메뉴 건너뛰기




Volumn 117, Issue 1, 2003, Pages 63-70

Neurotoxicity of an endogenous brain amine, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, in organotypic slice co-culture of mesencephalon and striatum

Author keywords

Dopamine content; Neuronal death; Parkinson's disease; Tyrosine hydroxylase positive neuron

Indexed keywords

1 BENZYL 1,2,3,4 TETRAHYDROISOQUINOLINE; AMINE; DOPAMINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0037451791     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00789-3     Document Type: Article
Times cited : (32)

References (53)
  • 1
    • 0035854586 scopus 로고    scopus 로고
    • Biochemical and pathological study of endogenous 1-benzyl-1, 2, 3, 4-tetrahydroisoquinoline-induced parkinsonism in the mouse
    • Abe K., Taguchi K., Wasai T., Ren J., Utsunomiya I., Shinohara T., Miyatake T., Sano T. Biochemical and pathological study of endogenous 1-benzyl-1, 2, 3, 4-tetrahydroisoquinoline-induced parkinsonism in the mouse. Brain Res. 907:2001;134-138.
    • (2001) Brain Res , vol.907 , pp. 134-138
    • Abe, K.1    Taguchi, K.2    Wasai, T.3    Ren, J.4    Utsunomiya, I.5    Shinohara, T.6    Miyatake, T.7    Sano, T.8
  • 2
    • 0032560486 scopus 로고    scopus 로고
    • Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • Ara J., Przedborski S., Naini A.B., Jackson-Lewis V., Trifiletti R.R., Horwitz J., Ischiropoulos H. Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Proc Natl Acad Sci USA. 95:1998;7659-7663.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7659-7663
    • Ara, J.1    Przedborski, S.2    Naini, A.B.3    Jackson-Lewis, V.4    Trifiletti, R.R.5    Horwitz, J.6    Ischiropoulos, H.7
  • 5
    • 0027444263 scopus 로고
    • Structural modifications associated with synaptic development in area CA1 of rat hippocampal organotypic cultures
    • Buchs P.A., Stoppini L., Muller D. Structural modifications associated with synaptic development in area CA1 of rat hippocampal organotypic cultures. Dev Brain Res. 71:1993;81-91.
    • (1993) Dev Brain Res , vol.71 , pp. 81-91
    • Buchs, P.A.1    Stoppini, L.2    Muller, D.3
  • 6
    • 0001496694 scopus 로고
    • A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Burns R.S., Chiueh C.C., Markey S.P., Ebert M.H., Jacobowitz D.M., Kopin I.J. A primate model of parkinsonism selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA. 80:1983;4546-4550.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4546-4550
    • Burns, R.S.1    Chiueh, C.C.2    Markey, S.P.3    Ebert, M.H.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 7
    • 0033600443 scopus 로고    scopus 로고
    • Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: A case-control study
    • Caparros-Lefebvre D., Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants a case-control study. Lancet. 354:1999;281-286.
    • (1999) Lancet , vol.354 , pp. 281-286
    • Caparros-Lefebvre, D.1    Elbaz, A.2
  • 8
    • 0028176878 scopus 로고
    • + in PC12 cells: Insights into potential neurotoxicants in Parkinson's disease
    • + in PC12 cells insights into potential neurotoxicants in Parkinson's disease. J Neurochem. 62:1994;1503-1510.
    • (1994) J Neurochem , vol.62 , pp. 1503-1510
    • Cobuzzi, R.J.1    Neafsey, E.J.2    Collins, M.A.3
  • 9
    • 0027159165 scopus 로고
    • The N-methyl-D-aspartate antagonist MK-801 fails to protect dopaminergic neurons from MPTP toxicity in vitro
    • Finiels-Marlier F., Marini A.M., Willians P., Paul S.M. The N-methyl-D-aspartate antagonist MK-801 fails to protect dopaminergic neurons from MPTP toxicity in vitro. J Neurochem. 60:1993;1968-1971.
    • (1993) J Neurochem , vol.60 , pp. 1968-1971
    • Finiels-Marlier, F.1    Marini, A.M.2    Willians, P.3    Paul, S.M.4
  • 10
    • 0022466381 scopus 로고
    • Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys
    • Forno L.S., Langston J.W., DeLanney L.E., Irwin I., Ricaurte G.A. Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann Neurol. 20:1986;449-455.
    • (1986) Ann Neurol , vol.20 , pp. 449-455
    • Forno, L.S.1    Langston, J.W.2    DeLanney, L.E.3    Irwin, I.4    Ricaurte, G.A.5
  • 11
    • 0023795276 scopus 로고
    • Organotypic cultures of neural tissue
    • Gähwiler B.H. Organotypic cultures of neural tissue. Trends Neurosci. 11:1988;484-489.
    • (1988) Trends Neurosci , vol.11 , pp. 484-489
    • Gähwiler, B.H.1
  • 12
    • 0028889913 scopus 로고
    • Cerebrospinal fluid of Parkinson's disease patients inhibits the growth and function of dopaminergic neurons in culture
    • Hao R., Norgren R.B. Jr, Lau Y., Pfeiffer R.F. Cerebrospinal fluid of Parkinson's disease patients inhibits the growth and function of dopaminergic neurons in culture. Neurology. 45:1995;138-142.
    • (1995) Neurology , vol.45 , pp. 138-142
    • Hao, R.1    Norgren R.B., Jr.2    Lau, Y.3    Pfeiffer, R.F.4
  • 13
    • 0028821782 scopus 로고
    • Selegiline protects dopaminergic neurons in culture from toxic factor(s) present in the cerebrospinal fluid of patients with Parkinson's disease
    • Hao R., Ebadi M., Pfeiffer R.F. Selegiline protects dopaminergic neurons in culture from toxic factor(s) present in the cerebrospinal fluid of patients with Parkinson's disease. Neurosci Lett. 200:1995;77-80.
    • (1995) Neurosci Lett , vol.200 , pp. 77-80
    • Hao, R.1    Ebadi, M.2    Pfeiffer, R.F.3
  • 14
    • 0024348978 scopus 로고
    • Cytotoxic effects of acrylamide and its related compounds assessed by protein content, LDH activity and cumulative glucose consumpution of neuron-rich cultures in a chemically defined medium
    • Hayashi M., Tanii H., Horiguchi M., Hashimoto K. Cytotoxic effects of acrylamide and its related compounds assessed by protein content, LDH activity and cumulative glucose consumpution of neuron-rich cultures in a chemically defined medium. Arch Toxicol. 63:1989;308-313.
    • (1989) Arch Toxicol , vol.63 , pp. 308-313
    • Hayashi, M.1    Tanii, H.2    Horiguchi, M.3    Hashimoto, K.4
  • 15
    • 0035096448 scopus 로고    scopus 로고
    • Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity
    • Katsuki H., Tomita M., Takenaka C., Shirakawa H., Shimazu S., Ibi M., Kume T., Kaneko S., Akaike A. Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity. J Neurochem. 76:2001;1336-1345.
    • (2001) J Neurochem , vol.76 , pp. 1336-1345
    • Katsuki, H.1    Tomita, M.2    Takenaka, C.3    Shirakawa, H.4    Shimazu, S.5    Ibi, M.6    Kume, T.7    Kaneko, S.8    Akaike, A.9
  • 16
    • 0031952528 scopus 로고    scopus 로고
    • Novel endogenous 1,2,3,4-tetrahydroisoquinoline derivatives: Uptake by dopamine transporter and activity to induce parkinsonism
    • Kawai H., Makino Y., Hirobe M., Ohta S. Novel endogenous 1,2,3,4-tetrahydroisoquinoline derivatives uptake by dopamine transporter and activity to induce parkinsonism. J Neurochem. 70:1998;745-751.
    • (1998) J Neurochem , vol.70 , pp. 745-751
    • Kawai, H.1    Makino, Y.2    Hirobe, M.3    Ohta, S.4
  • 17
    • 0034489105 scopus 로고    scopus 로고
    • Dopamine transporter and catechol-O-methyltransferase activities are required for the toxicity of 1-(3′4′-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline
    • Kawai H., Kotake Y., Ohta S. Dopamine transporter and catechol-O-methyltransferase activities are required for the toxicity of 1-(3′4′-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline. Chem Res Toxicol. 13:2000;1294-1301.
    • (2000) Chem Res Toxicol , vol.13 , pp. 1294-1301
    • Kawai, H.1    Kotake, Y.2    Ohta, S.3
  • 18
    • 0023011644 scopus 로고
    • Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain
    • Kohno M., Ohta S., Hirobe M. Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain. Biochem Biophys Res Commun. 140:1986;448-454.
    • (1986) Biochem Biophys Res Commun , vol.140 , pp. 448-454
    • Kohno, M.1    Ohta, S.2    Hirobe, M.3
  • 19
    • 0028850564 scopus 로고
    • 1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: A novel endogenous amine in mouse brain and parkinsonian CSF
    • Kotake Y., Tasaki Y., Makino Y., Ohta S., Hirobe M. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent a novel endogenous amine in mouse brain and parkinsonian CSF. J Neurochem. 65:1995;2633-2638.
    • (1995) J Neurochem , vol.65 , pp. 2633-2638
    • Kotake, Y.1    Tasaki, Y.2    Makino, Y.3    Ohta, S.4    Hirobe, M.5
  • 20
    • 0029806296 scopus 로고    scopus 로고
    • Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate
    • Kotake Y., Yoshida M., Ogawa M., Tasaki Y., Hirobe M., Ohta S. Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate. Neurosci Lett. 217:1996;69-71.
    • (1996) Neurosci Lett , vol.217 , pp. 69-71
    • Kotake, Y.1    Yoshida, M.2    Ogawa, M.3    Tasaki, Y.4    Hirobe, M.5    Ohta, S.6
  • 21
    • 0032559870 scopus 로고    scopus 로고
    • Deprenyl decreases an endogenous parkinsonism-inducing compound, 1-benzyl-1,2,3,4-tetrahydroisoquinoline in mice: In vivo and in vitro studies
    • Kotake Y., Tasaki Y., Hirobe M., Ohta S. Deprenyl decreases an endogenous parkinsonism-inducing compound, 1-benzyl-1,2,3,4-tetrahydroisoquinoline in mice in vivo and in vitro studies. Brain Res. 787:1998;341-343.
    • (1998) Brain Res , vol.787 , pp. 341-343
    • Kotake, Y.1    Tasaki, Y.2    Hirobe, M.3    Ohta, S.4
  • 23
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston J.W., Ballard P., Tetrud J.W., Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science. 219:1983;979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 25
    • 0031817082 scopus 로고    scopus 로고
    • Co-culture with the striatum attenuates N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of rat mesencephalic slice cultures
    • Maeda T., Ibi M., Shimazu S., Akaike A. Co-culture with the striatum attenuates N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of rat mesencephalic slice cultures. Jpn J Pharmacol. 77:1998;161-167.
    • (1998) Jpn J Pharmacol , vol.77 , pp. 161-167
    • Maeda, T.1    Ibi, M.2    Shimazu, S.3    Akaike, A.4
  • 27
    • 0031952527 scopus 로고    scopus 로고
    • Endogenously occurring β-carboline induces parkinsonism in nonprimate animals: A possible protoxin in idiopathic Parkinson's disease
    • Matsubara K., Gonda T., Sawada H., Uezono T., Kobayashi Y., Kawamura T., Ohtani K., Kimura K., Akaike A. Endogenously occurring β-carboline induces parkinsonism in nonprimate animals a possible protoxin in idiopathic Parkinson's disease. J Neurochem. 70:1998;727-735.
    • (1998) J Neurochem , vol.70 , pp. 727-735
    • Matsubara, K.1    Gonda, T.2    Sawada, H.3    Uezono, T.4    Kobayashi, Y.5    Kawamura, T.6    Ohtani, K.7    Kimura, K.8    Akaike, A.9
  • 30
    • 0030051311 scopus 로고    scopus 로고
    • Effect of dopamine, dimethoxyphenylethylamine, papaverine, and related compounds on mitochondrial respiration and complex I activity
    • Morikawa N., Nakagawa-Hattori Y., Mizuno Y. Effect of dopamine, dimethoxyphenylethylamine, papaverine, and related compounds on mitochondrial respiration and complex I activity. J Neurochem. 66:1996;1174-1181.
    • (1996) J Neurochem , vol.66 , pp. 1174-1181
    • Morikawa, N.1    Nakagawa-Hattori, Y.2    Mizuno, Y.3
  • 31
    • 0031706179 scopus 로고    scopus 로고
    • Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes
    • Morikawa N., Naoi M., Maruyama W., Ohta S., Kotake Y., Kawai H., Niwa T., Dostert P., Mizuno Y. Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes. J Neural Transm. 105:1998;677-688.
    • (1998) J Neural Transm , vol.105 , pp. 677-688
    • Morikawa, N.1    Naoi, M.2    Maruyama, W.3    Ohta, S.4    Kotake, Y.5    Kawai, H.6    Niwa, T.7    Dostert, P.8    Mizuno, Y.9
  • 32
    • 0023935663 scopus 로고
    • An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions
    • Nagatsu T., Yoshida M. An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions. Neurosci Lett. 87:1988;178-182.
    • (1988) Neurosci Lett , vol.87 , pp. 178-182
    • Nagatsu, T.1    Yoshida, M.2
  • 33
    • 0030840624 scopus 로고    scopus 로고
    • Isoquinoline neurotoxins in the brain and Parkinson's disease
    • Nagatsu T. Isoquinoline neurotoxins in the brain and Parkinson's disease. Neurosci Res. 29:1997;99-111.
    • (1997) Neurosci Res , vol.29 , pp. 99-111
    • Nagatsu, T.1
  • 35
    • 0023625261 scopus 로고
    • Tetrahydroisoquinoline and 1-methyltetrahydroisoquinoline are present in the human brain: Relation to Parkinson's disease
    • Ohta S., Kohno M., Makino Y., Tachikawa O., Hirobe M. Tetrahydroisoquinoline and 1-methyltetrahydroisoquinoline are present in the human brain relation to Parkinson's disease. Biomed Res. 8:1987;453-456.
    • (1987) Biomed Res , vol.8 , pp. 453-456
    • Ohta, S.1    Kohno, M.2    Makino, Y.3    Tachikawa, O.4    Hirobe, M.5
  • 36
    • 0031933355 scopus 로고    scopus 로고
    • Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells
    • Okada T., Shimada S., Sato K., Kotake Y., Kawai H., Ohta S., Tohyama M., Nishimura T. Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells. Neurosci Res. 30:1998;87-90.
    • (1998) Neurosci Res , vol.30 , pp. 87-90
    • Okada, T.1    Shimada, S.2    Sato, K.3    Kotake, Y.4    Kawai, H.5    Ohta, S.6    Tohyama, M.7    Nishimura, T.8
  • 37
    • 0025220949 scopus 로고
    • Rat ventral mesencephalon grown as organotypic slice cultures and co-cultured with striatum, hippocampus, and cerebellum
    • Østergaard K., Schou J.P., Zimmer J. Rat ventral mesencephalon grown as organotypic slice cultures and co-cultured with striatum, hippocampus, and cerebellum. Exp Brain Res. 82:1990;547-565.
    • (1990) Exp Brain Res , vol.82 , pp. 547-565
    • Østergaard, K.1    Schou, J.P.2    Zimmer, J.3
  • 38
    • 0025964041 scopus 로고
    • The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method
    • Pakkenberg B., Moller A., Gundersen H.J., Mouritzen-Dam A., Pakkenberg H. The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. J Neurol Neurosurg Psychiatry. 54:1991;30-33.
    • (1991) J Neurol Neurosurg Psychiatry , vol.54 , pp. 30-33
    • Pakkenberg, B.1    Moller, A.2    Gundersen, H.J.3    Mouritzen-Dam, A.4    Pakkenberg, H.5
  • 39
    • 0025281117 scopus 로고
    • Mechanisms of toxicity and cellular resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in adrenomedullary chromaffin cell cultures
    • Reinhard J.F. Jr, Carmichael S.W., Daniels A.J. Mechanisms of toxicity and cellular resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in adrenomedullary chromaffin cell cultures. J Neurochem. 55:1990;311-320.
    • (1990) J Neurochem , vol.55 , pp. 311-320
    • Reinhard J.F., Jr.1    Carmichael, S.W.2    Daniels, A.J.3
  • 40
    • 0022633481 scopus 로고
    • MPTP: A neurotoxin relevant to the pathophysiology of Parkinson's disease
    • Snyder S.H., D'Amato R.J. MPTP a neurotoxin relevant to the pathophysiology of Parkinson's disease. Neurology. 36:1986;250-258.
    • (1986) Neurology , vol.36 , pp. 250-258
    • Snyder, S.H.1    D'Amato, R.J.2
  • 41
    • 0001216675 scopus 로고
    • MK-801 fails to protect against the dopaminergic neuropathology produced by systemic MPTP in mice or intranigral MPTP in rats
    • Sonsalla P.K., Zeevalk G.D., Manzino L., Giovani A., Nicklas W.J. MK-801 fails to protect against the dopaminergic neuropathology produced by systemic MPTP in mice or intranigral MPTP in rats. J Neurochem. 58:1992;398-400.
    • (1992) J Neurochem , vol.58 , pp. 398-400
    • Sonsalla, P.K.1    Zeevalk, G.D.2    Manzino, L.3    Giovani, A.4    Nicklas, W.J.5
  • 42
    • 0027177628 scopus 로고
    • +) nigral toxicity in the rat by prior decortication or MK-801 treatment: A stereological estimate of neuronal loss
    • +) nigral toxicity in the rat by prior decortication or MK-801 treatment a stereological estimate of neuronal loss. Neurobiol Aging. 14:1993;295-301.
    • (1993) Neurobiol Aging , vol.14 , pp. 295-301
    • Srivastava, R.1    Brouillet, E.2    Beal, M.F.3    Storey, E.4    Hyman, B.T.5
  • 43
    • 0028827068 scopus 로고
    • Electrophysiological characterization of dopaminergic and non-dopaminergic neurones in organotypic slice cultures of the rat ventral mesencephalon
    • Steensen B.H., Nedergaard S., Østergaard K., Lambert J.D.C. Electrophysiological characterization of dopaminergic and non-dopaminergic neurones in organotypic slice cultures of the rat ventral mesencephalon. Exp Brain Res. 106:1995;205-214.
    • (1995) Exp Brain Res , vol.106 , pp. 205-214
    • Steensen, B.H.1    Nedergaard, S.2    Østergaard, K.3    Lambert, J.D.C.4
  • 44
    • 0033958942 scopus 로고    scopus 로고
    • 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism
    • Storch A., Kaftan A., Burkhardt K., Schwarz J. 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism. Brain Res. 855:2000;67-75.
    • (2000) Brain Res , vol.855 , pp. 67-75
    • Storch, A.1    Kaftan, A.2    Burkhardt, K.3    Schwarz, J.4
  • 46
    • 0028902855 scopus 로고
    • Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation
    • Strasser U., Fischer G. Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation. J Neurosci Methods. 57:1995;177-186.
    • (1995) J Neurosci Methods , vol.57 , pp. 177-186
    • Strasser, U.1    Fischer, G.2
  • 47
    • 0025718695 scopus 로고
    • 1-Methyl-1,2,3,4-tetrahydroisoquinoline, decreasing in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse, prevents parkinsonism-like behavior abnormalities
    • Tasaki Y., Makino Y., Ohta S., Hirobe M. 1-Methyl-1,2,3,4-tetrahydroisoquinoline, decreasing in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse, prevents parkinsonism-like behavior abnormalities. J Neurochem. 57:1991;1940-1943.
    • (1991) J Neurochem , vol.57 , pp. 1940-1943
    • Tasaki, Y.1    Makino, Y.2    Ohta, S.3    Hirobe, M.4
  • 48
    • 0027504297 scopus 로고
    • Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
    • Tipton K.F., Singer T.P. Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J Neurochem. 61:1993;1191-1206.
    • (1993) J Neurochem , vol.61 , pp. 1191-1206
    • Tipton, K.F.1    Singer, T.P.2
  • 50
    • 0026047370 scopus 로고
    • Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures
    • Vornov J.J., Tasker R.C., Coyle J.T. Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures. Exp Neurol. 114:1991;11-22.
    • (1991) Exp Neurol , vol.114 , pp. 11-22
    • Vornov, J.J.1    Tasker, R.C.2    Coyle, J.T.3
  • 51
    • 0026806604 scopus 로고
    • Laminar specificity of extrinsic cortical connections studied in coculture preparations
    • Yamamoto N., Yamada K., Kurotani T., Toyama K. Laminar specificity of extrinsic cortical connections studied in coculture preparations. Neuron. 9:1992;217-228.
    • (1992) Neuron , vol.9 , pp. 217-228
    • Yamamoto, N.1    Yamada, K.2    Kurotani, T.3    Toyama, K.4
  • 52
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides
    • Yankner B.A., Duffy L.K., Kirschner D.A. Neurotrophic and neurotoxic effects of amyloid beta protein reversal by tachykinin neuropeptides. Science. 250:1990;279-282.
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3
  • 53
    • 0024993985 scopus 로고
    • Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline: The behavioral and biochemical changes
    • Yoshida M., Niwa T., Nagatsu T. Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline the behavioral and biochemical changes. Neurosci Lett. 119:1990;109-111.
    • (1990) Neurosci Lett , vol.119 , pp. 109-111
    • Yoshida, M.1    Niwa, T.2    Nagatsu, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.