Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species

Toxicology and Applied Pharmacology

Volumn 247, Issue 2, 2010, Pages 76-82

  Gray, Joshua P ^a,b   Mishin, Vladimir ^b   Heck, Diane E ^c   Laskin, Debra L ^b   Laskin, Jeffrey D ^d  

^a U S COAST GUARD ACADEMY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

CEES; Oxidative stress; Pulmonary toxicity; Sulfur mustard; Vesicants

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME C; CYTOCHROME P450; CYTOCHROME P450 1A1; MUSTARD GAS; REACTIVE OXYGEN METABOLITE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; SODIUM CHLORIDE; SULFUR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRASSICA; CLARA CELL; DETOXIFICATION; ELECTRON; ENZYME INHIBITION; EPITHELIUM CELL; LIVER MICROSOME; LUNG ALVEOLUS CELL; LUNG INJURY; METABOLITE; MICROSOME; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RAT; UPPER RESPIRATORY TRACT;

RATTUS;

EID: 77955272131     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.05.015     Document Type: Article

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