No association between Oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences

PLoS ONE

Volumn 5, Issue 6, 2010, Pages

  Apicella, Coren L ^a,b   Cesarini, David ^c   Johannesson, Magnus ^d   Dawes, Christopher T ^e   Lichtenstein, Paul ^f   Wallace, Björn ^d   Beauchamp, Jonathan ^b   Westberg, Lars ^g  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d STOCKHOLM SCHOOL OF ECONOMICS   (Sweden)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f KAROLINSKA INSTITUTE   (Sweden)

^g UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

OXYTOCIN RECEPTOR;

ARTICLE; AUTHORITY; CONTROLLED STUDY; ECONOMIC BEHAVIOR; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; PHENOTYPIC VARIATION; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL BEHAVIOR; SOCIAL PREFERENCE; SWEDEN; TRUST; TWINS; ECONOMICS; GENETICS;

ECONOMICS; FEMALE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OXYTOCIN; SOCIAL BEHAVIOR;

EID: 77955296986     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011153     Document Type: Article

References (49)

1. Camerer CF (2003) Behavioral Game Theory: Experiments in Strategic Interaction. Princeton: Princeton Univ Press. 544 p.
2. Charness G, Rabin M (2002) Understanding Social Preferences with Simple Tests. Q J Econ 117: 817-869.
3. Fehr E, Fischbacher U (2002) Why social preferences matter - the impact of non-selfish motives on competition, cooperation and incentives. Econ J 112: C1-C33.
4. Gintis HS, Bowles S, Boyd R, Fehr E (2003) Explaining Altruistic Behavior in Humans. Evol Hum Behav 24: 153-172.
5. Henrich J, Boyd R, Bowles S, Camerer C, Fehr E, et al. (2004) Foundations of Human Sociality: Economic Implications and Ethnographic Evidence from Fifteen Small-Scale Societies. New York: Oxford University Press. 451 p.
6. Fischbacher U, Gächter S (2008) Heterogeneous Social Preferences and the Dynamics of Free Riding in Public Goods. CeDEx Discussion Paper No. 2008-07.
7. Kurzban R, Houser D (2005) Experiments investigating cooperative types in humans: A complement to evolutionary theory and simulations. Proc Natl Acad Sci USA 102: 1803-1807.
8. Benjamin DJ, Chabris CF, Glaeser EL, Gudnason V, Harris TB, et al. (2007) Genoeconomics. In Weinstein M, Vaupel JW, Wachter KW, eds. Biosocial Surveys. Washington, D.C.: The National Academies Press. pp 304-335.
9. Donaldson ZR, Young LJ (2008) Oxytocin, Vasopressin, and the Neurogenetics of Sociality. Science 322: 900-904.
10. Lee HJ, Macbeth AH, Pagani JH, Young SW (2009) Oxytocin: The great facilitator of life. Prog Neurobiol 88: 127-151.
11. Ross HE, Young LJ (2009) Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. Front Neuroendocrinol 30: 534-47.
12. Zak PJ, Kurzban R, Matzner WT (2005) Oxytocin is associated with human trustworthiness. Horm Behav 48: 522-527.
13. Berg JE, Dickhaut J, McCabe K (1995) Trust, reciprocity, and social history. Game Econ Behav 10: 122-142.
14. Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E (2005) Oxytocin increases trust in humans. Nature 435: 673-676.
15. Zak PJ, Stanton AA, Ahmadi S (2007) Oxytocin increases generosity in humans. PloS One 2(11): e1128.
16. Ditzen B, Schaer M, Gabriel B, Bodenmann G, Ehlert U, et al. (2009) Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biol Psychiat 65: 728-731.
17. Cesarini D, Dawes CT, Fowler JH, Johannesson M, Lichtenstein P, et al. (2008) Heritability of cooperative behavior in the trust game. Proc Natl Acad Sci USA 105: 3721-3726.
18. Cesarini D, Dawes CT, Johannesson M, Lichtenstein P, Wallace B (2009) Genetic Variation in Preferences for Giving and Risk Taking. Q J Econ 124: 809-842.
19. Inoue T, Kimura T, Azuma C, Inazawa J, Takemura M, et al. (1994) Structural organization of the human oxytocin receptor gene. J Biol Chem 269: 32451-32456.
20. Lauritsen MB, Als TD, Dahl HA, Flint TJ, Wang AG, et al. (2006) A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands. Mol Psychiatr 11: 37-46.
21. McCauley JL, Li C, Jiang L, Olson LM, Crockett G, et al. (2005) Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates. BMC Med Genet 6: 1.
22. Ylisaukko-oja T, Alarcó M, Cantor RM, Auranen M, Vanhala R, et al. (2006) Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families. Ann Neurol 59: 145-55.
23. Wu S, Jia M, Ruan Y, Liu J, Guo Y, et al. (2005) Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol Psychiat 58: 74-77.
24. Lerer E, Levi S, Salomon S, Darvasi A, Yirmiya N, et al. (2008) Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. Mol Psychiat 13: 980-988.
25. Tansey KE, Brookes KJ, Hill MJ, Cochrane LE, Gill M, et al. (2010) Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: Genetic and molecular studies. Neurosci Lett, In press.
26. Yrigollen CM, Han SS, Kochetkova A, Babitz T, Chang JT, et al. (2008) Genes Controlling Affiliative Behavior as Candidate Genes for Autism. Biol Psychiat 63: 911-916.
27. Rodrigues SM, Saslow LR, Garcia N, John OP, Keltner D (2009) Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci USA 106: 21437-21441.
28. Israel S, Lerer E, Shalev I, Uzefovsky F, Riebold M, et al. (2009) The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. PLoS One 4: e5535.
29. Costa B, Pini S, Gabelloni P, Abelli M, Lari L, et al. (2009) Oxytocin receptor polymorphism and adult attachment style in patients with depression. Psychoneuroendocrino 34: 1506-1514.
30. Bakermans-Kranenburg MJ, van Ijzendoorn MH (2008) Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Soc Cog Affect Neurosci 3: 128-134.
31. Wang K, Zhang H, Ma D, Bucan M, Glessner JT, et al. (2009) Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature 459: 528-533.
32. Takayanagi Y, Yoshida M, Bielsky IF, Ross HE, Kawamata M, et al. (2005) Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc Natl Acad Sci USA 102: 16096-16101.
33. Winslow JT, Insel TR (2002) The social deficits of the oxytocin knockout mouse. Neuropeptides 36: 221-229.
34. Hertwig R, Ortmann A (2001) Experimental practices in economics: A methodological challenge for psychologists. Behav Brain Sci 24: 383-403.
35. Cleves M (1999) Hardy-Weinberg equilibrium test and allele frequency estimation. Stata Tech Bull 48: 34-37.
36. Suma J, Brune CW, Carter CS, Leventhal BL, Lord C, et al. (2007) Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neurosci Lett 417: 6-9.
37. Forsythe R, Horowitz JL, Savin NE, Sefton M (1994) Fairness in Simple Bargaining Experiments. Game Econ Behav 6: 347-369.
38. Eckel CC, Grossman PJ (1996) Altruism in Anonymous Dictator Games. Game Econ Behav 16: 181-191.
39. Neale BM, Ferreira MAR, Medland SE, Posthuma D, eds. (2007) Statistical Genetics. London: Taylor and Francis. 608 p.
40. Bales KL, Pfeifer LA, Carter CS (2004) Sex differences and developmental effects of manipulations of oxytocin on alloparenting and anxiety in prairie voles. Dev Psychobiol 44: 123-131.
41. Domes G, Lischke A, Berger C, Grossmann A, Hauenstein K, et al. (2009) Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinol 35: 83-93.
42. Ioannidis JPA, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG (2001) Replication validity of genetic association studies. Nat Genet 29: 306-309.
43. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K (2002) A comprehensive review of genetic association studies. Genet Med 4: 45-61.
44. Ioannidis JPA (2005) Why Most Published Research Findings are False. PLoS Medicine 2: e124.
45. Wermter AK, Kamp-Becker I, Hesse P, Schulte-Körne G, Strauch K, et al. (2010) Evidence for the involvement of genetic variation in the oxyto cin receptorgene (OXTR) in the etiology of autistic disorders on high-functioning level. Am J Med Genet B Neuropsychiatr Genet 5: 629-39.
46. Zöllner S, Pritchard JK (2007) Overcoming the winner's curse: estimating penetrance parameters from case-control data. Am J Hum Genet 80: 605-615.
47. Ioannidis JPA, Patsopoulos NA, Evangelou E (2007) Heterogeneity in metaanalyses of genome-wide association investigations. PLoS ONE 2(9): e841.
48. Ioannidis JPA, Trikalinos TA, Ntzani EE, Contopoulos-Ioannidis DG (2003) Genetic associations in large versus small studies: an empirical assessment. Lancet 361: 567-571.
49. Ioannidis JPA (2007) Non-replication and inconsistency in the genome-wide association setting. Hum Hered 64: 203-213.