2-Acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 5157-5171

  Kobayashi, Toshitake ^a   Sasaki, Satoshi ^a   Tomita, Naoki ^a   Fukui, Seiji ^a   Nakayama, Masaharu ^a   Kiba, Atsushi ^a   Kusaka, Masami ^a   Matsumoto, Shin Ichi ^a   Yamaguchi, Masashi ^a   Itoh, Fumio ^a   Baba, Atsuo ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

2 Acylamino 4,6 diphenylpyridine; GPR54 antagonist; Kisspeptin; Metastin

Indexed keywords

2 ACYLAMINO 4,6 DIPHENYLPYRIDINE DERIVATIVE; AMINE; BIPHENYL DERIVATIVE; G PROTEIN COUPLED RECEPTOR 54; GONADORELIN; GONADOTROPIN; LUTEINIZING HORMONE; METASTIN; N [3 CYANO 6 (4 FLUORO 2 HYDROXYPHENYL) 4 (3 PIPERAZIN 1 YLPHENYL)PYRIDIN 2 YL]FURAN 2 CARBOXAMIDE; PIPERAZINE; PYRIDINE DERIVATIVE; SEX HORMONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG EXPOSURE; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; IN VIVO STUDY; LIGAND BINDING; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

AMINOPYRIDINES; ANIMALS; BRAIN; CACO-2 CELLS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; LUTEINIZING HORMONE; MALE; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED;

RATTUS;

EID: 77955338335     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.061     Document Type: Article

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