Menin dynamics and functional insight: Take your partners

Molecular and Cellular Endocrinology

Volumn 326, Issue 1-2, 2010, Pages 80-84

  Balogh, Katalin ^a   Patócs, Attila ^b   Hunyady, László ^a,b   Rácz, Károly ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Cell cycle; Menin; Multiple endocrine neoplasia type 1; Tumor suppressor

Indexed keywords

BETA CATENIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN DEPENDENT KINASE; METHIONINE; MICRORNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLACTIN; PROTEIN P21; PROTEIN P27; RETINOID X RECEPTOR; SOMATOSTATIN RECEPTOR;

ARTICLE; CARCINOGENESIS; CELL CYCLE REGULATION; CELL PROLIFERATION; DNA DAMAGE; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HORMONE RELEASE; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; PARATHYROID ADENOMA; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR BINDING; RNA TRANSLATION;

CELL CYCLE; CELL NUCLEUS; HUMANS; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 77955314155     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.04.011     Document Type: Article

References (45)

1. Agarwal S.K., Guru S.C., Heppner C., Erdos M.R., Collins R.M., Park S.Y., Saggar S., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Marx S.J., Burns A.L. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 1999, 96:143-152.
2. Balogh K., Patócs A., Majnik J., Rácz K., Hunyady L. Genetic screening methods for the detection of mutations responsible for multiple endocrine neoplasia type 1. Mol. Genet. Metab. 2004, 83:74-81.
3. Balogh K., Rácz K., Patócs A., Hunyady L. Menin and its interacting proteins: elucidation of menin function. Trends Endocrinol. Metab. 2006, 17:357-364.
4. Balogh K., Hunyady L., Patocs A., Gergics P., Valkusz Z., Toth M., Racz K. MEN1 gene mutations in Hungarian patients with multiple endocrine neoplasia type 1. Clin. Endocrinol. (Oxf) 2007, 67:727-734.
5. Bertolino P., Radovanovic I., Casse H., Aguzzi A., Wang Z.Q., Zhang C.X. Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mech. Dev. 2003, 120:549-560.
6. Brandi M.L. Multiple endocrine neoplasia type 1. Rev. Endocr. Metab. Disord. 2000, 1:275-282.
7. Busygina V., Suphapeetiporn K., Marek L.R., Stowers R.S., Xu T., Bale A.E. Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. Hum. Mol. Genet. 2004, 13:2399-2408.
8. Busygina V., Kottemann M.C., Scott K.L., Plon S.E., Bale A.E. Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. Cancer Res. 2006, 66:8397-8403.
9. Canaff L.H. Menin interacts directly with the TGF beta signaling molecule Smad3 and MEN1 missense mutations within the interacting region have impaired TGF-beta transcriptional activity. Ninth International Workshop on Multiple Endocrine Neoplasia 2004, vol. 255:721-722. Blackwell Publishing, Bethesda, MD, USA.
10. Cao Y., Liu R., Jiang X., Lu J., Jiang J., Zhang C., Li X., Ning G. Nuclear-cytoplasmic shuttling of menin regulates nuclear translocation of {beta}-catenin. Mol. Cell. Biol. 2009, 29:5477-5487.
11. Chandrasekharappa S.C., Guru S.C., Manickam P., Olufemi S.E., Collins F.S., Emmert-Buck M.R., Debelenko L.V., Zhuang Z., Lubensky I.A., Liotta L.A., Crabtree J.S., Wang Y., Roe B.A., Weisemann J., Boguski M.S., Agarwal S.K., Kester M.B., Kim Y.S., Heppner C., Dong Q., Spiegel A.M., Burns A.L., Marx S.J. Positional cloning of the gene for multiple endocirne neoplasia type 1. Science 1997, 276:404-407.
12. Chen G., Goeddel D.V. TNF-R1 signaling: a beautiful pathway. Science 2002, 296:1634-1635.
13. Crabtree J.S., Scacheri P.C., Ward J.M., Garrett-Beal L., Emmert-Buck M.R., Edgemon K.A., Lorang D., Libutti S.K., Chandrasekharappa S.C., Marx S.J., Spiegel A.M., Collins F.S. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:1118-1123.
14. Dreijerink K.M., Mulder K.W., Winkler G.S., Hoppener J.W., Lips C.J., Timmers H.T. Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer Res. 2006, 66:4929-4935.
15. Dreijerink K.M., Varier R.A., van Nuland R., Broekhuizen R., Valk G.D., van der Wal J.E., Lips C.J., Kummer J.A., Timmers H.T. Regulation of vitamin D receptor function in MEN1-related parathyroid adenomas. Mol. Cell. Endocrinol. 2009, 313:1-8.
16. Dreijerink K.M., Varier R.A., van Beekum O., Jeninga E.H., Höppener J.W., Lips C.J., Kummer J.A., Kalkhoven E., Timmers H.T. The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation. Mol. Cell. Biol. 2009, 29:5060-5069.
17. Fukuuchi A., Nagamura Y., Yaguchi H., Ohkura N., Obara T., Tsukada T. A whole MEN1 gene deletion flanked by alu repeats in a family with multiple endocrine neoplasia type 1. Jpn. J. Clin. Oncol. 2006, 36:739-744.
18. Guru S.C., Goldsmith P.K., Burns A.L., Marx S.J., Spiegel A.M., Collins F.S., Chandrasekharappa S.C. Menin, the product of the MEN1 gene, is a nuclear protein. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:1630-1634.
19. Guru S.C., Prasad N.B., Shin E.J., Hemavathy K., Lu J., Ip Y.T., Agarwal S.K., Marx S.J., Spiegel A.M., Collins F.S., Oliver B., Chandrasekharappa S.C. Characterization of a MEN1 ortholog from Drosophila melanogaster. Gene 2001, 263:31-38.
20. Heppner C., Bilimoria K.Y., Agarwal S.K., Kester M., Whitty L.J., Guru S.C., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Marx S.J., Burns A.L. The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene 2001, 20:4917-4925.
21. Hughes C.M., Rozenblatt-Rosen O., Milne T.A., Copeland T.D., Levine S.S., Lee J.C., Hayes D.N., Shanmugam K.S., Bhattacharjee A., Biondi C.A., Kay G.F., Hayward N.K., Hess J.L., Meyerson M. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol. Cell 2004, 13:587-597.
22. Ikeo Y., Sakurai A., Suzuki R., Zhang M.X., Koizumi S., Takeuchi Y., Yumita W., Nakayama J., Hashizume K. Proliferation-associated expression of the MEN1 gene as revealed by in situ hybridization: possible role of the menin as a negative regulator of cell proliferation under DNA damage. Lab. Invest. 2000, 80:797-804.
23. Jin S., Mao H., Schnepp R.W., Sykes S.M., Silva A.C., D'Andrea A.D., Hua X. Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res. 2003, 63:4204-4210.
24. Karges W., Maier S., Wissmann A., Dralle H., Dosch H.M., Boehm B.O. Primary structure, gene expression and chromosomal mapping of rodent homologs of the MEN1 tumor suppressor gene. Biochim. Biophys. Acta 1999, 1446:286-294.
25. Karnik S.K., Hughes C.M., Gu X., Rozenblatt-Rosen O., McLean G.W., Xiong Y., Meyerson M., Kim S.K. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:14659-14664.
26. Karnik S.K., Chen H., McLean G.W., Heit J.J., Gu X., Zhang A.Y., Fontaine M., Yen M.H., Kim S.K. Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science 2007, 318:806-809.
27. Kim H., Lee J.E., Cho E.J., Liu J.O., Youn H.D. Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex. Cancer Res. 2003, 63:6135-6139.
28. Kottemann M.C., Bale A.E. Characterization of DNA damage-dependent cell cycle checkpoints in a menin-deficient model. DNA Repair (Amst) 2009, 6:944-952.
29. La P., Desmond A., Hou Z., Silva A.C., Schnepp R.W., Hua X. Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression. Oncogene 2006, 25:3537-3546.
30. La P., Yang Y., Karnik S.K., Silva A.C., Schnepp R.W., Kim S.K., Hua X. Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. J. Biol. Chem. 2007, 282:31332-31340.
31. Lopez-Egido J., Cunningham J., Berg M., Oberg K., Bongcam-Rudloff E., Gobl A. Menin's interaction with glial fibrillary acidic protein and vimentin suggests a role for the intermediate filament network in regulating menin activity. Exp. Cell Res. 2002, 278:175-183.
32. MacConaill L.E., Hughes C.M., Rozenblatt-Rosen O., Nannepaga S., Meyerson M. Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583. Mol. Cancer Res. 2006, 4:793-801.
33. Mensah-Osman E., Zavros Y., Merchant J.L. Somatostatin stimulates menin gene expression by inhibiting protein kinase A. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295:G843-G854.
34. Milne T.A., Dou Y., Martin M.E., Brock H.W., Roeder R.G., Hess J.L. Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:749-754.
35. Owens M., Ellard S., Vaidya B. Analysis of gross deletions in the MEN1 gene in patients with multiple endocrine neoplasia type 1. Clin. Endocrinol. (Oxf) 2008, 68:350-354.
36. Sayo Y., Murao K., Imachi H., Cao W.M., Sato M., Dobashi H., Wong N.C., Ishida T. The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells. Endocrinology 2002, 143:2437-2440.
37. Schnepp R.W., Mao H., Sykes S.M., Zong W.X., Silva A., La P., Hua X. Menin induces apoptosis in murine embryonic fibroblasts. J. Biol. Chem. 2004, 279:10685-10691.
38. Schnepp R.W., Hou Z., Wang H., Petersen C., Silva A., Masai H., Hua X. Functional interaction between tumor suppressor menin and activator of S-phase kinase. Cancer Res. 2004, 64:6791-6796.
39. Sherr C.J., Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999, 13:1501-1512.
40. Varfolomeev E.E., Schuchmann M., Luria V., Chiannilkulchai N., Beckmann J.S., Mett I.L., Rebrikov D., Brodianski V.M., Kemper O.C., Kollet O., Lapidot T., Soffer D., Sobe T., Avraham K.B., Goncharov T., Holtmann H., Lonai P., Wallach D. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 1998, 9:267-276.
41. Wermer P. Genetic aspects of adenomatosis of endocrine glands. Am. J. Med. 1954, 16:363-371.
42. Wrocklage C., Gold H., Hackl W., Buchfelder M., Fahlbusch R., Paulus W. Increased menin expression in sporadic pituitary adenomas. Clin. Endocrinol. (Oxf) 2002, 56:589-594.
43. Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D.J., Kitabayashi I., Herr W., Cleary M.L. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol. Cell. Biol. 2004, 24:5639-5649.
44. Zablewska B., Bylund L., Mandic S.A., Fromaget M., Gaudray P., Weber G. Transcription regulation of the multiple endocrine neoplasia type 1 gene in human and mouse. J. Clin. Endocrinol. Metab. 2003, 88:3845-3851.
45. Zindy P.J., L'Helgoualc'h A., Bonnier D., Le Bechec A., Bourd-Boitin K., Zhang C.X., Musso O., Glaise D., Troadec M.B., Loreal O., Turlin B., Leger J., Clement B., Theret N. Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis. Hepatology 2006, 44:1296-1307.