Penile Cancer: Clinical Presentation, Diagnosis, and Staging

Urologic Clinics of North America

Volumn 37, Issue 3, 2010, Pages 343-352

  Barocas, Daniel A ^a   Chang, Sam S ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Diagnosis; Penile cancer; Presentation; Staging

Indexed keywords

CANCER DIAGNOSIS; CANCER STAGING; CIGARETTE SMOKING; CLINICAL FEATURE; CONDYLOMA ACUMINATUM; DNA VIRUS INFECTION; HUMAN; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MALIGNANT TRANSFORMATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PENILE BIOPSY; PENIS CANCER; PHIMOSIS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK FACTOR; SENSITIVITY AND SPECIFICITY; TREATMENT PLANNING; TUMOR DIFFERENTIATION; WART VIRUS;

HUMANS; LYMPHATIC METASTASIS; MALE; NEOPLASM STAGING; PENILE NEOPLASMS;

EID: 77955265389     PISSN: 00940143     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ucl.2010.04.002     Document Type: Review

References (69)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2009. CA Cancer J Clin 2009, 59:225.
2. Hernandez B.Y., Barnholtz-Sloan J., German R.R., et al. Burden of invasive squamous cell carcinoma of the penis in the United States, 1998-2003. Cancer 2008, 113:2883.
3. Mobilio G., Ficarra V. Genital treatment of penile carcinoma. Curr Opin Urol 2001, 11:299.
4. Solsona E., Algaba F., Horenblas S., et al. EAU guidelines on penile cancer. Eur Urol 2004, 46:1.
5. Rippentrop J.M., Joslyn S.A., Konety B. Squamous cell carcinoma of the penis: evaluation of data from the surveillance, epidemiology, and end results program. Cancer 2004, 101:1357.
6. Horenblas S. Lymphadenectomy for squamous cell carcinoma of the penis. Part 2: the role and technique of lymph node dissection. BJU Int 2001, 88:473.
7. Lopes A., Bezerra A.L., Serrano S.V., et al. Iliac nodal metastases from carcinoma of the penis treated surgically. BJU Int 2000, 86:690.
8. Novara G., Galfano A., De Marco V., et al. Prognostic factors in squamous cell carcinoma of the penis. Nat Clin Pract Urol 2007, 4:140.
9. Ornellas A.A., Seixas A.L., Marota A., et al. Surgical treatment of invasive squamous cell carcinoma of the penis: retrospective analysis of 350 cases. J Urol 1994, 151:1244.
10. Ravi R. Correlation between the extent of nodal involvement and survival following groin dissection for carcinoma of the penis. Br J Urol 1993, 72:817.
11. Madsen B., Van Den Brule A., Jensen H., et al. Risk factors for squamous cell carcinoma of the penis-population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev 2008, 17:2683.
12. Maden C., Sherman K.J., Beckmann A.M., et al. History of circumcision, medical conditions, and sexual activity and risk of penile cancer. J Natl Cancer Inst 1993, 85:19.
13. Schoen E.J., Oehrli M., Colby C., et al. The highly protective effect of newborn circumcision against invasive penile cancer. Pediatrics 2000, 105:E36.
14. Dillner J., von Krogh G., Horenblas S., et al. Etiology of squamous cell carcinoma of the penis. Scand J Urol Nephrol Suppl 2000, 189.
15. Huben R.P., Sufrin G. Benign and malignant lesions of the penis. Adult and pediatric urology 1991, 1643. Mosby, St. Louis (MO). 2nd edition. J.Y. Gillenwater, J.T. Grayhack, S.S. Howards (Eds.).
16. Reddy C.R., Devendranath V., Pratap S. Carcinoma of penis-role of phimosis. Urology 1984, 24:85.
17. Miralles-Guri C., Bruni L., Cubilla A.L., et al. Human papillomavirus prevalence and type distribution in penile carcinoma. J Clin Pathol 2009, 62:870.
18. Boxer R.J., Skinner D.G. Condylomata acuminata and squamous cell carcinoma. Urology 1977, 9:72.
19. Smotkin D. Virology of human papillomavirus. Clin Obstet Gynecol 1989, 32:117.
20. Wiener J.S., Walther P.J. The association of oncogenic human papillomaviruses with urologic malignancy. The controversies and clinical implications. Surg Oncol Clin N Am 1995, 4:257.
21. Engels E.A., Pfeiffer R.M., Goedert J.J., et al. Trends in cancer risk among people with AIDS in the United States 1980-2002. AIDS 2006, 20:1645.
22. Daling J.R., Madeleine M.M., Johnson L.G., et al. Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer 2005, 116:606.
23. Harish K., Ravi R. The role of tobacco in penile carcinoma. Br J Urol 1995, 75:375.
24. Stern R.S. Genital tumors among men with psoriasis exposed to psoralens and ultraviolet A radiation (PUVA) and ultraviolet B radiation. The photochemotherapy follow-up study. N Engl J Med 1990, 322:1093.
25. Depasquale I., Park A.J., Bracka A. The treatment of balanitis xerotica obliterans. BJU Int 2000, 86:459.
26. Micali G., Nasca M.R., Innocenzi D., et al. Penile cancer. J Am Acad Dermatol 2006, 54:369.
27. Favorito L.A., Nardi A.C., Ronalsa M., et al. Epidemiologic study on penile cancer in Brazil. Int Braz J Urol 2008, 34:587.
28. Burgers J.K., Badalament R.A., Drago J.R. Penile cancer. Clinical presentation, diagnosis, and staging. Urol Clin North Am 1992, 19:247.
29. Gursel E.O., Georgountzos C., Uson A.C., et al. Penile cancer. Urology 1973, 1:569.
30. Hardner G.J., Bhanalaph T., Murphy G.P., et al. Carcinoma of the penis: analysis of therapy in 100 consecutive cases. J Urol 1972, 108:428.
31. Lynch H.T., Krush A.J. Delay factors in detection of cancer of the penis. Nebr State Med J 1969, 54:360.
32. Narayana A.S., Olney L.E., Loening S.A., et al. Carcinoma of the penis: analysis of 219 cases. Cancer 1982, 49:2185.
33. American Joint Committee on Cancer Penis. AJCC cancer staging manual 2010, 447. Springer, New York. 7th edition. S.B. Edge, D.R. Byrd, C.C. Compton (Eds.).
34. Cubilla A.L., Reuter V., Velazquez E., et al. Histologic classification of penile carcinoma and its relation to outcome in 61 patients with primary resection. Int J Surg Pathol 2001, 9:111.
35. Guimarães G.C., Cunha I.W., Soares F.A., et al. Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. J Urol 2009, 182:528.
36. Masih A.S., Stoler M.H., Farrow G.M., et al. Penile verrucous carcinoma: a clinicopathologic, human papillomavirus typing and flow cytometric analysis. Mod Pathol 1992, 5:48.
37. McKee P.H., Lowe D., Haigh R.J. Penile verrucous carcinoma. Histopathology 1983, 7:897.
38. Seixas A.L., Ornellas A.A., Marota A., et al. Verrucous carcinoma of the penis: retrospective analysis of 32 cases. J Urol 1994, 152:1476.
39. Velazquez E.F., Melamed J., Barreto J.E., et al. Sarcomatoid carcinoma of the penis: a clinicopathologic study of 15 cases. Am J Surg Pathol 2005, 29:1152.
40. International Union Against Cancer (UICC) Penis. TNM classification of malignant tumours 2009, 239. Wiley-Blackwell, Chichester, West Sussex (UK). 7th edition. L.H. Sobin, M.K. Gospodarowicz, C. Wittekind (Eds.).
41. Velazquez E.F., Barreto J.E., Rodriguez I., et al. Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma. Int J Surg Pathol 2004, 12:139.
42. Lont A.P., Besnard A.P., Gallee M.P., et al. A comparison of physical examination and imaging in determining the extent of primary penile carcinoma. BJU Int 2003, 91:493.
43. Petralia G., Villa G., Scardino E., et al. Local staging of penile cancer using magnetic resonance imaging with pharmacologically induced penile erection. Radiol Med 2008, 113:517.
44. Singh A.K., Saokar A., Hahn P.F., et al. Imaging of penile neoplasms. Radiographics 2005, 25:1629.
45. 18F-FDG-PET/CT for detection of pelvic nodal involvement in inguinal node-positive penile carcinoma. Eur Urol 2009, 56:339.
46. Kochhar R., Taylor B., Sangar V. Imaging in primary penile cancer: current status and future directions. Eur Radiol 2010, 20:36.
47. Krishna R.P., Sistla S.C., Smile R., et al. Sonography: an underutilized diagnostic tool in the assessment of metastatic groin nodes. J Clin Ultrasound 2008, 36:212.
48. Saisorn I., Lawrentschuk N., Leewansangtong S., et al. Fine-needle aspiration cytology predicts inguinal lymph node metastasis without antibiotic pretreatment in penile carcinoma. BJU Int 2006, 97:1225.
49. Spiess P.E., Izawa J.I., Bassett R., et al. Preoperative lymphoscintigraphy and dynamic sentinel node biopsy for staging penile cancer: results with pathological correlation. J Urol 2007, 177:2157.
50. Ficarra V., Zattoni F., Artibani W., et al. Nomogram predictive of pathological inguinal lymph node involvement in patients with squamous cell carcinoma of the penis. J Urol 2006, 175:1700.
51. Bhagat S., Gopalakrishnan G., Kekre N., et al. Factors predicting inguinal node metastasis in squamous cell cancer of penis. World J Urol 2010, 28(1):93-98.
52. Chaux A., Caballero C., Soares F., et al. The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma. Am J Surg Pathol 2009, 33(7):1049-1057.
53. Solsona E., Iborra I., Rubio J., et al. Prospective validation of the association of local tumor stage and grade as a predictive factor for occult lymph node micrometastasis in patients with penile carcinoma and clinically negative inguinal lymph nodes. J Urol 2001, 165:1506.
54. Novara G., Artibani W., Cunico S.C., et al. How accurately do Solsona and European Association of Urology risk groups predict for risk of lymph node metastases in patients with squamous cell carcinoma of the penis?. Urology 2008, 71:328.
55. Cubilla A.L. The role of pathologic prognostic factors in squamous cell carcinoma of the penis. World J Urol 2009, 27:169.
56. Dai B., Ye D.W., Kong Y.Y., et al. Predicting regional lymph node metastasis in Chinese patients with penile squamous cell carcinoma: the role of histopathological classification, tumor stage and depth of invasion. J Urol 2006, 176:1431.
57. Fraley E.E., Zhang G., Manivel C., et al. The role of ilioinguinal lymphadenectomy and significance of histological differentiation in treatment of carcinoma of the penis. J Urol 1989, 142:1478.
58. Lopes A., Hidalgo G.S., Kowalski L.P., et al. Prognostic factors in carcinoma of the penis: multivariate analysis of 145 patients treated with amputation and lymphadenectomy. J Urol 1996, 156:1637.
59. McDougal W.S. Carcinoma of the penis: improved survival by early regional lymphadenectomy based on the histological grade and depth of invasion of the primary lesion. J Urol 1995, 154:1364.
60. Slaton J.W., Morgenstern N., Levy D.A., et al. Tumor stage, vascular invasion and the percentage of poorly differentiated cancer: independent prognosticators for inguinal lymph node metastasis in penile squamous cancer. J Urol 2001, 165:1138.
61. Velazquez E.F., Ayala G., Liu H., et al. Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm. Am J Surg Pathol 2008, 32:974.
62. Kayes O., Ahmed H., Arya M., et al. Molecular and genetic pathways in penile cancer. Lancet Oncol 2007, 8:420.
63. Kroon B.K., Leijte J.A., van Boven H., et al. Microarray gene-expression profiling to predict lymph node metastasis in penile carcinoma. BJU Int 2008, 102:510.
64. Ficarra V., Martignoni G., Maffei N., et al. Predictive pathological factors of lymph nodes involvement in the squamous cell carcinoma of the penis. Int Urol Nephrol 2002, 34:245.
65. Cubilla A.L., Piris A., Pfannl R., et al. Anatomic levels: important landmarks in penectomy specimens: a detailed anatomic and histologic study based on examination of 44 cases. Am J Surg Pathol 2001, 25:1091.
66. Srinivas V., Morse M.J., Herr H.W., et al. Penile cancer: relation of extent of nodal metastasis to survival. J Urol 1987, 137:880.
67. Svatek R.S., Munsell M., Kincaid J.M., et al. Association between lymph node density and disease specific survival in patients with penile cancer. J Urol 2009, 182:2721.
68. Kattan M.W., Ficarra V., Artibani W., et al. Nomogram predictive of cancer specific survival in patients undergoing partial or total amputation for squamous cell carcinoma of the penis. J Urol 2006, 175:2103.
69. Zini L., Cloutier V., Isbarn H., et al. A simple and accurate model for prediction of cancer-specific mortality in patients treated with surgery for primary penile squamous cell carcinoma. Clin Cancer Res 2009, 15:1013.