Unique biomechanical interactions between myeloma cells and bone marrow stroma cells

Progress in Biophysics and Molecular Biology

Volumn 103, Issue 1, 2010, Pages 148-156

  Feng, Yongdong ^a,b   Ofek, Gidon ^c   Choi, Dong Soon ^a   Wen, Jianguo ^a   Hu, Jerry ^d   Zhao, Hong ^a   Zu, Youli ^a,e   Athanasiou, Kyriacos A ^d   Chang, Chung Che ^a,e  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Rice University   (United States)

^d University of California Davis   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Bone marrow stroma cell; Myeloma; Niche; Stiffness

Indexed keywords

EID: 77955271793     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbiomolbio.2009.10.004     Document Type: Review

References (36)

1. Anderson K.C. Targeted therapy of multiple myeloma based upon tumor-microenvironmental interactions. Exp. Hematol. 2007, 35:155-162.
2. Assoian R.K., Klein E.A. Growth control by intracellular tension and extracellular stiffness. Trends Cell Biol. 2008, 18:347-352.
3. Basak G.W., Srivastava A.S., Malhotra R., Carrier E. Multiple myeloma bone marrow niche. Curr. Pharm. Biotechnol. 2009, 10:345-346.
4. Burridge K., Wennerberg K. Rho and Rac take center stage. Cell 2004, 116:167-179.
5. Butcher D.T., Alliston T., Weaver V.M. A tense situation: forcing tumour progression. Nat. Rev. Cancer 2009, 9:108-122.
6. Byfield F.J., Reen R.K., Shentu T.P., Levitan I., Gooch K.J. Endothelial actin and cell stiffness is modulated by substrate stiffness in 2D and 3D. J. Biomech. 2009, 42:1114-1119.
7. Chatterjee M., Stuhmer T., Herrmann P., Bommert K., Dorken B., Bargou R.C. Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells. Blood 2004, 104:3712-3721.
8. Cross S.E., Jin Y.S., Rao J., Gimzewski J.K. Nanomechanical analysis of cells from cancer patients. Nat. Nanotechnol 2007, 2:780-783.
9. Dai Y., Chen S., Pei X.Y., Almenara J.A., Kramer L.B., Venditti C.A., Dent P., Grant S. Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells. Blood 2008, 112:2439-2449.
10. Darling E.M., Zauscher S., Block J.A., Guilak F. A thin-layer model for viscoelastic, stress-relaxation testing of cells using atomic force microscopy: do cell properties reflect metastatic potential?. Biophys. J. 2007, 92:1784-1791.
11. De Raeve H.R., Vanderkerken K. The role of the bone marrow microenvironment in multiple myeloma. Histol. Histopathol 2005, 20:1227-1250.
12. Discher D.E., Janmey P., Wang Y.L. Tissue cells feel and respond to the stiffness of their substrate. Science 2005, 310:1139-1143.
13. Garderet L., Mazurier C., Chapel A., Ernou I., Boutin L., Holy X., Gorin N.C., Lopez M., Doucet C., Lataillade J.J. Mesenchymal stem cell abnormalities in patients with multiple myeloma. Leuk. Lymphoma 2007, 48:2032-2041.
14. Goodell M.A., McKinney-Freeman S., Camargo F.D. Isolation and characterization of side population cells. Methods Mol. Biol. 2005, 290:343-352.
15. Hamada H., Kobune M., Nakamura K., Kawano Y., Kato K., Honmou O., Houkin K., Matsunaga T., Niitsu Y. Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy. Cancer Sci. 2005, 96:149-156.
16. Hideshima T., Mitsiades C., Tonon G., Richardson P.G., Anderson K.C. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat. Rev. Cancer 2007, 7:585-598.
17. Hirschmann-Jax C., Foster A.E., Wulf G.G., Goodell M.A., Brenner M.K. A distinct "side population" of cells in human tumor cells: implications for tumor biology and therapy. Cell Cycle 2005, 4:203-205.
18. Huang S., Ingber D.E. Cell tension, matrix mechanics, and cancer development. Cancer Cell 2005, 8:175-176.
19. Ingber D.E., Madri J.A., Jamieson J.D. Role of basal lamina in neoplastic disorganization of tissue architecture. Proc. Natl. Acad. Sci. U S A 1981, 78:3901-3905.
20. Koay E.J., Ofek G., Athanasiou K.A. Effects of TGF-beta1 and IGF-I on the compressibility, biomechanics, and strain-dependent recovery behavior of single chondrocytes. J. Biomech. 2008, 41:1044-1052.
21. Li C., Wong W.H. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. U S A 2001, 98:31-36.
22. Matsui W., Huff C.A., Wang Q., Malehorn M.T., Barber J., Tanhehco Y., Smith B.D., Civin C.I., Jones R.J. Characterization of clonogenic multiple myeloma cells. Blood 2004, 103:2332-2336.
23. Matsui W., Wang Q., Barber J.P., Brennan S., Smith B.D., Borrello I., McNiece I., Lin L., Ambinder R.F., Peacock C., Watkins D.N., Huff C.A., Jones R.J. Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. Cancer Res. 2008, 68:190-197.
24. Mitsiades C.S., McMillin D.W., Klippel S., Hideshima T., Chauhan D., Richardson P.G., Munshi N.C., Anderson K.C. The role of the bone marrow microenvironment in the pathophysiology of myeloma and its significance in the development of more effective therapies. Hematol. Oncol. Clin. North Am. 2007, 21:1007-1034. (vii-viii).
25. Mitsiades C.S., Mitsiades N.S., Munshi N.C., Richardson P.G., Anderson K.C. The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions. Eur. J. Cancer 2006, 42:1564-1573.
26. Mitsiades C.S., Mitsiades N.S., Richardson P.G., Munshi N.C., Anderson K.C. Multiple myeloma: a prototypic disease model for the characterization and therapeutic targeting of interactions between tumor cells and their local microenvironment. J. Cell Biochem. 2007, 101:950-968.
27. Ofek G., Willard V.P., Koay E.J., Hu J.C., Lin P., Athanasiou K.A. Mechanical characterization of differentiated human embryonic stem cells. J. Biomech. Eng. 2009, 131:061011.
28. Park D.W., Ryu H.S., Choi D.S., Park Y.H., Chang K.H., Min C.K. Localization of matrix metalloproteinases on endometrial cancer cell invasion in vitro. Gynecol. Oncol. 2001, 82:442-449.
29. Podar K., Richardson P.G., Hideshima T., Chauhan D., Anderson K.C. The malignant clone and the bone-marrow environment. Best Pract. Res. Clin. Haematol. 2007, 20:597-612.
30. Roovers K., Assoian R.K. Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases. Mol. Cell Biol. 2003, 23:4283-4294.
31. Shieh A.C., Koay E.J., Athanasiou K.A. Strain-dependent recovery behavior of single chondrocytes. Biomech. Model. Mechanobiol 2006, 5:172-179.
32. Tilghman R.W., Parsons J.T. Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin. Cancer Biol. 2008, 18:45-52.
33. Van Citters K.M., Hoffman B.D., Massiera G., Crocker J.C. The role of F-actin and myosin in epithelial cell rheology. Biophys. J. 2006, 91:3946-3956.
34. Wang X.Q., Lindberg F.P., Frazier W.A. Integrin-associated protein stimulates alpha2beta1-dependent chemotaxis via Gi-mediated inhibition of adenylate cyclase and extracellular-regulated kinases. J. Cell Biol. 1999, 147:389-400.
35. Wen J., Feng Y., Huang W., Chen H., Liao B., Rice L., Preti H.A., Kamble R.T., Zu Y., Ballon D.J., Chang C.C. Enhanced antimyeloma cytotoxicity by the combination of arsenic trioxide and bortezomib is further potentiated by p38 MAPK inhibition. Leuk. Res 2009.
36. Wozniak M.A., Desai R., Solski P.A., Der C.J., Keely P.J. ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J. Cell Biol. 2003, 163:583-595.