Phosphorylation states of STAT3 and ERKs in mouse embryonic stem cells

Cell Biology International

Volumn 34, Issue 5, 2010, Pages 485-492

  Miyazu, Sakiko ^a   Furuno, Tadahide ^a,b   Nakanishi, Mamoru ^a,b  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Embryonic stem cell; ERKs; Leukaemia inhibitory factor; MAP kinase cascade; SOCS3; STAT3

Indexed keywords

LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; ENZYME INHIBITOR; FLAVONOID; SOCS3 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVATION; MOUSE; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CYTOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; CELL LINE; EMBRYONIC STEM CELLS; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; LEUKEMIA INHIBITORY FACTOR; MICE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 77955283815     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20090466     Document Type: Article

References (45)

1. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995;270:27489-94.
2. Amano K, Furuno T, Nakanishi M. Conditioned medium from feeder STO cells increases the attachment of mouse embryonic stem cells. Biol Pharm Bull 2006;29:1747-50.
3. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I et al. Regulation of gliogenesis in the central nervous system by the JAKSTAT signaling pathway. Science 1997;278:477-83.
4. Bousquet C, Susini C, Melmed S. Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor. J Clin Invest 1999;104:1277-85.
5. Burdon T, Stracey C, Chambers I, Nichols J, Smith A. Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol 1999a;210:30-43.
6. Burdon T, Chambers I, Stracey C, Niwa H, Smith A. Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells. Cells Tissues Organs 1999b;165:131-43.
7. Burdon T, Smith A, Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 2002;12:432-8.
8. Chan RJ, Johnson SA, Li Y, Yoder MC, Feng GS. A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood 2003;102:2074-80.
9. Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008;133:1106-17.
10. Darnell JE, Jr. STATs and gene regulation. Science 1997;277:1630-5.
11. Duval D, Reinhardt B, Kedinger C, Boeuf H. Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF)-dependent embryonic stem cell survival. FASEB J 2000;14: 1577-84.
12. Ernst M, Oates A, Dunn AR. gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogenactivated protein kinase pathways. J Biol Chem 271;1996: 30136-43.
13. Ernst M, Jenkins BJ. Acquiring signaling specificity from the cytokine receptor gp130. Trends Genet 2004;20:23-32.
14. Forrai A, Boyle K, Hart AH, Hartley L, Rakar S, Willson TA et al. Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells. Stem Cells 2006;24:604-14.
15. Fukada T, Hibi M, Yamanaka Y, Takahashi-Tezuka M, Fujitani Y, Yamaguchi T et al. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 1996;5:449-60.
16. Furuno T, Hirashima N, Onizawa S, Sagiya N, Nakanishi M. Nuclear shuttling of mitogen-activated protein (MAP) kinase (extracellular signal-regulated kinase (ERK) 2) was dynamically controlled by MAP/ERK kinase after antigen stimulation in RBL-2H3 cells. J Immunol 2001;166:4416-21.
17. Furuno T, Ito A, Koma Y, Watabe K, Yokozaki H, Bienenstock J et al. The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. J Immunol 2005;174:6934-42.
18. Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 1998;334:297-314.
19. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003;374:1-20.
20. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990;63:1149-57.
21. Ihara S, Nakajima K, Fukada T, Hibi M, Nagata S, Hirano T et al. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. EMBO J 1997;16:5345-52.
22. Jirmanova L, Afanassieff M, Gobert-Gosse S, Markossian S, Savatier P. Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells. Oncogene 2002;21:5515-28.
23. Kristensen DM, Kalisz M, Nielsen JH. Cytokine signalling in embryonic stem cells. APMIS 2005;113:756-72.
24. Li J, Wang G, Wang C, Zhao Y, Zhang H, Tan Z et al. MEK/ERK signaling contributes to the maintenance of human embryonic stem cell selfrenewal. Differentiation 2007;75:299-307.
25. Matsuda T, Nakamura T, Nakao K, Arai T, Katsuki M, Heike T et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J 1999;18:4261-9.
26. Nicholson SE, De Souza D, Fabri LJ, Corbin J, Willson TA, Zhang JG et al. Suppressor of cytokine signalling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci USA 2000;97:6493-8.
27. Niwa H, Burdon T, Chambers I, Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 1998;12:2048-60.
28. Okita K, Yamanaka S. Intracellular signaling pathways regulating pluripotency of embryonic stem cells. Curr Stem Cell Res Ther 2006;1:103-11.
29. Qu CK, Shi ZQ, Shen R, Tsai FY, Orkin SH, Feng GS. A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol 1997;17:5499-507.
30. Raz R, Lee CK, Cannizzaro LA, d'Eustachio P, Levy DE. Essential role of STAT3 for embryonic stem cell pluripotency. Proc Natl Acad Sci USA 1999;96:2846-51.
31. Schindler C, Darnell JE, Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem1995;64:621-51.
32. Schmitz J, Weissenbach M, Haan S, Heinrich PC, Schaper F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem 2000;275:12848-56.
33. Sengupta TK, Talbot ES, Scherle PA, Ivashkiv LB. Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogenactivated protein kinases. Proc Natl Acad Sci USA 1998;95: 11107-12.
34. Smith AG, Heath JK, Donaldson DD, Wong GG, Moreau J, Stahl M et al. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 1988;336:688-90.
35. Stahl N, Boulton TG, Farruggella T, Ip NY, Davis S, Witthuhn BA et al. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM- IL-6β receptor components. Science 1994;263:92-5.
36. Sugimoto Y, Furuno T, Nakanishi M. Effect of NeuroD2 expression on neuronal differentiation in mouse embryonic stem cells. Cell Biol Int 2009;33:174-9.
37. Suzuki A, Suzuki R, Furuno T, Teshima R, Nakanishi M. N-cadherin plays a role in the synapse-like structures between mast cells and neurites. Biol Pharm Bull 2004;27:1891-4.
38. Torres J, Watt FM. Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkB and cooperating with Stat3. Nat Cell Biol 2008;10:194-201.
39. Turkson J, Kim JS, Zhang S, Yuan J, Huang M, Glenn M et al. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol Cancer Ther 2004;3:261-9.
40. Van Vactor D, O'Reilly AM, Neel BG. Genetic analysis of protein tyrosine phosphatases. Curr Opin Genet Dev 1998;8:112-26.
41. Williams RL, Hilton DJ, Pease S, Willson TA, Stewart CL, Gearing DP et al. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 1988;336:684-7.
42. Wobus AM, Boheler KR. Embryonic stem cells: prospects for developmental biology and cell therapy. Physiol Rev 2005;85:635- 78.
43. Yao Y, Li W, Wu J, Germann UA, Su MSS, Kuida K et al. Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc Natl Acad Sci USA 2003;100:12759-64.
44. Ying QL, Nichols J, Chambers I, Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell selfrenewal in collaboration with STAT3. Cell 2003;115:281-92.
45. Ying QL, Wray J, Nichols J, Batlle-Morera L, Doble B, Woodgett J et al. The ground state of embryonic stem cell self-renewal. Nature 2008;453:519-23.