Pharmacological activation of IKr impairs conduction in guinea pig hearts

Journal of Cardiovascular Electrophysiology

Volumn 21, Issue 8, 2010, Pages 923-929

  Larsen, Anders Peter ^a   Olesen, SØren Peter ^a   Grunnet, Morten ^a,b   Poelzing, Steven ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NEUROSEARCH A S   (Denmark)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

arrhythmias; conduction velocity; hERG agonist; IKr; long QT syndrome; NS3623

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; FLECAINIDE; NS 3623; POTASSIUM CHANNEL AFFECTING AGENT; POTASSIUM CHANNEL HERG; SODIUM CHANNEL; UNCLASSIFIED DRUG; ANTIARRHYTHMIC AGENT; CARBANILAMIDE DERIVATIVE; PIPERIDINE DERIVATIVE; POTASSIUM; POTASSIUM CHANNEL BLOCKING AGENT; PYRIDINE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT; TETRAZOLE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; GUINEA PIG; HEART CONDUCTION; HEART PERFUSION; ION CURRENT; MALE; NONHUMAN; PRIORITY JOURNAL; QRS COMPLEX; RAPID DELAYED RECTIFIER CURRENT; REGULATORY MECHANISM; ACTION POTENTIAL; ANIMAL; HEART ARRHYTHMIA; HEART MUSCLE CONDUCTION SYSTEM; HEART PACING; IN VITRO STUDY; METABOLISM; PATHOPHYSIOLOGY; PERFUSION; TIME; VOLTAGE SENSITIVE DYE IMAGING;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; CARDIAC PACING, ARTIFICIAL; ETHER-A-GO-GO POTASSIUM CHANNELS; FLECAINIDE; GUINEA PIGS; HEART CONDUCTION SYSTEM; MALE; PERFUSION; PHENYLUREA COMPOUNDS; PIPERIDINES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; PYRIDINES; SODIUM CHANNEL BLOCKERS; TETRAZOLES; TIME FACTORS; VOLTAGE-SENSITIVE DYE IMAGING;

EID: 77955237432     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2010.01733.x     Document Type: Article

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