Pharmacokinetics, analgesic effect, and tolerability of a single preprocedural dose of intranasal fentanyl in patients undergoing drain removal after breast reduction or augmentation surgery: A prospective, randomized, double-blind, placebo-controlled study

Clinical Therapeutics

Volumn 32, Issue 7, 2010, Pages 1427-1436

  Veldhorst Janssen, Nicole M L ^a   Fiddelers, Audrey A A ^a   van der Kuy, Paul Hugo M ^b   Kessels, Alfons G H ^a   Theunissen, H Maurice S ^a   van der Hulst, René R W J ^a   Neef, Cees ^a   Marcus, Marco A E ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Sittard Geleen Heerlen   (Netherlands)

Author keywords

Fentanyl; Intranasal; Opioids; Postoperative pain

Indexed keywords

FENTANYL; PLACEBO;

ADULT; ANALGESIC ACTIVITY; ARTICLE; BLOOD PRESSURE; BREAST AUGMENTATION; BREAST REDUCTION; BREATHING RATE; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEVICE REMOVAL; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG TOLERABILITY; FEMALE; HEART RATE; HUMAN; MAXIMUM PLASMA CONCENTRATION; NASAL PRURITUS; NAUSEA; NOSE MUCUS; NOSE TINGLING; OXYGEN SATURATION; PAIN; RANDOMIZED CONTROLLED TRIAL; SENSATION; SIDE EFFECT; SINGLE DRUG DOSE; SOMNOLENCE; STRESSED FEELING; WEAKNESS;

ADMINISTRATION, INTRANASAL; ADOLESCENT; ADULT; ANALGESICS, OPIOID; DEVICE REMOVAL; DOUBLE-BLIND METHOD; DRAINAGE; FEMALE; FENTANYL; HUMANS; MAMMAPLASTY; MIDDLE AGED; PAIN; PAIN MEASUREMENT; PROSPECTIVE STUDIES; TIME FACTORS; YOUNG ADULT;

EID: 77955260161     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2010.07.001     Document Type: Article

References (23)

1. Barnard J, Thompson J, Dunning J Can any intervention effectively reduce the pain associated with chest drain removal?. Interact Cardiovasc Thorac Surg. 2004, 3:229-232.
2. Friesner SA, Curry DM, Moddeman GR Comparison of two pain-management strategies during chest tube removal: Relaxation exercise with opioids and opioids alone. Heart Lung 2006, 35:269-276.
3. Tveita T, Thoner J, Klepstad P, et al. A controlled comparison between single doses of intravenous and intramuscular morphine with respect to analgesic effects and patient safety. Acta Anaesthesiol Scand. 2008, 52:920-925.
4. Striebel HW, Kramer J, Luhmann I, et al. Pharmacokinetic study of intranasal fentanyl [in German]. Schmerz. 1993, 7:122-125.
5. Lim SC, Paech MJ, Sunderland VB, et al. Pharmacokinetics of nasal fentanyl. J Pharm Pract Res. 2003, 33:59-63.
6. Striebel HW, Oelmann T, Spies C, et al. Patient-controlled intranasal analgesia: A method for noninvasive postoperative pain management. Anesth Analg. 1996, 83:548-551.
7. Huynh NH, Tyrefors N, Ekman L, Johansson M Determination of fentanyl in human plasma and fentanyl and norfentanyl in human urine using LC-MS/MS. J Pharm Biomed Anal. 2005, 37:1095-1100.
8. Schouten HJ Klinische Statistiek: Een Praktische Inleiding in Methodologie en Analyse 1999, Bohn Stafleu Van Loghum, Houten/Diegem.
9. Foster D, Upton R, Christrup L, Popper L Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery. Ann Pharmacother. 2008, 42:1380-1387.
10. Mantha S, Thisted R, Foss J, et al. A proposal to use confidence intervals for visual analog scale data for pain measurement to determine clinical significance [published correction appears in Anesth Analg. 1994;78:1035]. Anesth Analg. 1993, 77:1041-1047.
11. Sommer M, Geurts JW, Stessel B, et al. Prevalence and predictors of postoperative pain after ear, nose, and throat surgery. Arch Otolaryngol Head Neck Surg. 2009, 135:124-130.
12. Field AP Discovering Statistics Using SPSS: And Sex and Drugs and Rock n' Roll 2009, Sage Publications, Los Angeles, Calif.
13. Krueger C, Tian L A comparison of the general linear mixed model and repeated measures ANOVA using a dataset with multiple missing data points. Biol Res Nurs. 2004, 6:151-157.
14. Proost JH, Meijer DK MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring. Comput Biol Med. 1992, 22:155-163.
15. Jelliffe RW, Schumitzky A, Bayard D, et al. Model-based, goal-oriented, individualised drug therapy. Linkage of population modelling, new multiple model' dosage design, bayesian feedback and individualised target goals. Clin Pharmacokinet. 1998, 34:57-77.
16. Jelliffe RW, Schumitzky A, Van Guilder M, et al. Individualizing drug dosage regimens: Roles of population pharmacokinetic and dynamic models, Bayesian fitting, and adaptive control. Ther Drug Monit. 1993, 15:380-393.
17. Bonate PL A brief introduction to Monte Carlo simulation. Clin Pharmacokinet. 2001, 40:15-22.
18. Gourlay GK, Kowalski SR, Plummer JL, et al. Fentanyl blood concentrationanalgesic response relationship in the treatment of postoperative pain. Anesth Analg. 1988, 67:329-337.
19. Peng PW, Sandler AN A review of the use of fentanyl analgesia in the management of acute pain in adults. Anesthesiology 1999, 90:576-599.
20. Hummel P, van Dijk M Pain assessment: Current status and challenges. Semin Fetal Neonatal Med. 2006, 11:237-245.
21. Christrup LL, Foster D, Popper LD, et al. Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing thirdmolar extraction: A randomized, double-blind, double-dummy, two-way, crossover study. Clin Ther. 2008, 30:469-481.
22. Moksnes K, Fredheim OM, Klepstad P, et al. Early pharmacokinetics of nasal fentanyl: Is there a significant arterio-venous difference?. Eur J Clin Pharmacol. 2008, 64:497-502.
23. Veldhorst-Janssen NM, Fiddelers AA, van der Kuy PH, et al. A review of the clinical pharmacokinetics of opioids, benzodiazepines, and antimigraine drugs delivered intranasally. Clin Ther. 2009, 31:2954-2987.