
11. Yasukawa, T., Kimura, H., Kunou, N., et al. Biodegradable scleral implant for intravitreal controlled release of ganciclovir. Graefes Arch. Clin. Exp. Ophthalmol. 238, 2, 2000.
12. Martin, D., Dunn, J., Davis, J., et al. Use of the ganciclovir implant for the treatment of cytomegalovirus retinitis in the era of potent antiretroviral therapy: Recommendations of the International AIDS Society-USA panel. Am. J. Ophthalmol. 127, 3, 1999.
13. Geroski, D., and Edelhauser, H. Transscleral drug delivery for posterior segment disease. Adv. Drug Deliv. Rev. 52, 2001.
14. Arshinoff, S., Opalinski, Y., and Ma, J. The lens. In Yanoff, M., and Duker, J., eds. Ophthalmology. London: Mosby International, 1999.
15. Meyer, C., Notari, L., and Becerra, S. Mapping the type I collagen-binding site on pigment epithelium-derived factor: Implications for its antiangiogenic activity. J. Biol. Chem. 277, 47, 2002.