Effect of Emdogain on proliferation and migration of different periodontal tissue-associated cells

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

Volumn 109, Issue 6, 2010, Pages 924-931

  Qu, Zhe ^a,b   Laky, Markus ^a   Ulm, Christian ^a   Matejka, Michael ^a   Dard, Michel ^c   Andrukhov, Oleh ^a   Rausch Fan, Xiaohui ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b DALIAN UNIVERSITY   (China)

^c INSTITUT STRAUMANN AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN; SCLEROPROTEIN;

ARTICLE; CELL CULTURE; CELL MOTION; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; EPITHELIUM CELL; HUMAN; OSTEOBLAST; PERIODONTIUM;

CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DENTAL ENAMEL PROTEINS; ENDOTHELIAL CELLS; EPITHELIAL CELLS; EXTRACELLULAR MATRIX PROTEINS; HUMANS; OSTEOBLASTS; PERIODONTIUM;

EID: 77955307614     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tripleo.2010.01.007     Document Type: Article

References (32)

1. L. Hammarstrom Enamel matrix, cementum development and regeneration J Clin Periodontol 24 1997 658 668
2. E. Venezia, M. Goldstein, B.D. Boyan, and Z. Schwartz The use of enamel matrix derivative in the treatment of periodontal defects: a literature review and meta-analysis Crit Rev Oral Biol Med 15 2004 382 402
3. A. Sculean, A. Kiss, A. Miliauskaite, F. Schwarz, N.B. Arweiler, and M. Hannig Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration J Clin Periodontol 35 2008 817 824
4. U. Sakallioglu, G. Acikgoz, B. Ayas, T. Kirtiloglu, and E. Sakallioglu Healing of periodontal defects treated with enamel matrix proteins and root surface conditioningan experimental study in dogs Biomaterials 25 2004 1831 1840
5. Z. Schwartz, D.L. Carnes Jr, R. Pulliam, C.H. Lohmann, V.L. Sylvia, and Y. Liu Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells J Periodontol 71 2000 1287 1296
6. A.Z. Lee, J. Jiang, J. He, K.E. Safavi, L.S. Spangberg, and Q. Zhu Stimulation of cytokines in osteoblasts cultured on enamel matrix derivative Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106 1 2008 133 138
7. D.D. Bosshardt Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels J Clin Periodontol 35 8 Suppl 2008 87 105
8. J. Jiang, G. Goodarzi, J. He, H. Li, K.E. Safavi, and L.S. Spangberg Emdogain-gel stimulates proliferation of odontoblasts and osteoblasts Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102 2006 698 702
9. T. Nagano, T. Iwata, Y. Ogata, T. Tanabe, K. Gomi, and M. Fukae Effect of heat treatment on bioactivities of enamel matrix derivatives in human periodontal ligament (HPDL) cells J Periodontal Res 39 2004 249 256
10. X. Rausch-fan, Z. Qu, M. Wieland, M. Matejka, and A. Schedle Differentiation and cytokine synthesis of human alveolar osteoblasts compared to osteoblast-like cells (MG63) in response to titanium surfaces Dent Mater 24 2008 102 110
11. N. Pischon, B. Zimmermann, J.P. Bernimoulin, and S. Hagewald Effects of an enamel matrix derivative on human osteoblasts and PDL cells grown in organoid cultures Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102 2006 551 557
12. C. Galli, G.M. Macaluso, S. Guizzardi, R. Vescovini, M. Passeri, and G. Passeri Osteoprotegerin and receptor activator of nuclear factor-kappa B ligand modulation by enamel matrix derivative in human alveolar osteoblasts J Periodontol 77 2006 1223 1228
13. S. Mizutani, T. Tsuboi, M. Tazoe, Y. Koshihara, S. Goto, and A. Togari Involvement of FGF-2 in the action of Emdogain on normal human osteoblastic activity Oral Dis 9 2003 210 217
14. M.O. Klein, C. Reichert, D. Koch, S. Horn, and B. Al-Nawas In vitro assessment of motility and proliferation of human osteogenic cells on different isolated extracellular matrix components compared with enamel matrix derivative by continuous single-cell observation Clin Oral Implants Res 18 2007 40 45
15. T. Kawase, K. Okuda, H. Yoshie, and D.M. Burns Cytostatic action of enamel matrix derivative (EMDOGAIN) on human oral squamous cell carcinoma-derived SCC25 epithelial cells J Periodontal Res 35 2000 291 300
16. Y. Kawashima, and I. Ishikawa Simple and rapid detection of serum antibody to periodontopathic bacteria by dot blotting J Periodontal Res 37 2002 223 229
17. S.P. Lyngstadaas, E. Lundberg, H. Ekdahl, C. Andersson, and S. Gestrelius Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative J Clin Periodontol 28 2001 181 188
18. J.C. Rincon, Y. Xiao, W.G. Young, and P.M. Bartold Enhanced proliferation, attachment and osteopontin expression by porcine periodontal cells exposed to Emdogain Arch Oral Biol 50 2005 1047 1054
19. K. Bertl, N. An, C. Bruckmann, M. Dard, O. Andrukhov, and M. Matejka Effects of enamel matrix derivative on proliferation/viability, migration, and expression of angiogenic factor and adhesion molecules in endothelial cells in vitro J Periodontol 80 2009 1622 1630
20. K. Yuan, C.L. Chen, and M.T. Lin Enamel matrix derivative exhibits angiogenic effect in vitro and in a murine model J Clin Periodontol 30 2003 732 738
21. S.R. Schlueter, D.L. Carnes, and D.L. Cochran In vitro effects of enamel matrix derivative on microvascular cells J Periodontol 78 2007 141 151
22. M.S. Tonetti, I. Fourmousis, J. Suvan, P. Cortellini, U. Bragger, and N.P. Lang Healing, post-operative morbidity and patient perception of outcomes following regenerative therapy of deep intrabony defects J Clin Periodontol 31 2004 1092 1098
23. R.A. Yukna, and J.T. Mellonig Histologic evaluation of periodontal healing in humans following regenerative therapy with enamel matrix derivative A 10-case series J Periodontol 71 2000 752 759
24. T. Kawase, K. Okuda, H. Yoshie, and D.M. Burns Anti-TGF-beta antibody blocks enamel matrix derivative-induced upregulation of p21WAF1/cip1 and prevents its inhibition of human oral epithelial cell proliferation J Periodontal Res 37 2002 255 262
25. T. Kawase, K. Okuda, M. Momose, Y. Kato, H. Yoshie, and D.M. Burns Enamel matrix derivative (EMDOGAIN) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells J Periodontal Res 36 2001 367 376
26. L. Hammarstrom, L. Heijl, and S. Gestrelius Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins J Clin Periodontol 24 1997 669 677
27. Y. Koike, S. Murakami, K. Matsuzaka, and T. Inoue The effect of Emdogain on ectopic bone formation in tubes of rat demineralized dentin matrix J Periodontal Res 40 2005 385 394
28. D.L. Johnson, D. Carnes, B. Steffensen, and D.L. Cochran Cellular effects of enamel matrix derivative are associated with different molecular weight fractions following separation by size-exclusion chromatography J Periodontol 80 2009 648 656
29. A.M. Hoang, R.J. Klebe, B. Steffensen, O.H. Ryu, J.P. Simmer, and D.L. Cochran Amelogenin is a cell adhesion protein J Dent Res 81 2002 497 500
30. J. Maycock, S.R. Wood, S.J. Brookes, R.C. Shore, C. Robinson, and J. Kirkham Characterization of a porcine amelogenin preparation, EMDOGAIN, a biological treatment for periodontal disease Connect Tissue Res 43 2002 472 476
31. A. Mumulidu, B. Hildebrand, B. Fabi, L. Hammarstrom, D.L. Cochran, and M. Dard Purification and analysis of a 5kDa component of enamel matrix derivative J Chromatogr 857 2007 210 218
32. A. Veis Amelogenin gene splice products: potential signaling molecules Cell Mol Life Sci 60 2003 38 55