Frequencies of polycentric chromosomes following combinational treatments of Chinese hamster ovary cells with restriction endonucleases and X-ray, bleomycin or DNase I

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 373, Issue 2, 1997, Pages 237-244

  Johannes, Christian ^a   Heller, Wolf Dieter ^b   Eke, Petra ^a   Obe, Günter ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Bleomycin; CHO; DNase I; Polycentric chromosome; Restriction endonuclease; X ray

Indexed keywords

BLEOMYCIN; DEOXYRIBONUCLEASE I; RESTRICTION ENDONUCLEASE;

ANIMAL CELL; ARTICLE; CHO CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; DICENTRIC CHROMOSOME; DNA STRAND BREAKAGE; NONHUMAN; PRIORITY JOURNAL; X RAY;

ANIMALS; BLEOMYCIN; CHO CELLS; CHROMOSOME ABERRATIONS; CHROMOSOMES; CRICETINAE; DEOXYRIBONUCLEASE ECORI; DEOXYRIBONUCLEASE I; DNA RESTRICTION ENZYMES; DRUG SYNERGISM;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0030697270     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00202-3     Document Type: Article

References (14)

1. Pfeiffer, P., Thode, S., Hancke, J., Keohavong, P. and Thilly, W.G. (1994) Resolution and conservation of mismatches in DNA end joining, Mutagenesis, 9, 527-535.
2. Johannes, C. and Obe, G. (1994) Combination treatments of Chinese hamster ovary cells with various restriction endonucleases result in chromosomal aberrations whose frequencies are additive or less than additive, Mutation Res., 309, 211-217.
3. Yates, B.L. and Morgan, W.F. (1993) Nonhomologous DNA end rejoining in chromosomal aberration formation, Mutation Res., 285, 53-60.
4. Ortiz, T., Piñeiro, J. and Cortés, F. (1995) Chromosome damage induced by combined treatments with restriction endonucleases introduced into CHO cells by single or double electroporation, Mutation Res., 327, 161-169.
5. Tanzarella, C., De Salvia, R., Degrassi, F., Fiore, M. and Palitti, F. (1990) Interaction between X-ray- and restriction endonuclease-induced lesions in the formation of chromosomal aberrations. Mutation Res., 244, 197-200.
6. Morgan, W.F., Yates, B.L., Rufer, J.T., Abella Columna, E., Valcarel, E.R. and Phillips, J.W. (1991) Chromosomal aberration induction in CHO cells by combined exposure to restriction enzymes and X-rays, Int. J. Radiat. Biol., 60, 627-634.
7. Obe, G., Johannes, C. and Schulte-Frohlinde, D. (1992) DNA double-strand breaks induced by sparsely ionizing radiation and endonucleases as critical lesions for cell death, chromosomal aberrations, mutations and oncogenic transformation, Mutagenesis, 7, 3-12.
8. Povirk, L.F. and Austin, M.J.F. (1991) Genotoxicity of bleomycin. Mutation Res., 257, 127-143.
9. Johannes, C., Boes, R. and Obe, G. (1992) Uptake of the restriction endonuclease AluI by Chinese hamster ovary cells measured by frequencies of induced chromosomal aberrations: effect of hypertonic concentrations of glycerol and sorbitol, Mutagenesis, 7, 225-232.
10. Hill, A. and Wolff, S. (1982) Increased induction of sister chromatid exchanges by diethylstilbestrol in lymphocytes from pregnant and premenopausal women, Cancer Res., 42, 893-896.
11. Johannes, C. and Obe, G. (1991) Induction of chromosomal aberrations with the restriction endonuclease AluI in Chinese hamster ovary cells: comparison of different treatment methods, Int. J. Radiat. Biol, 59, 1379-1393.
12. Kessler, C. (1987) Class II restriction endonucleases. In: Obe, G. and Basler, A. (Eds.), Cytogenetics, Basic and Applied Aspects. Springer, Berlin, pp. 225-279.
13. Boes, R. and Obe, G. (1993) Scrape-loading: A simple method to induce chromosomal aberrations with restriction enzymes in CHO cells, Mutation Res., 292, 225-230.
14. Weissenborn, U., Johannes, C., Raesfeld, C. and Obe, G. (1994) Potentiation of the cytogenetic effects of bleomycin in mammalian cells by membrane permeabilization, Biol. Zent. Bl., 113, 53-67.