The role of pathologic prognostic factors in squamous cell carcinoma of the penis

World Journal of Urology

Volumn 27, Issue 2, 2009, Pages 169-177

  Cubilla, Antonio L ^a  

^a UNIVERSIDAD NACIONAL DE ASUNCIÓN   (Paraguay)

Author keywords

Carcinoma; Factors; Pathologic; Penis; Prognosis

Indexed keywords

CANCER INVASION; HUMAN; MALE; PATHOLOGY; PENIS TUMOR; PROGNOSIS; REVIEW; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; HUMANS; MALE; NEOPLASM INVASIVENESS; PENILE NEOPLASMS; PROGNOSIS;

EID: 63649158558     PISSN: 07244983     EISSN: 14338726     Source Type: Journal    
DOI: 10.1007/s00345-008-0315-7     Document Type: Review

References (62)

1. Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB (2003) Cancer incidence in five continents. IARC Scientific Publications No 155. IARC Press, Lyon
2. Rubin MA, Kleter B, Zhou M, Ayala G, Cubilla AL, Quint WG, Pyrog EC et al (2001) Detection and typing of human papillomavirus DNA in penile carcinoma: Evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol 159:1211-1218
3. Cubilla AL, Tamboli P, Amin M, Velazquez E, Ro JY, Ayala AG (2000) Geographical comparison of subtypes of squamous cell carcinoma of the penis from regions of high and low incidence. Lab Invest 80:97A
4. Aynaud O, Asselain B, Bergeron C, Cartier I, Martin E, Sastre-Garau X et al (2000) Intraepithelial carcinoma and invasive carcinoma of vulva, vagina and penis in Ile-de-France. Ann Dermatol Venereol 127:479-483
5. Barreto JE, Caballero C, Cubilla AL (1997) Penis. In: Sternberg SS (ed) Histology by pathologists, 2nd edn. Lippincott-Raven, Philadelphia
6. Cubilla AL, Velazquez EF, Barreto JE (2004) Penis. In Sternberg's Diagnostic Surgical Pathology, Lippincot-Raven
7. Cubilla AL, Dillner J, Schellhammer PF, Horenblas S (2003) Malignant epithelial tumors. In: Tumors of the penis. Pathology & Genetics. Tumors of the Urinary System and Male Genital Organs, WHO. IARC Press, Lyon
8. Cabanas RM (1997) An approach for the treatment of penile carcinoma. Cancer 39:456-466. doi:10.1002/ 1097-0142(197702)39:2<456::AID-CNCR2820390214>3.0.CO;2-I
9. Leijte JA, Kroon BK, Valdes Olmos RA, Nieweg OE, Horenblas S (2007) Reliability and safety of current dynamic sentinel node biopsy for penile carcinoma. Eur Urol 52:170-177. doi: 10.1016/j.eururo.2007.01.107
10. Kroon BK, Horenblas S, Meinhardt W, van der Poel HG, Bex A, van Tinteren H et al (2005) Dynamic sentinel biopsy in penile carcinoma: Evaluation of 10 years experience. Eur Urol 47:601-606. doi: 10.1016/ j.eururo.2004.11.018
11. Cubilla AL, Reuter V, Velazquez EF, Piris A, Saito S, Young RH (2001) Histologic classification of penile carcinoma and its relation to outcome in 61 patients with primary resection. Int J Surg Pathol 9:111-120. doi: 10.1177/106689690100900204
12. Novara G, Galfano A, De Marco V, Artibani W, Ficarra V (2007) Prognostic factors in squamous cell carcinoma of the penis. Nat Clin Pract Urol 4:140-146. doi: 10.1038/ncpuro0751
13. Cubilla AL, Velazquez EF, Codas R, Reuter V (2004) Autopsy findings in 14 patients with penile squamous cell carcinoma. Mod Pathol 17:5A
14. Velazquez EF, Barreto JE, Rodriguez I, Piris A, Cubilla AL (2004) Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma. Int J Surg Pathol 12:139-146. doi: 10.1177/ 106689690401200207
15. Ficarra V, Zattoni F, Cunisco SC, Galetti TP, Luciani L, Fandella A et al (2005) Lymphatic and vascular embolizations are independent predictive variables of inguinal node involvement in patients with squamous cell carcinoma of the penis. Cancer 103:2507-2516. doi: 10.1002/ cncr.21076
16. Horenblas S, van Tinteren H (1994) Squamous cell carcinoma of the penis. IV. Prognostic factors of survival: Analysis of tumor, nodes and metastasis classification system. J Urol 151:1239-1243
17. Soria JC, Fizazi K, Piron D, Kramar A, Gerbaulet A, Haie-Meder C et al (1997) Squamous cell carcinoma of the penis: Multivariate analysis of prognostic factors and natural history in monocentric study with a conservative policy. Ann Oncol 8:189-1098. doi: 10.1023/A:1008248319036
18. Fraley EE, Zhang Z, Manivel C, Niehans CA (1989) The role of inguinal lymphadenectomy and significance of histological differentiation in treatment of carcinoma of the penis. J Urol 142:1478-1482
19. Ficarra V, Martignoni G, Maffei N, Cerruto MA, Novara G, Cavalleri S et al (2002) Predictive pathological factors of lymph node involvement in the squamous cell carcinoma of the penis. Int Urol Nephrol 34:245-250. doi: 10.1023/A:1023243102230
20. Lopez AA, Hidalgo GS, Kowalski LP, Torloni H, Rossi BM, Fonseca FP (1996) Prognostic factors in carcinoma of the penis: Multivariate analysis of 145 patients treated with amputation and lymphadenectomy. J Urol 156:1637-1642. doi: 10.1016/S0022-5347(01)65471-5
21. Velazquez EF, Ayala GE, Liu H, Chaux A, Zanotti M, Torres J, Cho SI, Barreto JE, Soares F, Cubilla AL (2008) Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm. Am J Surg Pathol 32(7):974-999
22. Cubilla AL, Ayala G, Lopez A, Guimaraes GC, Oliveria ML, Torres JJ et al (2007) Perineural invasion (PNI) predicts mortality in penile squamous cell carcinoma. A long term outcome study comparing clinico-pathologic features. Lab Invest 87A:142
23. Caballero C, Barreto J, Riveros M, Cubilla AL (1991) Carcinoma epidermoide de glande peneano: Parametros patologicos predictores de metastasis ganglionar inguinal. Patol Spain 24:1137-1141
24. Solsona E, Iborra I, Ricos JV, Monros JL, Dumont R, Casanova J (1992) Corpus cavernosum invasion and tumor grade in the prediction of lymph node condition in penile carcinoma. Eur Urol 22:115-118
25. Solsona E, Iborra I, Rubio J, Casanova JL, Ricos JV, Calabuig C (2001) Prospective validation of the association of local tumor stage and grade as a predictive factor for occult lymph node micrometastasis in patients with penile carcinoma and clinically negative inguinal lymph nodes. J Urol 165:1506-1509. doi: 10.1016/S0022-5347(05)66337-9
26. McDougal WS (1995) Carcinoma of the penis: Improved survival by early regional lymphadenectomy based on the histologic grade and depth of invasion of the primary lesion. J Urol 154:1364-1366. doi: 10.1016/ S0022-5347(01)66863-0
27. Kattan MW, Ficarra V, Artibani W, Cunico SC, Fandella A, Martignoni G et al (2006) Nomogram predictive of cancer specific survival in patients undergoing partial or total amputation for squamous cell carcinoma of the penis. J Urol 175:2103-2108. doi: 10.1016/S0022-5347(06)00313-2
28. Ficarra V, Zattoni F, Artibani W, Fandella A, Martignoni G, Novara G et al (2006) Nomogram predictive of pathological inguinal lymph node involvement in patients with squamous cell carcinoma of the penis. J Urol 175:1700-1705. doi: 10.1016/S0022-5347(05)01003-7
29. Slaton JW, Morgenstern N, Levy DA, Santos MW Jr, Tamboli P, Ro JY et al (2001) Tumor stage, vascular invasion and the percentage of poorly differentiated cancer: Independent prognosticators for inguinal node metastasis in penile squamous cancer. J Urol 165:1138-1142. doi: 10.1016/ S0022-5347(05)66450-6
30. Adeyouju AB, Thornhill J, Corr J, Grainger R, McDermott TE, Butler M (1997) Prognostic factors in squamous cell carcinoma of the penis and implications for management. Br J Urol 80(6):937-939
31. Rubio-Briones J, Villavicencio H, Regalado R, Chechile G, Algaba F, Monreal F et al (1997) Squamous cell carcinoma of the penis: Treatment protocol according to our 14 years experience. Arch Esp Urol 50:473-480
32. Young RH, Srigley JR, Amin MB, Cubilla AL (2000) Tumors of the prostate gland, seminal vesicles, male urethra and penis. Armed Forces Institute of Pathology fascicle, Third Series, Washington DC
33. Cubilla AL, Chaux A, Pfannl R, Torres J, Barreto JE, Velazquez EF (2005) Any proportion of histological grade 3 is related to metastasis in SCC of the penis. An electronically quantified study of proportion of grades. Mod Pathol 18A:135
34. Velazquez EF, Soskin A, Bock A, Codas R, Barreto JE, Cubilla AL (2004) Positive resection margins in partial penectomies: Sites of involvement and proposal of local routes of spread of penile squamous cell carcinoma. Am J Surg Pathol 28:384-389. doi: 10.1097/ 00000478-200403000-00012
35. Cubilla AL, Velazquez EF, Ayala GE, Chaux A, Torres J, Reuter V (2005) Identification of prognostic pathologic parameters in squamous cell carcinoma of the penis: Significance and difficulties. Pathol Case Rev 10:3-13. doi: 10.1097/01.pcr.0000153239.13371.58
36. Emerson RE, Ulbright TM, Eble JN, Geary WA, Eckert GJ, Cheng L (2001) Predicting cancer progression in patients with penile squamous cell carcinoma: The importance of depth of invasion and vascular invasion. Mod Pathol 14:963-968. doi: 10.1038/modpathol.3880419
37. Hall MC, Sanders JS, Viutch F, Ramirez E, Pettaway CA (1998) Deoxyribonucleic acid flow cytometry and traditional pathologic variables in invasive penile carcinoma: Assessment of prognostic significance. Urology 52:111-116. doi: 10.1016/S0090-4295(98)00137-X
38. Soares FA, Werneck da Cunha I, Lima de Oliveira l, Guimaraes GC, Velazquez EF, Torres JJ, Chaux A, Cubilla AL (2007) Grade is more influential than depth of invasion in penile SCCs. An outcome study of paradoxical high grade superficial and deeply invasive low grade tumors. Lab Inv 177A
39. Cubilla AL, Piris A, Pffanl R, Rodríguez I, Agüero F, Young RH (2001) Anatomic levels: Important landmarks in penectomy specimens; a detailed anatomic and histologic study based on the examination of 44 specimens. Am J Surg Pathol 25:1091-1094. doi: 10.1097/ 00000478-200108000-00016
40. Oertel J, Duarte S, Ayala J, Chaux A, Velazquez EF, Cubilla AL (2002) Squamous cell carcinoma exclusive of the foreskin: Distinctive association with low grade variants, multicentricity and lichen sclerosus. Mod Pathol 15:175A
41. Velazquez EF, Soskin A, Bock A, Codas R, Cai G, Barreto JE et al (2005) Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: A report of 89 cases. Mod Pathol 18:917-923. doi: 10.1038/modpathol.3800371
42. Huvos A, Grabstald H (1973) Urethral meatal and perimeatal tumors in young men: A clinicopathologic and electronmicroscopic study. J Urol 10:688-692
43. Alonso E, Marostica A, Roma S, Redin I, SanchezMazzaferri F, Toffoni C (1997) Low grade papillary transitional cell carcinoma of the distal urethra with focal squamous differentiation and association with human papilloma virus types 6-11. Arch Esp Urol 50:875-878
44. Arya M, Brown RW, Hayne D, Patel HR, Harland SJ (2001) Primary anterior urethral transitional cell carcinoma: A rare tumor. Surg Oncol 27:607-608. doi: 10.1053/ejso.2001.1135
45. Bans LL, Eble JN, Lingeman JE, Maynard BR (1983) Transitional cell carcinoma of fossa navicularis of the male urethra. J Urol 120:1055-1056
46. Cupp MR, Malek RS, Goellner JS, Espy MJ, Smith TF (1996) Detection of human papillomavirus DNA in primary squamous cell carcinoma of the male urethra. Urol 48:551-555. doi: 10.1016/S0090-4295(96)00246-4
47. Dalbagni G, Zhang ZF, Lacombe I, Herr HW (1999) Male urethral carcinoma: analysis of treatment outcome. Urology 53:1126-1132. doi: 10.1016/ S0090-4295(98)00659-1
48. Cubilla AL, Barreto JE, Caballero C, Ayala G, Riveros M (1993) Pathologic features of epidermoid carcinoma of the penis. A prospective study of 66 cases. Am J Surg Pathol 17:753-763. doi: 10.1097/ 00000478-199308000-00001
49. Villavicencio H, Rubio-Briones J, Regalado R, Chéchile G, Algaba F, Palou J (1997) Grade, local stage and growth pattern as prognostic factors in carcinoma of the penis. Eur Urol 32:442-447
50. Guimaraes GC, Lopez A, Campos RS, Zequi Sde C, Leal ML, Carvalho AL et al (2006) Front pattern of invasion in squamous cell carcinoma of the penis: New prognostic factor for predicting risk of lymph node metastasis. Urology 68:148-153. doi: 10.1016/j.urology.2006.01.050
51. Guimaraes G, Werneck da Cunha I, Soares F, Lopez A, Torres JJ, Chaux A, Velazquez EF, Cubilla AL (2007) WHO histological classification, regional metástasis and outcome in 375 surgically treated patients with penile SCC. Mod Pathol 20:150A. doi: 10.1038/ sj.modpathol.3800806
52. Cubilla AL, Velazques EF, Reuter VE, Oliva E, Mihm MC Jr, Young RH (2000) Warty (condylomatous) squamous cell carcinoma of the penis: A report of 11 cases and proposed classification of verruciform tumors penile tumors. Am Surg Path 24:505-512. doi: 10.1097/ 00000478-200004000-00004
53. Cubilla AL, Velazquez EF, Young RH (2004) Pseudohyperplastic squamous cell carcinoma of the penis associated with lichen slcerosus. An extremely well differentiated nonverruciform neoplasm that preferentially affects the foreskin and is frequently misdiagnosed: A report of 10 cases of a distinctive clinicopathologic entity. Am J Surg Pathol 28:895-900. doi: 10.1097/00000478-200407000-00008
54. Barreto JE, Velazquez EF, Ayala E, Torres J, Cubilla AL (2007) Carcinoma cuniculatum of the penis: A distinctive variant of penile squamous cell carcinoma: Report of 7 cases. Am J Surg Path 31:71-75
55. Cubilla AL, Reuter VE, Gregoire L, Ayala G, Ocampos S, Lancaster WD et al (1998) Basaloid squamous cell carcinoma: A distinctive HPV related penile neoplasm: A report of 20 cases. Am J Surg Pathol 22:751-761. doi: 10.1097/00000478-199806000-00014
56. Velazquez EF, Melamed J, Barreto JE, Aguero F, Cubilla AL (2005) Sarcomatoid carcinoma of the penis. A clinico-pathological study of 14 cases. Am J Surg Pathol 29:1152-1158. doi: 10.1097/ 01.pas.0000160440.46394.a8
57. Dai B, Kong YY, Yao XD, Zhang HL, Shen YJ (2006) Predicting lymph node metastasis in Chinese patients with penile squamous cell carcinoma: The role of histopathologic classification, tumor stage and depth of invasion. J Urol 176:1431-1435. doi: 10.1016/j.juro.2006.06.024
58. de Paula AA, Netto JC, Freitas R Jr, de Paula LP, Mota ED, Alencar RC (2007) Penile carcinoma: The role of koilocytosis in groin metastasis and the association with disease specific survival. J Urol 177:1339-1343. doi: 10.1016/j.juro.2006.11.063
59. Santos M, Montagut C, Mellado B, Garcia A, Ramon y Cajal S, Cardesa A, Puig-Tintoré LM, Ordi J (2004) Immunohistochemical staining for p16 and p53 in premalignant and malignant epithelial lesions of the vulva. Int J Gynecol Pathol 23:206-214. doi: 10.1097/ 01.pgp.0000130108.03231.89
60. Maiche AG, Pyrhonen S, Karkinen M (1991) Histological grading of squamous cell carcinoma of the penis: A new scoring system. Br J Urol 67:522-526
61. Cubilla AL, Caballero C, Piris A, Reuter VE (2000) Prognostic Index (PI): A novel method to predict mortality in squamous cell carcinoma of the penis. Lab Inv 80:97A
62. Ono Y, Osawa M, Tamura Y, Suzuki T, Suzuki K, Kurokawa K et al (2002) Tumor-associated tissue eosinophilia of penile cancer. Int J Urol 9:82-87. doi: 10.1046/j.1442-2042.2002.00424.x