Acyclic retinoid NIK-333 accelerates liver regeneration and lowers serum transaminase activities in 70% partially hepatectomized rats, in vivo

European Journal of Pharmacology

Volumn 643, Issue 2-3, 2010, Pages 267-273

  Kimura, Mitsutoshi ^a   Watanabe, Makiko ^b   Ishibashi, Naoto ^b   Yanagida, Shingo ^b   Ogihara, Masahiko ^a  

^a JOSAI UNIVERSITY   (Japan)

^b KOWA COMPANY LTD   (Japan)

Author keywords

Acyclic retinoid (NIK 333); All trans retinoic acid; Liver regeneration; Partial hepatectomy; Retinol; Serum transaminase

Indexed keywords

NIK 333; POLYPRENOIC ACID; RETINOIC ACID; RETINOL; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DOSE RESPONSE; DRUG DOSE COMPARISON; LIVER CELL; LIVER REGENERATION; LIVER WEIGHT; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; WEIGHT GAIN;

EID: 77955269209     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.037     Document Type: Article

References (33)

1. Araki H., Shidoji Y., Yamada Y., Moriwaki H., Muto Y. Retinoid agonist activities of synthetic geranyl geranoic acid derivatives. Biochem. Biophys. Res. Commun. 1995, 209:66-72.
2. Assy N., Minuk G.Y. Liver regeneration: methods for monitoring and their applications. J. Hepatol. 1997, 26:945-952.
3. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J. 1996, 10:940-954.
4. de Almeida Vasconcelos Fonseca E.M., Chagas C.E., Mazzantini R.P., Heidor R., Ong T.P., Moreno F.S. All-trans and 9-cis retinoic acids, retinol and beta-carotene chemopreventive activities during the initial phases of hepatocarcinogenesis involve distinct actions on glutathione S-transferase positive preneoplastic lesions remodeling and DNA damage. Carcinogenesis 2005, 26:1940-1946.
5. Dragnev K.H., Rigas J.R., Dmitrovsky E. The retinoids and cancer prevention mechanisms. Oncologist 2000, 5:361-368.
6. Garattini E., Gianni M., Terao M. Cytodifferentiation by retinoids, a novel therapeutic option in oncology: rational combinations with other therapeutic agents. Vitam. Horm. 2007, 75:301-354.
7. Gratzner H.G. Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: a new reagent for detection of DNA replication. Science 1982, 218:474-475.
8. Hansen L.A., Sigman C.C., Andreola F., Ross S.A., Kelloff G.J., De Luka L.M. Retinoids in chemoprevention and differentiation therapy. Carcinogenesis 2000, 21:1271-1279.
9. Higgins G.M., Anderson R.M. Experimental pathology of the liver I. Restoration of the liver of the white rat following partial removal. Arch. Pathol. 1931, 12:186-202.
10. Ikeda H., Fujiwara K. Retinoic acid inhibits DNA and albumin synthesis stimulated by growth factor in adult rat hepatocytes in primary culture. Biochem. Biophys. Res. Commun. 1993, 191:675-680.
11. Ishiki Y., Ohnishi H., Muto Y., Matsumoto K., Nakamura T. Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo. Hepatology 1992, 16:1227-1235.
12. Kagawa M., Sano T., Ishibashi N., Hashimoto M., Okuno M., Moriwaki H., Suzuki R., Kohno H., Tanaka T. An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-α expression and cell proliferation. Carcinogenesis 2004, 25:979-985.
13. Kastner P., Mark M., Chambon P. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?. Cell 1995, 83:859-869.
14. Kimura M., Moro T., Motegi H., Maruyama H., Sekine M., Okamoto H., Inoue H., Sato T., Ogihara M. In vivo glycyrrhizin accelerates liver regeneration and rapidly lowers serum transaminase activities in 70% partially hepatectomized rats. Eur. J. Pharmacol. 2008, 579:357-364.
15. Kimura M., Ogihara M. Transforming growth factor-β1 inhibits the growth of primary adult rat hepatocyte cultures by increasing cAMP levels. Eur. J. Pharmacol. 1999, 386:271-277.
16. Komi Y., Sogabe Y., Ishibashi N., Sato Y., Moriwaki H., Shimokado K., Kojima S. Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway. Lab. Invest. 2010, 90:52-60.
17. Ledda-Columbano G.M., Pibiri M., Molotzu F., Cossu C., Sanna L., Simbula G., Perra A., Columbano A. Induction of hepatocyte proliferation by retinoic acid. Carcinogenesis 2004, 25:2061-2066.
18. McCormick D.L., Hollister J.L., Bagg B.J., Long R.E. Enhancement of murine hepatocarcinogenesis by all-trans-retinoic acid and two synthetic retinamides. Carcinogenesis 1990, 11:1605-1609.
19. Michalopoulos G.K., DeFrances M.C. Liver regeneration. Science 1997, 276:60-66.
20. Murphy K.A., Quadro L., White L.A. The intersection between the aryl hydrocarbon receptor (AhR)- and retinoic acid-signaling pathways. Vitam. Horm. 2007, 75:33-67.
21. Muto Y., Moriwaki H., Ninomiya M., Adachi S., Saito A., Takasaki K.T., Tanaka T., Tsurumi K., Okuno M., Tomita E., Nakamura T., Kojima T. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. New Engl. J. Med. 1996, 334:1561-1567.
22. Nakamura N., Shidoji Y., Moriwaki H., Muto Y. Apoptosis in human hepatoma cell line induced by 4, 5-didehydro geranylgeranoic acid (acyclic retinoid) via down-regulation of transforming growth factor-α. Biochem. Biophys. Res. Commun. 1996, 219:100-104.
23. Nakamura N., Shidoji Y., Yamada Y., Hatakeyama H., Moriwaki H., Muto Y. Induction of apoptosis by acyclic retinoid in the human hepatoma-derived cell line, HuH-7. Biochem. Biophys. Res. Commun. 1995, 207:382-388.
24. Nishikawa Y., Wang M., Carr B.I. Changes in TGF-β receptors of rat hepatocytes during primary culture and liver regeneration: Increased expression of TGF-β receptors associated with increased sensitivity to TGF-β-mediated growth inhibition. J. Cell. Physiol. 1998, 176:612-623.
25. Ohtake Y., Maruko A., Abe S., Nagashima T., Fukumoto M., Ohkubo Y. Involvement of retinoic acid-induced transglutaminase activity in zonal differences of hepatocyte proliferation after partial hepatectomy. J. Gastroenterol. Hepatol. 2006, 21:1726-1730.
26. Okuno M., Kojima S., Matsushima-Nishiwaki R., Tsurumi H., Muto Y., Friedman S.L., Moriwaki H. Retinoids in cancer chemoprevention. Curr. Cancer Drug Targets 2004, 4:285-298.
27. Ozeki A., Tsukamoto I. Retinoic acid repressed the expression of c-fos and c-jun and induced apoptosis in regenerating rat liver after partial hepatectomy. Biochim. Biophys. Acta. 1999, 1450:308-319.
28. Sakabe T., Tsuchiya H., Endo M., Tomita A., Ishii K., Gonda K., Murai R., Takubo K., Hoshikawa Y., Kurimasa A., Ishibashi N., Yanagida S., Shiota G. An antioxidant effect by acyclic retinoid suppresses liver tumor in mice. Biochem. Pharmacol. 2007, 73:1405-1411.
29. Sano T., Kagawa M., Okuno M., Ishibashi N., Hashimoto M., Yamamoto M., Suzuki R., Kohno H., Matsushima-Nishiwaki R., Takano Y., Tsurumi H., Kojima S., Friedman S.L., Moriwaki H., Tanaka T. Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-alpha-expressing oval-like cells and activated hepatic stellate cells. Nutr. Cancer 2005, 51:197-206.
30. CIP1 and inhibition of expression of cyclin D1. Cancer Res. 2002, 62:3997-4006.
31. Shidoji Y., Ogawa H. Natural occurrence of cancer-preventive geranylgeranoic acid in medicinal herbs. J. Lipid Res. 2004, 45:1092-1103.
32. Tsurumi H., Tojo A., Takahashi T., Ozawa K., Moriwakik H., Asano S., Muto Y. Differentiation induction of human promyelocytic leukemia cells by acyclic retinoid (polyprenoic acid). Int. J. Hematol. 1993, 59:9-15.
33. Yang X., Guo M., Wan Y.-J.Y. Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRα-deficient mouse livers. Am. J. Pathol. 2010, 176:733-743.