1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin β, a substrate of parkin, and reduces its polyubiquitination

Journal of Neurochemistry

Volumn 114, Issue 5, 2010, Pages 1291-1301

  Kohta, Ryuki ^a   Kotake, Yaichiro ^a   Hosoya, Takamitsu ^b,c,d   Hiramatsu, Toshiyuki ^b,c   Otsubo, Yuko ^b   Koyama, Hiroko ^b   Hirokane, Yuji ^a   Yokoyama, Yuichi ^a   Ikeshoji, Hirofumi ^e   Oofusa, Ken ^e   Suzuki, Masaaki ^b,f   Ohta, Shigeru ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e Pro Phoenix   (Japan)

^f RIKEN   (Japan)

Author keywords

parkin; Parkinson's disease; polyubiquitination; radioisotope free photoaffinity labeling; tetrahydroisoquinoline; tubulin

Indexed keywords

1 (3 AZIDO 5 AZIDOMETHYLBENZYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; BETA TUBULIN; NEUROTOXIN; PARKIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; NEUROBLASTOMA; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN BINDING; RAT; UBIQUITINATION;

ANIMALS; CELL LINE, TUMOR; DOWN-REGULATION; HUMANS; MICE; NEUROTOXINS; PARKINSON DISEASE; POLYUBIQUITIN; PROTEIN BINDING; SUBSTRATE SPECIFICITY; TETRAHYDROISOQUINOLINES; TUBULIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

PARKINSONIA;

EID: 77955130866     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06576.x     Document Type: Article

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