Essential fatty acids and their metabolites in the context of hypertension

Hypertension Research

Volumn 33, Issue 8, 2010, Pages 782-785

  Das, Undurti N ^a,b  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^b UND LIFE SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; ARACHIDONIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CD59 ANTIGEN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOCOSAHEXAENOIC ACID; EXTRACELLULAR SUPEROXIDE DISMUTASE; FREE RADICAL; HYDROGEN PEROXIDE; ICOSAPENTAENOIC ACID; LEPTIN; LINOLENIC ACID; LIPID PEROXIDE; LIPOXIN; MYELOPEROXIDASE; NITRIC OXIDE; OMEGA 3 FATTY ACID; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PROSTACYCLIN; PROSTAGLANDIN E1; PROSTAGLANDIN I3; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TETRAHYDROBIOPTERIN; THROMBOXANE A2; TUMOR NECROSIS FACTOR ALPHA;

ADRENERGIC SYSTEM; BIOAVAILABILITY; BLOOD PRESSURE; BLOOD VESSEL TONE; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ESSENTIAL HYPERTENSION; HUMAN; HYPERTENSION; HYPOTHALAMUS; INSULIN RESISTANCE; LEUKOCYTE ACTIVATION; NEUTROPHIL; NONHUMAN; NOTE; NUTRITION; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; SMOOTH MUSCLE; T LYMPHOCYTE ACTIVATION; VASCULAR RESISTANCE; VASCULITIS;

ANIMALS; DIETARY FATS, UNSATURATED; FATTY ACIDS, ESSENTIAL; HUMANS; HYPERTENSION; OXIDATIVE STRESS; VASCULAR RESISTANCE;

EID: 77955342510     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2010.105     Document Type: Note

References (35)

1. Das UN. Interaction(s) of polyunsaturated fatty acids with dietary protein and its relationship to the pathogenesis of hypertension. Am J Hypertens 2010; 23: 111-112.
2. Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM. Dietary approaches to prevent and treat hypertension. A scientific statement from the American Heart Association. Hypertension 2006; 47: 296-308.
3. Weisinger HS, Armitage JA, Sinclair AJ, Vingrys AJ, Burns PL, Weisinger RS. Perinatal omega-3 fatty acid deficiency affects blood pressure later in life. Nat Med 2001; 7: 258-259.
4. Li D, Weisinger HS, Weisinger RS, Mathai M, Armitage JA, Vingrys AJ, Sinclair AJ. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. Prostaglandins Leukot Essent Fatty Acids 2006; 74: 391-399.
5. Begg DP, Sinclair AJ, Stahl LA, Premaratna SD, Hafandi A, Jois M, Weisinger RS. Hypertension induced by o-3 polyunsaturated fatty acid deficiency is alleviated by a-linolenic acid regardless of dietary source. Hypertens Res 2010; 33: 808-813.
6. Das UN. Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids. Wiley-Blackwell: Iowa, USA, 2010.
7. Kumar KV, Das UN. Are free radicals involved in the pathobiology of human essential hypertension? Free Rad Res Commun 1993; 19: 59-66.
8. Suryaprabha P, Das UN, Koratkar R, Sangeetha P, Ramesh G. Free radical generation, lipid peroxidation and essential fatty acids in uncontrolled hypertension. Prostaglandins Leukot Essen Fatty Acids 1990; 41: 27-33.
9. Katusic ZS, Vanhoutte PM. Superoxide anion is an endothelium derived contracting factor. Am J Physiol 1989; 257: 433-437.
10. Nakazono L, Watanabe N, Matsuno K, Sasaki J, Sato T, Inoue M. Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci USA 1991; 88: 10045-10048.
11. Jun T, Ke-yan F, Catalano M. Increased superoxide anion production in humans: a possible mechanism for the pathogenesis of hypertension. J Hum Hypertens 1996; 10: 305-309.
12. Wolf G. Free radical production and angiotensin. Curr Hypertens Rep 2000; 2: 167-173.
13. Zhang H, Schmeisser A, Garlichs CD, Plotze K, Damme U, Mugge A, Daniel WG. Angiotensin II-induced superoxide anion generation in human vascular endothelial cells: role of membrane-bound NADH-NAD(P)H-oxidases. Cardiovasc Res 1999; 44: 215-222.
14. Lob HE, Marvar PJ, Guzik TJ, Sharma S, McCann LA, Weyand C, Gordon FJ, Harrison DG. Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension 2010; 55: 277-283.
15. Retailleau K, Belin de Chantemèle EJ, Chanoine S, Guihot AL, Vessières E, Toutain B, Faure S, Bagi Z, Loufrani L, Henrion D. Reactive oxygen species and cyclooxygenase 2-derived thromboxane A2 reduce angiotensin II type 2 receptor vasorelaxation in diabetic rat resistance arteries. Hypertension 2010; 55: 339-344.
16. Mazor R, Itzhaki O, Sela S, Yagil Y, Cohen-Mazor M, Yagil C, Kristal B. Tumor necrosis factor-alpha: a possible priming agent for the polymorphonuclear leukocyte-reduced nicotinamide-adenine dinucleotide phosphate oxidase in hypertension. Hypertension 2010; 55: 353-362.
17. Walker AE, Seibert SM, Donato AJ, Pierce GL, Seals DR. Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults. Hypertension 2010; 55: 363-369.
18. Das UN. Essential fatty acid metabolism in patients with essential hypertension, diabetes mellitus and coronary heart disease. Prostaglandins Leukot Essent Fatty Acids 1995; 52: 387-391.
19. Holm T, Andreassen AK, Aukrust P, Andersen K, Geiran OR, Kjekshus J, Simonsen S, Gullestad L. Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipients. Eur Heart J 2001; 22: 428-436.
20. Mori TA, Bao DQ, Burke V, Puddey IB, Beilin LJ. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 1999; 34: 253-260.
21. Toft I, Bønaa KH, Ingebretsen OC, Nordøy A, Jenssen T. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995; 123: 911-918.
22. Das UN. Nutritional factors in the pathobiology of human essential hypertension. Nutrition 2001; 17: 337-346.
23. Kumar KV, Das UN. Effect of cis-unsaturated fatty acids, prostaglandins, and free radicals on angiotensin converting enzyme activity in vitro. Proc Exp Biol Med 1997; 214: 374-379.
24. McVeigh GE, Brennan GM, Johnson GD, McDermott BJ, McGrath LT, Henry WR, Andrews JW, Hayes JR. Dietary fish oil augments nitric oxide production or release in patients with type 2 (non-insulin dependent) diabetes mellitus. Diabetologia 1993; 36: 33-38.
25. Okuda Y, Kawashima K, Sawada T, Tsurumaru K, Asano M, Suzuki S, Soma M, Nakajima T, Yamashita K. Eicosapentaenoic acid enhances nitric oxide production by cultured human endothelial cells. Biochem Biophys Res Commun 1997; 232: 487-491.
26. Das UN. Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. Lipids Health Dis 2008; 7: 37.
27. Serhan CN. Systems approach to inflammation resolution: identification of novel anti-inflammatory and pro-resolving mediators. J Thromb Haemost 2009; 7 (Suppl 1): 44-48.
28. Hagiwara S, Makita Y, Gu L, Tanimoto M, Zhang M, Nakamura S, Kaneko S, Itoh T, Gohda T, Horikoshi S, Tomino Y. Eicosapentaenoic acid ameliorates diabetic nephropathy of type 2 diabetic KKAy/Ta mice: involvement of MCP-1 suppression and decreased ERK1/2 and p38 phosphorylation. Nephrol Dial Transplant 2006; 21: 605-615.
29. Otero M, Lago R, Lago F, Casanueva FF, Dieguez C, Gómez-Reino JJ, Gualillo O. Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 2005; 579: 295-301.
30. Das UN. Hypertension as a low-grade systemic inflammatory condition that has its origins in the perinatal period. J Assoc Physicians India 2006; 54: 133-142.
31. Das UN. Leucocyte activation in coronary heart disease: but how and why? Eur Heart J 2008; 29: 2317-2318.
32. Das UN. Risk of type 2 diabetes mellitus in those with hypertension. Eur Heart J 2008; 29: 952-953.
33. Flierl MA, Rittirsch D, Nadeau BA, Chen AJ, Sarma JV, Zetoune FS, McGuire SR, List RP, Day DE, Hoesel LM, Gao H, Rooijen NV, Huber-Lang MS, Neubig RR, Ward PA. Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature 2007; 449: 721-725.
34. Das UN. Beneficial actions of polyunsaturated fatty acids in cardiovascular diseases: but, how and why? Curr Nutr Food Sci 2008; 4: 2031.
35. Favrelière S, Perault MC, Huguet F, De Javel D, Bertrand N, Piriou A, Durand G. DHA-enriched phospholipid diets modulate age-related alterations in rat hippocampus. Neurobiol Aging 2003; 24: 233-243.