The number and not the molecular structure of DNA double-strand breaks is more important for the formation of chromosomal aberrations: A hypothesis

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 701, Issue 1, 2010, Pages 3-11

  Obe, Guenter ^a   Johannes, Christian ^b   Ritter, Sylvia ^c  

^a Genetics Department ^*  (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c GSI HELMHOLTZZENTRUM FÜR SCHWERIONENFORSCHUNG GMBH   (Germany)

Author keywords

Chromosomal aberrations; DNA double strand breaks; Endonucleases; F Ratio; False sister chromatid exchanges

Indexed keywords

BENZON NUCLEASE; BLEOMYCIN; DEOXYRIBONUCLEASE I; ENDONUCLEASE; MESYLIC ACID METHYL ESTER; MITOMYCIN C; RESTRICTION ENDONUCLEASE; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE; UNCLASSIFIED DRUG; ZINOSTATIN; MUTAGENIC AGENT;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELLULAR DISTRIBUTION; CENTROMERE; CHO CELL; CHROMATID ABERRATION; CHROMATID EXCHANGE; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; DICENTRIC CHROMOSOME; DNA STRUCTURE; DOUBLE MINUTE CHROMOSOME; DOUBLE STRANDED DNA BREAK; ELECTROPORATION; ENZYME ANALYSIS; GENOTOXICITY; HUMAN; INTERSTITIAL CHROMOSOME DELETION; IONIZING RADIATION; LINEAR ENERGY TRANSFER; METAPHASE; NEUROSPORA CRASSA; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RING CHROMOSOME; SISTER CHROMATID EXCHANGE; ULTRAVIOLET RADIATION; X RAY; ANIMAL; BIOLOGICAL MODEL; METABOLISM;

ANIMALS; CHROMOSOME ABERRATIONS; DNA BREAKS, DOUBLE-STRANDED; ENDONUCLEASES; HUMANS; MODELS, GENETIC; MUTAGENS; RADIATION, IONIZING; SISTER CHROMATID EXCHANGE;

EID: 77955094689     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.05.010     Document Type: Article

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