Masculinization of female mosquitofish in kraft mill effluent-contaminated fenholloway river water is associated with androgen receptor agonist activity

Toxicological Sciences

Volumn 62, Issue 2, 2001, Pages 257-267

  Parks, L G ^a   Lambright, C S ^a   Orlando, E F ^b,c   Guillette Jr , L J ^b   Ankley, G T ^a   Gray Jr , L E ^a,d  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c ST MARY'S COLLEGE OF MARYLAND   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Androgen receptor; AR binding; AR gene expression; Environmental androgens; Fenholloway river; Florida; Glucocorticoid receptor; Gonopodium; In vitro; Kraft pulp and paper mill effluent; Masculinized female mosquitofish anal fin

Indexed keywords

ANDROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; HYDROXYFLUTAMIDE; INDUSTRIAL EFFLUENT; LUCIFERASE; RIVER WATER; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; CELL LINE; CELL NUCLEUS; CONTROLLED STUDY; FEMALE; FISH; GENE EXPRESSION; GENE LOCATION; GENETIC TRANSFECTION; HORMONE ACTION; IMMUNOREACTIVITY; IN VITRO STUDY; MALE; MORPHOLOGY; NONHUMAN; PULP MILL; RADIOIMMUNOASSAY; RECEPTOR AFFINITY; REPORTER GENE; RIVER; UNITED STATES; VIRILIZATION; WATER CONTAMINATION; WATER SAMPLING;

ANIMALS; COS CELLS; FEMALE; FISHES; HUMANS; IMMUNOHISTOCHEMISTRY; INDUSTRIAL WASTE; MALE; RADIOIMMUNOASSAY; RECEPTORS, ANDROGEN; SEX CHARACTERISTICS; TESTOSTERONE; TRANS-ACTIVATION (GENETICS); WATER POLLUTANTS, CHEMICAL;

ANIMALIA; GAMBUSIA AFFINIS; MOUSE MAMMARY TUMOR VIRUS;

EID: 0034894903     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/62.2.257     Document Type: Article

References (45)

1. Morphological masculinization in poeciliid females from a paper-mill effluent receiving a tributary of the St. Johns River, Florida
2. Serum levels of follicle-stimulating hormone, luteinizing hormone, prolactin, testosterone, 5 α-dihydrotestosterone, 5 α-androstane-3 α, 17 β-diol, 5 β-androstane-3 β, 17 β-diol, and 17 β-estradiol from spontaneous or induced benign prostatic hyperplasia
3. Masculinization of mosquitofish as an indicator of exposure to Kraft mill effluent
4. Microbial conversion of tall oil sterols to C-19 steroids
5. Masculinization of female mosquitofish by exposure to plant sterols and Mycobacterium smegmatis
6. Effects of Kraft Mill effluent on the sexuality of fishes: An environmental early warning?
7. Laboratory induction of intersexuality in the mosquitofish, Gambusia affinis, using paper-mill effluent
8. Testicular androgen and estrogen secretion and benign prostatic hyperplasia in the beagle
9. Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rat
10. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
11. Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida
12. Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment
13. A survey of estrogenic activity in United Kingdom inland waters
14. Masculinization of spawning channel catfish in the red river of the north
15. Abnormal expression of secondary sex characteristics in a population of mosquitofish, (Gambusia affinis holbrooki) evidence for environmentally-induced masculinization
16. Environmental formation of androgens and fish masculinization
17. Androstenedione is present in a river containing paper-mill effluent and masculinized fish
18. Identification of androstenedione in a river containing paper mill effluent
19. Vinclozolin and p,p'-DDE alter androgen-dependent gene expression: In vivo confirmation of an androgen receptor-mediated mechanism
20. A possible role for endogenous glucocorticoids in orchiectomy-induced atrophy of the rat levator ani muscle: Studies with RU 38486, a potent and selective antiglucocorticoid
21. Stimulation of androgen-dependent gene expression by the adrenal precursors dehydroepiandrosterone and androstenedione in the rat ventral prostate
22. Effects of wood-related sterols on the reproduction, egg survival, and offspring of brown trout (Salmo trutta lacustris L.)
23. Effects of the mammalian antiandrogen vinclozolin on development and reproduction of the fathead minnow (Pimephales promelas)
24. Characterization of hormone response elements
25. Diethylstilbestrol and other estrogens in the environment
26. An overview of recent studies on the potential of pulp-mill effluents to alter reproductive parameters in fish
27. Antiandrogenic effects of Di(n-Butyl) phthalate on male reproductive development: A nonreceptor-mediated mechanism
28. Effects of biologically treated elemental chlorine-free bleached Kraft-mill effluent on early life stages and life cycles of the fathead minnow (Pimephales promelas) and Ceriodaphnia dubia
29. Aromatase activity in the ovary of mosquitofish, Gambusia holbrooki, collected from the Fenholloway and Econfina Rivers, Florida
30. Macho waters: Some river pollution spawns body-altering steroids
31. Sexual dimorphism in the organization of central and peripheral mechanisms controlling sexual behavior in the mosquitofish Gambusia affinis affinis
32. Simultaneous determination of testosterone, 5α-androstan-17β-ol-3-one, 5α-androstane-3α,17β-diol and 5α-androstane-3beta,17beta-diol in plasma of adult male rabbits by radioimmunoassay(1)
33. Hormones and hormonal antagonists
34. Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays
35. An updated review of environmental estrogen and androgen mimics and antagonists
36. Male sexual development in "a sea of oestrogen"
37. Androgen receptor antagonism by the organophosphate insecticide fenitrothion
38. Comparison between the effects of the phytosterol β-sitosterol and pulp and paper mill effluents on sexually immature rainbow trout
39. Endocrine disruption in wildlife: A critical review of the evidence
40. Differential binding of endogenous steroids and chemicals to androgen receptors in rainbow trout and goldfish
41. Environmentally persistent alkylphenolic compounds are estrogenic
42. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide