NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids

Atherosclerosis

Volumn 211, Issue 2, 2010, Pages 539-544

  Ferguson, Jane F ^a   Phillips, Catherine M ^a   McMonagle, Jolene ^a   Pérez Martínez, Pablo ^b   Shaw, Danielle I ^d   Lovegrove, Julie A ^d   Helal, Olfa ^c   Defoort, Catherine ^e   Gjelstad, Ingrid M F ^e,f   Drevon, Christian A ^c   Blaak, Ellen E ^g   Saris, Wim H M ^g   Leszczyńska Gołaogonekbek, Iwona ^h   Kiec Wilk, Beata ^h   Risérus, Ulf ⁱ   Karlström, Brita ⁱ   Lopez Miranda, Jose ^b   Roche, Helen M ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^c INSERM   (France)

^d UNIVERSITY OF READING   (United Kingdom)

^e UNIVERSITY OF OSLO   (Norway)

^f AKER UNIVERSITY HOSPITAL   (Norway)

^g MAASTRICHT UNIVERSITY   (Netherlands)

^h JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

ⁱ UPPSALA UNIVERSITY   (Sweden)

Author keywords

CVD; Gene nutrient interaction; N 3 PUFA; NOS3; SNP association; TAG

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; LONG CHAIN FATTY ACID; OMEGA 3 FATTY ACID; TRIACYLGLYCEROL;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIETARY INTAKE; DNA POLYMORPHISM; DYSLIPIDEMIA; FATTY ACID BLOOD LEVEL; FEMALE; GENE INTERACTION; GENE NUTRIENT INTERACTION; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INFLAMMATION; LIPID COMPOSITION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; DYSLIPIDEMIAS; FATTY ACIDS, OMEGA-3; FATTY ACIDS, UNSATURATED; FEMALE; GENOTYPE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC; RISK; RISK FACTORS; TRIGLYCERIDES;

EID: 77955278690     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.03.027     Document Type: Article

References (30)

1. Lloyd-Jones D., Adams R., Carnethon M., et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009, 119(3):480-486.
2. Qiao Q. Comparison of different definitions of the metabolic syndrome in relation to cardiovascular mortality in European men and women. Diabetologia 2006, 49(12):2837-2846.
3. Moller D.E., Kaufman K.D. Metabolic syndrome: a clinical and molecular perspective. Annu Rev Med 2005, 56:45-62.
4. Roche H.M., Phillips C., Gibney M.J. The metabolic syndrome: the crossroads of diet and genetics. Proc Nutr Soc 2005, 64(3):371-377.
5. Psota T.L., Gebauer S.K., Kris-Etherton P. Dietary omega-3 fatty acid intake and cardiovascular risk. Am J Cardiol 2006, 98(4A):3i-18i.
6. Hooper L., Thompson R.L., Harrison R.A., et al. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev 2004, (4):CD003177.
7. Pieper G.M. Enhanced, unaltered and impaired nitric oxide-mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia 1999, 42(2):204-213.
8. Hooper W.C. The relationship between inflammation and the anticoagulant pathway: the emerging role of endothelial nitric oxide synthase (eNOS). Curr Pharm Des 2004, 10(8):923-927.
9. Higaki Y., Hirshman M.F., Fujii N., et al. Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle. Diabetes 2001, 50(2):241-247.
10. Chrysohoou C., Panagiotakos D.B., Pitsavos C., et al. Evidence for association between endothelial nitric oxide synthase gene polymorphism (G894T) and inflammatory markers: the ATTICA study. Am Heart J 2004, 148(4):733-738.
11. Monti L.D., Barlassina C., Citterio L., et al. Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome. Diabetes 2003, 52(5):1270-1275.
12. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Jama 2001; 285(19):2486-97.
13. Shaw D.I., Tierney A.C., McCarthy S., et al. LIPGENE food-exchange model for alteration of dietary fat quantity and quality in free-living participants from eight European countries. Br J Nutr 2008, 1-10.
14. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28(7):412-419.
15. Phillips C.M., Goumidi L., Bertrais S., et al. Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome. Am J Clin Nutr 2009.
16. Tregouet D.A., Garelle V. A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies. Bioinformatics 2007, 23(8):1038-1039.
17. Hu C.J., Wang C.H., Lee J.H., et al. Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area. Clin Chem Lab Med 2007, 45(1):20-25.
18. Thameem F., Puppala S., Arar N.H., et al. Endothelial nitric oxide synthase (eNOS) gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans. Diab Vasc Dis Res 2008, 5(2):109-113.
19. Pereira T.V., Rudnicki M., Cheung B.M., et al. Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias. J Hypertens 2007, 25(9):1763-1774.
20. Metzger I.F., Sertorio J.T., Tanus-Santos J.E. Modulation of nitric oxide formation by endothelial nitric oxide synthase gene haplotypes. Free Radic Biol Med 2007, 43(6):987-992.
21. Austin M.A. Triacylglycerol and coronary heart disease. Proc Nutr Soc 1997, 56(2):667-670.
22. Khedara A., Kawai Y., Kayashita J., et al. Feeding rats the nitric oxide synthase inhibitor. L-N(omega)nitroarginine, elevates serum triglyceride and cholesterol and lowers hepatic fatty acid oxidation. J Nutr 1996, 126(10):2563-2567.
23. McVeigh G.E., Brennan G.M., Johnston G.D., et al. Dietary fish oil augments nitric oxide production or release in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1993, 36(1):33-38.
24. Piolot A., Blache D., Boulet L., et al. Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health. J Lab Clin Med 2003, 141(1):41-49.
25. Mori T.A., Watts G.F., Burke V., et al. Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. Circulation 2000, 102(11):1264-1269.
26. Lopez D., Orta X., Casos K., et al. Upregulation of endothelial nitric oxide synthase in rat aorta after ingestion of fish oil-rich diet. Am J Physiol Heart Circ Physiol 2004, 287(2):H567-H572.
27. Li Q., Zhang Q., Wang M., et al. Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae. Arch Biochem Biophys 2007, 466(2):250-259.
28. Li Q., Zhang Q., Wang M., et al. Eicosapentaenoic acid modifies lipid composition in caveolae and induces translocation of endothelial nitric oxide synthase. Biochimie 2007, 89(1):169-177.
29. Ortegren U., Aboulaich N., Ost A., et al. A new role for caveolae as metabolic platforms. Trends Endocrinol Metab 2007, 18(9):344-349.
30. Joshi M.S., Mineo C., Shaul P.W., et al. Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: altered caveolar localization and impaired response to shear. FASEB J 2007, 21(11):2655-2663.