메뉴 건너뛰기




Volumn 168, Issue 2, 2010, Pages 245-255

Aqueous leaf extracts display endocrine activities in vitro and disrupt sexual differentiation of male Xenopus laevis tadpoles in vivo

Author keywords

Aqueous leaf extracts; Development; Endocrine disruption; Sexual differentiation; Thyroid system; Xenopus laevis

Indexed keywords

ANDROGEN; ENDOCRINE DISRUPTOR; ESTROGEN; LUTEINIZING HORMONE BETA SUBUNIT; MESSENGER RNA; ORGANIC CARBON; SURFACE WATER;

EID: 77955337829     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2010.03.005     Document Type: Article
Times cited : (18)

References (56)
  • 1
    • 0023612656 scopus 로고
    • Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG)
    • Adlercreutz H., Hockerstedt K., Bannwart C., Bloigu S., Hamalainen E., Fotsis T., Ollus A. Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J. Steroid Biochem. 1987, 27:1135-1144.
    • (1987) J. Steroid Biochem. , vol.27 , pp. 1135-1144
    • Adlercreutz, H.1    Hockerstedt, K.2    Bannwart, C.3    Bloigu, S.4    Hamalainen, E.5    Fotsis, T.6    Ollus, A.7
  • 2
    • 7444265550 scopus 로고    scopus 로고
    • Evaluation of the model anti-androgen flutamide for assessing the mechanistic basis of responses to an androgen in the fathead minnow (Pimephales promelas)
    • Ankley G.T., Defoe D.L., Kahl M.D., Jensen K.M., Makynen E.A., Miracle A., Hartig P., Gray L.E., Cardon M., Wilson V. Evaluation of the model anti-androgen flutamide for assessing the mechanistic basis of responses to an androgen in the fathead minnow (Pimephales promelas). Environ. Sci. Technol. 2004, 38:6322-6327.
    • (2004) Environ. Sci. Technol. , vol.38 , pp. 6322-6327
    • Ankley, G.T.1    Defoe, D.L.2    Kahl, M.D.3    Jensen, K.M.4    Makynen, E.A.5    Miracle, A.6    Hartig, P.7    Gray, L.E.8    Cardon, M.9    Wilson, V.10
  • 4
    • 0344306680 scopus 로고    scopus 로고
    • The effects of vinclozolin, an anti-androgenic fungicide, on male guppy secondary sex characters and reproductive success
    • Bayley M., Larsen P.F., Baekgaard H., Baatrup E. The effects of vinclozolin, an anti-androgenic fungicide, on male guppy secondary sex characters and reproductive success. Biol. Reprod. 2003, 69:1951-1956.
    • (2003) Biol. Reprod. , vol.69 , pp. 1951-1956
    • Bayley, M.1    Larsen, P.F.2    Baekgaard, H.3    Baatrup, E.4
  • 5
    • 33646516819 scopus 로고    scopus 로고
    • Analysis of estrogenic activity in coastal surface waters of the Baltic Sea using the yeast estrogen screen
    • Beck I.C., Bruhn R., Gandrass J. Analysis of estrogenic activity in coastal surface waters of the Baltic Sea using the yeast estrogen screen. Chemosphere 2006, 63:1870-1878.
    • (2006) Chemosphere , vol.63 , pp. 1870-1878
    • Beck, I.C.1    Bruhn, R.2    Gandrass, J.3
  • 6
    • 1542378861 scopus 로고    scopus 로고
    • Carbon turnover in peatland mesocosms exposed to different water table levels
    • Blodau S., Basiliko N., Moore T.R. Carbon turnover in peatland mesocosms exposed to different water table levels. Biogeochemistry 2004, 67:331-351.
    • (2004) Biogeochemistry , vol.67 , pp. 331-351
    • Blodau, S.1    Basiliko, N.2    Moore, T.R.3
  • 7
    • 0036900973 scopus 로고    scopus 로고
    • Functional genomics and sexual differentiation in amphibians
    • Bögi C., Levy G., Lutz I., Kloas W. Functional genomics and sexual differentiation in amphibians. Comp. Biochem. Physiol. B 2002, 133:559-570.
    • (2002) Comp. Biochem. Physiol. B , vol.133 , pp. 559-570
    • Bögi, C.1    Levy, G.2    Lutz, I.3    Kloas, W.4
  • 9
    • 37349074356 scopus 로고    scopus 로고
    • Endocrine disrupting chemicals (EDC) with (anti)estrogenic and (anti)androgenic modes of action affecting reproductive biology of Xenopus laevis: II. Effects on gonad histomorphology
    • Cevasco A., Urbatzka R., Bottero S., Massari A., Pedemonte F., Kloas W., Mandich A. Endocrine disrupting chemicals (EDC) with (anti)estrogenic and (anti)androgenic modes of action affecting reproductive biology of Xenopus laevis: II. Effects on gonad histomorphology. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2008, 147:241-251.
    • (2008) Comp. Biochem. Physiol. C Toxicol. Pharmacol. , vol.147 , pp. 241-251
    • Cevasco, A.1    Urbatzka, R.2    Bottero, S.3    Massari, A.4    Pedemonte, F.5    Kloas, W.6    Mandich, A.7
  • 10
    • 71749111543 scopus 로고    scopus 로고
    • Identification of direct thyroid hormone response genes reveals the earliest gene regulation programs during frog metamorphosis
    • Das B., Heimeier R.A., Buchholz D.R., Shi Y.B. Identification of direct thyroid hormone response genes reveals the earliest gene regulation programs during frog metamorphosis. J. Biol. Chem. 2009, 284:34167-34178.
    • (2009) J. Biol. Chem. , vol.284 , pp. 34167-34178
    • Das, B.1    Heimeier, R.A.2    Buchholz, D.R.3    Shi, Y.B.4
  • 11
    • 0034874721 scopus 로고    scopus 로고
    • Optimization of a yeast estrogen screen and its applicability to study the release of estrogenic isoflavones from a soygerm powder
    • De Boever P., Demare W., Vanderperren E., Cooreman K., Bossier P., Verstraete W. Optimization of a yeast estrogen screen and its applicability to study the release of estrogenic isoflavones from a soygerm powder. Environ. Health Perspect. 2001, 109:691-697.
    • (2001) Environ. Health Perspect. , vol.109 , pp. 691-697
    • De Boever, P.1    Demare, W.2    Vanderperren, E.3    Cooreman, K.4    Bossier, P.5    Verstraete, W.6
  • 12
    • 0030898378 scopus 로고    scopus 로고
    • Inhibition of 5 alpha-reductase and aromatase by the ellagitannins oenothein A and oenothein B from Epilobium species
    • Ducrey B., Marston A., Gohring S., Hartmann R.W., Hostettmann K. Inhibition of 5 alpha-reductase and aromatase by the ellagitannins oenothein A and oenothein B from Epilobium species. Planta Med. 1997, 63:111-114.
    • (1997) Planta Med. , vol.63 , pp. 111-114
    • Ducrey, B.1    Marston, A.2    Gohring, S.3    Hartmann, R.W.4    Hostettmann, K.5
  • 13
    • 21344448186 scopus 로고    scopus 로고
    • Estrogenic agonism and antagonism of the soy isoflavone genistein in uterus, bone and lymphopoiesis in mice
    • Erlandsson M.C., Islander U., Moverare S., Ohlsson C., Carlsten H. Estrogenic agonism and antagonism of the soy isoflavone genistein in uterus, bone and lymphopoiesis in mice. APMIS 2005, 113:317-323.
    • (2005) APMIS , vol.113 , pp. 317-323
    • Erlandsson, M.C.1    Islander, U.2    Moverare, S.3    Ohlsson, C.4    Carlsten, H.5
  • 14
    • 0032192191 scopus 로고    scopus 로고
    • Feminisation of young males of the common carp, Cyprinus carpio, exposed to 4-tert-pentylphenol during sexual differentiation
    • Gimeno S., Komen H., Gerritsen A.G.M., Bowmer T. Feminisation of young males of the common carp, Cyprinus carpio, exposed to 4-tert-pentylphenol during sexual differentiation. Aquat. Toxicol. 1998, 43:77-92.
    • (1998) Aquat. Toxicol. , vol.43 , pp. 77-92
    • Gimeno, S.1    Komen, H.2    Gerritsen, A.G.M.3    Bowmer, T.4
  • 16
    • 0001162676 scopus 로고    scopus 로고
    • Size-exclusion-chromatography with organic carbon detection (LC-OCD): a fast and a reliable method for characterisation of hydrophilic organic matter in natural waters
    • Huber S.A., Frimmel F.H. Size-exclusion-chromatography with organic carbon detection (LC-OCD): a fast and a reliable method for characterisation of hydrophilic organic matter in natural waters. Vom Wasser 1996, 86:277-290.
    • (1996) Vom Wasser , vol.86 , pp. 277-290
    • Huber, S.A.1    Frimmel, F.H.2
  • 18
    • 18844441459 scopus 로고    scopus 로고
    • Steroid hormones regulate gene expression posttranscriptionally by altering the stabilities of messenger RNAs
    • Ing N.H. Steroid hormones regulate gene expression posttranscriptionally by altering the stabilities of messenger RNAs. Biol. Reprod. 2005, 72:1290-1296.
    • (2005) Biol. Reprod. , vol.72 , pp. 1290-1296
    • Ing, N.H.1
  • 19
    • 0038324428 scopus 로고    scopus 로고
    • Androstenedione and progesterone in the sediment of a river receiving paper mill effluent
    • Jenkins R.L., Wilson E.M., Angus R.A., Howell W.M., Kirk M. Androstenedione and progesterone in the sediment of a river receiving paper mill effluent. Toxicol. Sci. 2003, 73:53-59.
    • (2003) Toxicol. Sci. , vol.73 , pp. 53-59
    • Jenkins, R.L.1    Wilson, E.M.2    Angus, R.A.3    Howell, W.M.4    Kirk, M.5
  • 20
  • 21
    • 7444220540 scopus 로고    scopus 로고
    • Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow
    • Jensen K.M., Kahl M.D., Makynen E.A., Korte J.J., Leino R.L., Butterworth B.C., Ankley G.T. Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow. Aquat. Toxicol. 2004, 70:99-110.
    • (2004) Aquat. Toxicol. , vol.70 , pp. 99-110
    • Jensen, K.M.1    Kahl, M.D.2    Makynen, E.A.3    Korte, J.J.4    Leino, R.L.5    Butterworth, B.C.6    Ankley, G.T.7
  • 22
    • 34948867794 scopus 로고    scopus 로고
    • Acclimation of Ceratophyllum demersum to stress imposed by Phragmites australis and Quercus robur leaf extracts
    • Kamara S., Pflugmacher S. Acclimation of Ceratophyllum demersum to stress imposed by Phragmites australis and Quercus robur leaf extracts. Ecotoxicol. Environ. Saf. 2007, 68:335-342.
    • (2007) Ecotoxicol. Environ. Saf. , vol.68 , pp. 335-342
    • Kamara, S.1    Pflugmacher, S.2
  • 23
    • 0042698826 scopus 로고    scopus 로고
    • Effects of the isoflavones genistein and equol on the gonadal development of Japanese medaka Oryzias latipes
    • Kiparissis Y., Balch G.C., Metcalfe T.L., Metcalfe C.D. Effects of the isoflavones genistein and equol on the gonadal development of Japanese medaka Oryzias latipes. Environ. Health Perspect. 2003, 111:1158-1163.
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1158-1163
    • Kiparissis, Y.1    Balch, G.C.2    Metcalfe, T.L.3    Metcalfe, C.D.4
  • 24
    • 0033011061 scopus 로고    scopus 로고
    • Amphibians as a model to study endocrine disruptors: II. Estrogenic activity of environmental chemicals in vitro and in vivo
    • Kloas W., Lutz I., Einspanier R. Amphibians as a model to study endocrine disruptors: II. Estrogenic activity of environmental chemicals in vitro and in vivo. Sci. Total Environ. 1999, 225:59-68.
    • (1999) Sci. Total Environ. , vol.225 , pp. 59-68
    • Kloas, W.1    Lutz, I.2    Einspanier, R.3
  • 25
    • 33748715353 scopus 로고    scopus 로고
    • Amphibians as model to study endocrine disrupters
    • Kloas W., Lutz I. Amphibians as model to study endocrine disrupters. J. Chromatogr. A 2006, 1130:16-27.
    • (2006) J. Chromatogr. A , vol.1130 , pp. 16-27
    • Kloas, W.1    Lutz, I.2
  • 27
    • 0036057049 scopus 로고    scopus 로고
    • Male-biased sex ratios of fish embryos near a pulp mill: temporary recovery after a short-term shutdown
    • Larsson D.G., Forlin L. Male-biased sex ratios of fish embryos near a pulp mill: temporary recovery after a short-term shutdown. Environ. Health Perspect. 2002, 110:739-742.
    • (2002) Environ. Health Perspect. , vol.110 , pp. 739-742
    • Larsson, D.G.1    Forlin, L.2
  • 28
    • 34047178338 scopus 로고    scopus 로고
    • Androgen disruption of early development in Qurt strain medaka (Oryzias latipes)
    • Leon A., Teh S.J., Hall L.C., Teh F.C. Androgen disruption of early development in Qurt strain medaka (Oryzias latipes). Aquat. Toxicol. 2007, 82:195-203.
    • (2007) Aquat. Toxicol. , vol.82 , pp. 195-203
    • Leon, A.1    Teh, S.J.2    Hall, L.C.3    Teh, F.C.4
  • 29
    • 27644513796 scopus 로고    scopus 로고
    • Environmental signals: synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis
    • Lutz I., Jie Z., Opitz R., Kloas W., Ying X., Menzel R., Steinberg C.E. Environmental signals: synthetic humic substances act as xeno-estrogen and affect the thyroid system of Xenopus laevis. Chemosphere 2005, 61:1183-1188.
    • (2005) Chemosphere , vol.61 , pp. 1183-1188
    • Lutz, I.1    Jie, Z.2    Opitz, R.3    Kloas, W.4    Ying, X.5    Menzel, R.6    Steinberg, C.E.7
  • 30
    • 0141625063 scopus 로고    scopus 로고
    • Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds
    • MacKenzie C.A., Berrill M., Metcalfe C., Pauli B.D. Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds. Environ. Toxicol. Chem. 2003, 22:2466-2475.
    • (2003) Environ. Toxicol. Chem. , vol.22 , pp. 2466-2475
    • MacKenzie, C.A.1    Berrill, M.2    Metcalfe, C.3    Pauli, B.D.4
  • 31
    • 0032185372 scopus 로고    scopus 로고
    • Blocking of KC1O4-induced metamorphosis in premetamorphic sea lampreys by exogenous thyroid hormones (TH); effects of KC1O4 and TH on serum TH concentrations and intestinal thyroxine outer-ring deiodination
    • Manzon R.G., Eales J.G., Youson J.H. Blocking of KC1O4-induced metamorphosis in premetamorphic sea lampreys by exogenous thyroid hormones (TH); effects of KC1O4 and TH on serum TH concentrations and intestinal thyroxine outer-ring deiodination. Gen. Comp. Endocrinol. 1998, 112:54-62.
    • (1998) Gen. Comp. Endocrinol. , vol.112 , pp. 54-62
    • Manzon, R.G.1    Eales, J.G.2    Youson, J.H.3
  • 32
    • 0000898835 scopus 로고    scopus 로고
    • Leaf litter as a source of dissolved organic carbon in streams
    • Meyer J.L., Wallace J.B., Eggert L. Leaf litter as a source of dissolved organic carbon in streams. Ecosystems 1998, 1:240-249.
    • (1998) Ecosystems , vol.1 , pp. 240-249
    • Meyer, J.L.1    Wallace, J.B.2    Eggert, L.3
  • 34
    • 0003478757 scopus 로고
    • Garland Publishing, Inc., New York, P.D. Nieuwkoop, J. Faber (Eds.)
    • Normal Table of Xenopus laevis (Daudin) 1994, Garland Publishing, Inc., New York. P.D. Nieuwkoop, J. Faber (Eds.).
    • (1994) Normal Table of Xenopus laevis (Daudin)
  • 35
    • 33847217991 scopus 로고    scopus 로고
    • Novel phytoandrogens and lipidic augmenters from Eucommia ulmoides
    • Ong V.Y., Tan B.K. Novel phytoandrogens and lipidic augmenters from Eucommia ulmoides. BMC Complement. Altern. Med. 2007, 7:3.
    • (2007) BMC Complement. Altern. Med. , vol.7 , pp. 3
    • Ong, V.Y.1    Tan, B.K.2
  • 36
    • 13944272596 scopus 로고    scopus 로고
    • Description and initial evaluation of a Xenopus metamorphosis assay for detection of thyroid system-disrupting activities of environmental compounds
    • Opitz R., Braunbeck T., Bogi C., Pickford D.B., Nentwig G., Oehlmann J., Tooi O., Lutz I., Kloas W. Description and initial evaluation of a Xenopus metamorphosis assay for detection of thyroid system-disrupting activities of environmental compounds. Environ. Toxicol. Chem. 2005, 24:653-664.
    • (2005) Environ. Toxicol. Chem. , vol.24 , pp. 653-664
    • Opitz, R.1    Braunbeck, T.2    Bogi, C.3    Pickford, D.B.4    Nentwig, G.5    Oehlmann, J.6    Tooi, O.7    Lutz, I.8    Kloas, W.9
  • 37
    • 33645111277 scopus 로고    scopus 로고
    • Evaluation of histological and molecular endpoints for enhanced detection of thyroid system disruption in Xenopus laevis tadpoles
    • Opitz R., Hartmann S., Blank T., Braunbeck T., Lutz I., Kloas W. Evaluation of histological and molecular endpoints for enhanced detection of thyroid system disruption in Xenopus laevis tadpoles. Toxicol. Sci. 2006, 90:337-348.
    • (2006) Toxicol. Sci. , vol.90 , pp. 337-348
    • Opitz, R.1    Hartmann, S.2    Blank, T.3    Braunbeck, T.4    Lutz, I.5    Kloas, W.6
  • 38
    • 0029038496 scopus 로고
    • Vitellogenin induction by xenobiotic estrogens in the red-eared turtle and African clawed frog
    • Palmer B.D., Palmer S.K. Vitellogenin induction by xenobiotic estrogens in the red-eared turtle and African clawed frog. Environ. Health Perspect. 1995, 103(Suppl. 4):19-25.
    • (1995) Environ. Health Perspect. , vol.103 , Issue.SUPPL. 4 , pp. 19-25
    • Palmer, B.D.1    Palmer, S.K.2
  • 39
    • 0034894903 scopus 로고    scopus 로고
    • Masculinization of female mosquitofish in Kraft mill effluent-contaminated Fenholloway River water is associated with androgen receptor agonist activity
    • Parks L.G., Lambright C.S., Orlando E.F., Guillette L.J., Ankley G.T., Gray L.E. Masculinization of female mosquitofish in Kraft mill effluent-contaminated Fenholloway River water is associated with androgen receptor agonist activity. Toxicol. Sci. 2001, 62:257-267.
    • (2001) Toxicol. Sci. , vol.62 , pp. 257-267
    • Parks, L.G.1    Lambright, C.S.2    Orlando, E.F.3    Guillette, L.J.4    Ankley, G.T.5    Gray, L.E.6
  • 41
    • 0030066424 scopus 로고    scopus 로고
    • Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen
    • Routledge E.J., Sumpter J.P. Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen. Environ. Toxicol. Chem. 1996, 15:241-248.
    • (1996) Environ. Toxicol. Chem. , vol.15 , pp. 241-248
    • Routledge, E.J.1    Sumpter, J.P.2
  • 42
    • 4844222434 scopus 로고    scopus 로고
    • Seasonal variation in the content of hydrolyzable tannins, flavonoid glycosides, and proanthocyanidins in oak leaves
    • Salminen J.P., Roslin T., Karonen M., Sinkkonen J., Pihlaja K., Pulkkinen P. Seasonal variation in the content of hydrolyzable tannins, flavonoid glycosides, and proanthocyanidins in oak leaves. J. Chem. Ecol. 2004, 30:1693-1711.
    • (2004) J. Chem. Ecol. , vol.30 , pp. 1693-1711
    • Salminen, J.P.1    Roslin, T.2    Karonen, M.3    Sinkkonen, J.4    Pihlaja, K.5    Pulkkinen, P.6
  • 43
    • 0031656115 scopus 로고    scopus 로고
    • Several environmental oestrogens are also anti-androgens
    • Sohoni P., Sumpter J.P. Several environmental oestrogens are also anti-androgens. J. Endocrinol. 1998, 158:327-339.
    • (1998) J. Endocrinol. , vol.158 , pp. 327-339
    • Sohoni, P.1    Sumpter, J.P.2
  • 44
    • 7244242171 scopus 로고    scopus 로고
    • In vitro androgenicity in pulp and paper mill effluents
    • Svenson A., Allard A.S. In vitro androgenicity in pulp and paper mill effluents. Environ. Toxicol. 2004, 19:510-517.
    • (2004) Environ. Toxicol. , vol.19 , pp. 510-517
    • Svenson, A.1    Allard, A.S.2
  • 45
    • 33644860471 scopus 로고    scopus 로고
    • Thyroid endocrine disruption in stonerollers and cricket frogs from perchlorate-contaminated streams in east-central Texas
    • Theodorakis C.W., Rinchard J., Carr J.A., Park J.W., McDaniel L., Liu F., Wages M. Thyroid endocrine disruption in stonerollers and cricket frogs from perchlorate-contaminated streams in east-central Texas. Ecotoxicology 2006, 15:31-50.
    • (2006) Ecotoxicology , vol.15 , pp. 31-50
    • Theodorakis, C.W.1    Rinchard, J.2    Carr, J.A.3    Park, J.W.4    McDaniel, L.5    Liu, F.6    Wages, M.7
  • 46
    • 0035985134 scopus 로고    scopus 로고
    • An assessment of in vitro androgenic activity and the identification of environmental androgens in United Kingdom estuaries
    • Thomas K.V., Hurst M.R., Matthiessen P., McHugh M., Smith A., Waldock M.J. An assessment of in vitro androgenic activity and the identification of environmental androgens in United Kingdom estuaries. Environ. Toxicol. Chem. 2002, 21:1456-1461.
    • (2002) Environ. Toxicol. Chem. , vol.21 , pp. 1456-1461
    • Thomas, K.V.1    Hurst, M.R.2    Matthiessen, P.3    McHugh, M.4    Smith, A.5    Waldock, M.J.6
  • 48
    • 0042710949 scopus 로고    scopus 로고
    • Phenological variation as protection against defoliating insects: the case of Quercus robur and Operophtera brumata
    • Tikkanen O.P., Julkunen-Tiitto R. Phenological variation as protection against defoliating insects: the case of Quercus robur and Operophtera brumata. Oecologia 2003, 136:244-251.
    • (2003) Oecologia , vol.136 , pp. 244-251
    • Tikkanen, O.P.1    Julkunen-Tiitto, R.2
  • 49
    • 33644808350 scopus 로고    scopus 로고
    • Luteinizing hormone, follicle stimulating hormone, and gonadotropin releasing hormone mRNA expression of Xenopus laevis in response to endocrine disrupting compounds affecting reproductive biology
    • Urbatzka R., Lutz I., Opitz R., Kloas W. Luteinizing hormone, follicle stimulating hormone, and gonadotropin releasing hormone mRNA expression of Xenopus laevis in response to endocrine disrupting compounds affecting reproductive biology. Gen. Comp. Endocrinol. 2006, 146:119-125.
    • (2006) Gen. Comp. Endocrinol. , vol.146 , pp. 119-125
    • Urbatzka, R.1    Lutz, I.2    Opitz, R.3    Kloas, W.4
  • 50
    • 33846560990 scopus 로고    scopus 로고
    • Androgenic and antiandrogenic activities in water and sediment samples from the river Lambro, Italy, detected by yeast androgen screen and chemical analyses
    • Urbatzka R., van Cauwenberge A., Maggioni S., Vigano L., Mandich A., Benfenati E., Lutz I., Kloas W. Androgenic and antiandrogenic activities in water and sediment samples from the river Lambro, Italy, detected by yeast androgen screen and chemical analyses. Chemosphere 2007, 67:1080-1087.
    • (2007) Chemosphere , vol.67 , pp. 1080-1087
    • Urbatzka, R.1    van Cauwenberge, A.2    Maggioni, S.3    Vigano, L.4    Mandich, A.5    Benfenati, E.6    Lutz, I.7    Kloas, W.8
  • 51
    • 33846582283 scopus 로고    scopus 로고
    • Endocrine disrupters with (anti)estrogenic and (anti)androgenic modes of action affecting reproductive biology of Xenopus laevis: I. Effects on sex steroid levels and biomarker expression
    • Urbatzka R., Bottero S., Mandich A., Lutz I., Kloas W. Endocrine disrupters with (anti)estrogenic and (anti)androgenic modes of action affecting reproductive biology of Xenopus laevis: I. Effects on sex steroid levels and biomarker expression. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2007, 144:310-318.
    • (2007) Comp. Biochem. Physiol. C Toxicol. Pharmacol. , vol.144 , pp. 310-318
    • Urbatzka, R.1    Bottero, S.2    Mandich, A.3    Lutz, I.4    Kloas, W.5
  • 52
    • 48749127971 scopus 로고    scopus 로고
    • Detection of multiple hormonal activities in wastewater effluents and surface water, using a panel of steroid receptor CALUX bioassays
    • van der Linden S.C., Heringa M.B., Man H.Y., Sonneveld E., Puijker L.M., Brouwer A., Van der B.B. Detection of multiple hormonal activities in wastewater effluents and surface water, using a panel of steroid receptor CALUX bioassays. Environ. Sci. Technol. 2008, 42:5814-5820.
    • (2008) Environ. Sci. Technol. , vol.42 , pp. 5814-5820
    • van der Linden, S.C.1    Heringa, M.B.2    Man, H.Y.3    Sonneveld, E.4    Puijker, L.M.5    Brouwer, A.6    Van der, B.B.7
  • 54
    • 0025083882 scopus 로고
    • Determination of the sensitive stages for gonadal sex-reversal in Xenopus laevis tadpoles
    • Villalpando I., Merchant-Larios H. Determination of the sensitive stages for gonadal sex-reversal in Xenopus laevis tadpoles. Int. J. Dev. Biol. 1990, 34:281-285.
    • (1990) Int. J. Dev. Biol. , vol.34 , pp. 281-285
    • Villalpando, I.1    Merchant-Larios, H.2
  • 56
    • 77951297556 scopus 로고    scopus 로고
    • A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells
    • doi:10.1007/s10549-009-0547-2., in press.
    • Yao, Y., Zhou, Q., in press. A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells. Breast Cancer Res. Treat. doi: doi:10.1007/s10549-009-0547-2.
    • Breast Cancer Res. Treat.
    • Yao, Y.1    Zhou, Q.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.