Evidence that newly synthesized esterified cholesterol is deposited in existing cytoplasmic lipid inclusions

Journal of Lipid Research

Volumn 42, Issue 5, 2001, Pages 768-777

  Kellner Weibel, Ginny ^a   McHendry Rinde, Barbara ^b   Page Haynes, M ^c   Adelman, Steven ^d  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b PFIZER INC   (United States)

^c YALE UNIVERSITY   (United States)

^d WYETH AYERST RESEARCH   (United States)

Author keywords

Hepatoma; Lipase; Lipid droplet; Triglyceride

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; ENZYME INHIBITOR; FAT DROPLET; OLEIC ACID; PHOSPHOLIPID; TRIACYLGLYCEROL;

ANIMAL CELL; ANISOTROPY; ARTICLE; CELL INCLUSION; CHOLESTEROL SYNTHESIS; CRYSTAL; CULTURE MEDIUM; FLOW CYTOMETRY; HYDROLYSIS; LIPID STORAGE; LIQUID; LIVER CELL CARCINOMA; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CHOLESTEROL ESTERASE; CHOLESTEROL ESTERS; ENZYME INHIBITORS; ESTERIFICATION; FLOW CYTOMETRY; HUMANS; HYDROLYSIS; INCLUSION BODIES; LIPID METABOLISM; MODELS, BIOLOGICAL; OLEIC ACID; ORGANOPHOSPHORUS COMPOUNDS; RATS; TRIGLYCERIDES; TUMOR CELLS, CULTURED; UMBELLIFERONES;

EID: 0034990367     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Chemical and physicochemical comparison of advanced atherosclerotic lesions of similar size and cholesterol content in cholesterol-fed New Zealand white and Watanabe heritable hyperlipidemic rabbits
2. Characterization of two unique cholesterol-rich lipid particles isolated from human aterhosclerosis lesions
3. Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions
4. Production of cholesteryl ester-rich anisotropic inclusions by mammalian cells in culture
5. Lipid composition and physical state effects on cellular cholesteryl ester clearence
6. Physical state of cholesteryl esters deposited in cultured macrophages
7. Analysis of the physical state of cholesteryl esters in arterial-smooth-muscle-derived foam cells by differential scanning calorimetry
8. The phase behavior of cholesteryl esters in intracellular inclusions
9. Smooth microsomes: A trap for cholesteryl ester formed in hepatic microsomes
10. Phospholipid synthesis in a membrane fraction associated with mitochondria
11. Membrane and plasma lipoproteins-bilayer-to-emulsion and emulsion-to-bilayer
12. Mechanisms of lipid-body formation
13. Isolation and partial characterization of the lipid phases of human atherosclerotic plaques
14. Physical state of cholesteryl esters deposited in cultured macrophages
15. The storage lipids in Tangier disease. A physical chemical study
16. Cellular cholesterol ester accumulation induced by free cholesterol-rich lipid dispersions
17. Preparation of delipidized serum protein for use in cell culture systems
18. A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells
19. Evidence that a neutral cholesteryl ester hydrolase is responsible for the extralysosomal hydrolysis of high-density lipoprotein cholesteryl ester in rat hepatoma cells (Fu5AH)
20. Cholesteryl ester hydrolysis in J774 macrophages occurs in the cytoplasm and lysosomes
21. Assembly of very low density lipoprotein in the hepatocyte
22. Triglyceride and cholesteryl ester hydrolysis in a cell culture model of smooth muscle foam cells
23. Light-scattering polarization measurements as a new parameter in flow cytometry
24. Post-translational regulation of perilipin expression
25. A rapid method of total lipid extraction and purification
26. The physical state of lipids of biological importance: Cholesteryl esters, cholesterol, triglycerides
27. Interaction of cholesterol ester and triglyceride in human plasma very low density lipoprotein
28. Thermal properties of systems containing cholesteryl esters and triglycerides
29. Factors underlying the variability of lipid droplet fluorescence in MA-10 Leydig tumor cells
30. Pyrene dodecanoic acid coenzyme A ester:peroxisomal oxidation and chain shortening
31. Spectrofluorometric measurements of the dispersion state of pyrenedodecanoic acid and its uptake by cultured cells and liposomes
32. Induction of lipid storage in cultured leukemic myeloid cells by pyrene-dodecanoic acid
33. Transport of fluorescent derivatives of fatty acids into cultured human leukemic myeloid cells and their subsequent metabolic utilization
34. The cholesteryl ester cycle in macrophage foam cells: Continual hydrolysis and reesterification of cytoplasmic cholesteryl esters
35. Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells
36. Perilipin: Unique proteins associated with intracellular neutral lipid droplets in adipocytes and steroidogenic cells
37. The lipid-rich core region of human atherosclerotic fibrous plaques
38. Cholesteryl ester-rich inclusions from human aortic fatty streak and fibrous plaque lesions of atherosclerosis
39. Cellular cholesteryl ester clearance: Relationship to the physical state of cholesteryl ester inclusions
40. Morphological characterization of the cholesteryl ester cycle in cultured mouse macrophage foam cells
41. Intracellular events in the "selective" transport of lipoprotein-derived cholesteryl esters
42. The participation of sterol carrier protein-2 in the conversion of cholesterol to cholesterol ester by rat liver microsomes
43. Effect of okadaic acid on utilization of lipoprotein-derived cholesteryl esters by rat steroidogenic cells
44. Intracellular cholesterol transport
45. Peroxisomes and sterol carrier protein-2 in luteal cell steroidogenesis: A possible role in cholesterol transport from lipid droplets to mitochondria
46. Physical-chemical basis of lipid deposition in atherosclerosis