Use of stable isotope labeled probes to facilitate liquid chromatography/mass spectrometry based highthroughput screening of time-dependent CYP inhibitors

Rapid Communications in Mass Spectrometry

Volumn 24, Issue 15, 2010, Pages 2177-2185

  Dasgupta, Malini ^a   Tang, Weimin ^a   Caldwell, Gary W ^a   Yan, Zhengyin ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; ENZYME ACTIVITY; ENZYME INHIBITION; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROBES; SUBSTRATES;

ENZYMES ACTIVITY; HIGH THROUGHPUT SCREENING; HUMAN LIVER MICROSOMES; LC-MS-MS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MS/MS ANALYSIS; PRE-INCUBATION; STABLE ISOTOPES; TIME DEPENDENT;

METABOLITES;

CYTOCHROME P450 INHIBITOR; ENZYME INHIBITOR;

CHEMISTRY; ENZYMOLOGY; EVALUATION STUDY; HIGH THROUGHPUT SCREENING; HUMAN; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; PROCEDURES; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME INHIBITORS; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ISOTOPE LABELING; MICROSOMES, LIVER; TANDEM MASS SPECTROMETRY;

EID: 77955117355     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.4610     Document Type: Article

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