Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors

FEBS Letters

Volumn 584, Issue 15, 2010, Pages 3446-3451

  Tholander, Fredrik ^a   Roques, Bernard Pierre ^c   Fournié Zaluski, Marie Claude ^d   Thunnissen, Marjolein M G M ^b   Haeggström, Jesper Z ^a,e  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c Laboratoire de Pharmacochimie   (France)

^d Pharmaleads   (France)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Aminopeptidase; Cardiovascular; Inflammation; Leukotriene

Indexed keywords

KELATORPHAN; LEUKOTRIENE A4 HYDROLASE; METALLOPROTEINASE INHIBITOR; MICROSOMAL AMINOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE 1; UNCLASSIFIED DRUG; ZINC METALLOPROTEINASE INHIBITOR;

ARTICLE; BINDING SITE; CHELATION; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

MAMMALIA;

EID: 77955273560     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.06.044     Document Type: Article

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