메뉴 건너뛰기




Volumn 701, Issue 1, 2010, Pages 92-97

Relation between DNA repair, apoptosis and chromosomal aberrations in presence of pifithrin-α, an inhibitor of p53

Author keywords

Apoptosis; Chromosomal aberrations; DNA repair; HPBL; P53; Pifithrin

Indexed keywords

BROXURIDINE; PHOSPHATE BUFFERED SALINE; PHYTOHEMAGGLUTININ; PIFITHRIN ALPHA; PROTEIN P53; BENZOTHIAZOLE DERIVATIVE; PIFITHRIN; TOLUENE;

EID: 77955093935     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.03.017     Document Type: Article
Times cited : (9)

References (37)
  • 1
    • 9244224723 scopus 로고    scopus 로고
    • Intrinsic tumour suppression
    • Lowe S.W., Cepero E., Evan G. Intrinsic tumour suppression. Nature 2004, 432:307-315.
    • (2004) Nature , vol.432 , pp. 307-315
    • Lowe, S.W.1    Cepero, E.2    Evan, G.3
  • 2
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: the growing complexity of p53
    • Vousden K.H., Prives C. Blinded by the light: the growing complexity of p53. Cell 2009, 137:413-431.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 3
    • 11844293427 scopus 로고    scopus 로고
    • P53 and prognosis: new insights and further complexity
    • Vousden K.H., Prives C. p53 and prognosis: new insights and further complexity. Cell 2005, 120:7-10.
    • (2005) Cell , vol.120 , pp. 7-10
    • Vousden, K.H.1    Prives, C.2
  • 4
    • 0026801977 scopus 로고
    • Wild type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
    • Yin Y, Tainsky M.A., Bishoff F.Z., Strong L.C., Wahl G.M. Wild type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 1992, 70:937-944.
    • (1992) Cell , vol.70 , pp. 937-944
    • Yin, Y.1    Tainsky, M.A.2    Bishoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5
  • 6
    • 0031003552 scopus 로고    scopus 로고
    • Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo
    • Komarova E.A., Chernov M.V., Franks R., Wang K., Armin G., Zelnick C.R., Chin D.M., Bacus S.S., Stark G.R., Gudkov A.V. Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J. 1997, 16:1391-1400.
    • (1997) EMBO J. , vol.16 , pp. 1391-1400
    • Komarova, E.A.1    Chernov, M.V.2    Franks, R.3    Wang, K.4    Armin, G.5    Zelnick, C.R.6    Chin, D.M.7    Bacus, S.S.8    Stark, G.R.9    Gudkov, A.V.10
  • 7
    • 0000051538 scopus 로고    scopus 로고
    • Could p53 be a target for therapeutic suppression? Semin
    • Komarova E.A., Gudkov A.V. Could p53 be a target for therapeutic suppression? Semin. Cancer Biol. 1998, 8:389-400.
    • (1998) Cancer Biol. , vol.8 , pp. 389-400
    • Komarova, E.A.1    Gudkov, A.V.2
  • 9
    • 0036207910 scopus 로고    scopus 로고
    • Normal breast epithelial cells induce p53-dependent apoptosis and p53-independent cell cycle arrest of breast cancer cells
    • Toillon R.A., Chopin V., Jouy N., Fauquette W., Boilly B., Le Bourthis X. Normal breast epithelial cells induce p53-dependent apoptosis and p53-independent cell cycle arrest of breast cancer cells. Breast Cancer Res. Treat. 2002, 71:269-280.
    • (2002) Breast Cancer Res. Treat. , vol.71 , pp. 269-280
    • Toillon, R.A.1    Chopin, V.2    Jouy, N.3    Fauquette, W.4    Boilly, B.5    Le Bourthis, X.6
  • 10
    • 0037051786 scopus 로고    scopus 로고
    • Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in C141 cells
    • Zhang Z., Huang C., Li J., Shi X. Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in C141 cells. J. Inorg. Biochem. 2002, 89:142-148.
    • (2002) J. Inorg. Biochem. , vol.89 , pp. 142-148
    • Zhang, Z.1    Huang, C.2    Li, J.3    Shi, X.4
  • 11
    • 0037087629 scopus 로고    scopus 로고
    • Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3-dependent development and tumorigenesis
    • Pani L., Horal M., Loeken M.R. Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3-dependent development and tumorigenesis. Genes. Dev. 2002, 16:676-680.
    • (2002) Genes. Dev. , vol.16 , pp. 676-680
    • Pani, L.1    Horal, M.2    Loeken, M.R.3
  • 12
    • 0037133649 scopus 로고    scopus 로고
    • Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons
    • Alves da Costa C., Paitel E., Mattson M.P., Amson R., Telerman A., Ancolio K., Checler F. Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons. Proc. Natl. Acad. Sci. USA 2002, 99:4043-4048.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 4043-4048
    • Alves da Costa, C.1    Paitel, E.2    Mattson, M.P.3    Amson, R.4    Telerman, A.5    Ancolio, K.6    Checler, F.7
  • 13
    • 0036962164 scopus 로고    scopus 로고
    • Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism
    • Shih A., Davis F.B., Lin H.Y., Davis P.J. Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism. J. Clin. Endocrinol. Metab. 2002, 87:1223-1232.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 1223-1232
    • Shih, A.1    Davis, F.B.2    Lin, H.Y.3    Davis, P.J.4
  • 14
    • 0036494570 scopus 로고    scopus 로고
    • Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine
    • Havre P.A., O'Reilly S., McCormick J.J., Brash D.E. Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine. Cancer Res. 2002, 62:1443-1449.
    • (2002) Cancer Res. , vol.62 , pp. 1443-1449
    • Havre, P.A.1    O'Reilly, S.2    McCormick, J.J.3    Brash, D.E.4
  • 15
    • 0037138454 scopus 로고    scopus 로고
    • Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro
    • Bassi L., Carloni M., Fonti E., Palma de la Pena N., Meschini R., Palitti F. Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro. Mutat. Res. 2002, 499:163-176.
    • (2002) Mutat. Res. , vol.499 , pp. 163-176
    • Bassi, L.1    Carloni, M.2    Fonti, E.3    Palma de la Pena, N.4    Meschini, R.5    Palitti, F.6
  • 16
    • 0036152740 scopus 로고    scopus 로고
    • Sodium butyrate induces p53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells
    • Chopin V., Toillon R.A., Jouy N., Le Bourhis X. Sodium butyrate induces p53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells. Br. J. Pharmacol. 2002, 135:79-86.
    • (2002) Br. J. Pharmacol. , vol.135 , pp. 79-86
    • Chopin, V.1    Toillon, R.A.2    Jouy, N.3    Le Bourhis, X.4
  • 17
    • 0037192824 scopus 로고    scopus 로고
    • Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism
    • Lorenzo E., Ruiz-Ruiz C., Quesada A.J., Hernandez G., Rodriguez A., Lopez-Rivas A., Redondo J.M. Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. J. Biol. Chem. 2002, 277:10883-10892.
    • (2002) J. Biol. Chem. , vol.277 , pp. 10883-10892
    • Lorenzo, E.1    Ruiz-Ruiz, C.2    Quesada, A.J.3    Hernandez, G.4    Rodriguez, A.5    Lopez-Rivas, A.6    Redondo, J.M.7
  • 18
    • 0035821788 scopus 로고    scopus 로고
    • P21 Waf1/Cip1 can protect human colon carcinoma cells p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents
    • Mahyar-Roemer M., Roemer K. p21 Waf1/Cip1 can protect human colon carcinoma cells p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents. Oncogene 2001, 20:3387-3398.
    • (2001) Oncogene , vol.20 , pp. 3387-3398
    • Mahyar-Roemer, M.1    Roemer, K.2
  • 19
    • 0035874884 scopus 로고    scopus 로고
    • C-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo
    • Arango D., Corner G.A., Wadler S., Catalano P.J., Augenlicht L.H. c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo. Cancer Res. 2001, 61:4910-4915.
    • (2001) Cancer Res. , vol.61 , pp. 4910-4915
    • Arango, D.1    Corner, G.A.2    Wadler, S.3    Catalano, P.J.4    Augenlicht, L.H.5
  • 20
    • 0035943738 scopus 로고    scopus 로고
    • Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes
    • Lakkaraju A., Dubinsky J.M., Low W.C., Rahman Y.E. Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. J. Biol. Chem. 2001, 276:32000-32007.
    • (2001) J. Biol. Chem. , vol.276 , pp. 32000-32007
    • Lakkaraju, A.1    Dubinsky, J.M.2    Low, W.C.3    Rahman, Y.E.4
  • 21
    • 0035085210 scopus 로고    scopus 로고
    • A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide
    • Culmsee C., Zhu X., Yu Q.S., Chan S.L., Camandola S., Guo Z., Greig N.H., Mattson M.P. A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J. Neurochem. 2001, 77:220-228.
    • (2001) J. Neurochem. , vol.77 , pp. 220-228
    • Culmsee, C.1    Zhu, X.2    Yu, Q.S.3    Chan, S.L.4    Camandola, S.5    Guo, Z.6    Greig, N.H.7    Mattson, M.P.8
  • 22
    • 0033632162 scopus 로고    scopus 로고
    • Suppression of p53: a new approach to overcome side effects of antitumour
    • Komarova E.A., Gudkov A.V. Suppression of p53: a new approach to overcome side effects of antitumour. Biochem. (Moscow) 2000, 65:41-48.
    • (2000) Biochem. (Moscow) , vol.65 , pp. 41-48
    • Komarova, E.A.1    Gudkov, A.V.2
  • 23
    • 0033552636 scopus 로고    scopus 로고
    • Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53
    • Albrechtsen N., Dornreiter I., Grosse F., Kim E., Wiesmuller L., Deppert W. Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53. Oncogene 1999, 18:7706-7717.
    • (1999) Oncogene , vol.18 , pp. 7706-7717
    • Albrechtsen, N.1    Dornreiter, I.2    Grosse, F.3    Kim, E.4    Wiesmuller, L.5    Deppert, W.6
  • 24
    • 2442477786 scopus 로고    scopus 로고
    • P53's double life: transactivation-independent repression of homologous recombination
    • Bertrand P., Saintigny Y., Lopez B.S. P53's double life: transactivation-independent repression of homologous recombination. Trends Genet. 2004, 20:235-243.
    • (2004) Trends Genet. , vol.20 , pp. 235-243
    • Bertrand, P.1    Saintigny, Y.2    Lopez, B.S.3
  • 25
    • 11244344381 scopus 로고    scopus 로고
    • P53: traffic cop at the crossroads of DNA repair and recombination
    • Sengupta S., Harris C.C. p53: traffic cop at the crossroads of DNA repair and recombination. Nat. Rev. Mol. Cell Biol. 2005, 6:44-55.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 44-55
    • Sengupta, S.1    Harris, C.C.2
  • 27
    • 0016328318 scopus 로고
    • New Giemsa method for the differential staining of sister chromatids
    • Perry P., Wolff S. New Giemsa method for the differential staining of sister chromatids. Nature 1974, 251:156-158.
    • (1974) Nature , vol.251 , pp. 156-158
    • Perry, P.1    Wolff, S.2
  • 29
    • 77449156471 scopus 로고    scopus 로고
    • In situ localization of apoptosis using tunnel
    • Hewitson T.D., Darby I.A. In situ localization of apoptosis using tunnel. Methods Mol. Biol. 2010, 611:161-170.
    • (2010) Methods Mol. Biol. , vol.611 , pp. 161-170
    • Hewitson, T.D.1    Darby, I.A.2
  • 30
    • 0017252257 scopus 로고
    • Classification and relationships of induced chromosomal structural changes
    • Savage J.R.K. Classification and relationships of induced chromosomal structural changes. J. Med. Genet. 1975, 13:103-122.
    • (1975) J. Med. Genet. , vol.13 , pp. 103-122
    • Savage, J.R.K.1
  • 32
    • 0742269803 scopus 로고    scopus 로고
    • X-irradiated human lymphocytes with unstable aberrations and their preferential elimination by p53/survivin-dependent apoptosis
    • Bassi L., Carloni M., Meschini R., Fonti E., Palitti F. X-irradiated human lymphocytes with unstable aberrations and their preferential elimination by p53/survivin-dependent apoptosis. Int. J. Radiat. Biol. 2003, 79:943-954.
    • (2003) Int. J. Radiat. Biol. , vol.79 , pp. 943-954
    • Bassi, L.1    Carloni, M.2    Meschini, R.3    Fonti, E.4    Palitti, F.5
  • 33
    • 0027507626 scopus 로고
    • Mechanism of chromosome exchange formation in human fibroblasts: insights from "chromosome painting"
    • Brown J.M., Evans J.W., Kovacs M.S. Mechanism of chromosome exchange formation in human fibroblasts: insights from "chromosome painting". Environ. Mol. Mutat. 1993, 22:218-224.
    • (1993) Environ. Mol. Mutat. , vol.22 , pp. 218-224
    • Brown, J.M.1    Evans, J.W.2    Kovacs, M.S.3
  • 34
    • 0029612225 scopus 로고
    • Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends
    • Lobrich M., Rydberg B., Cooper P.K. Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends. Proc. Natl. Acad. Sci. USA 1995, 92:12050-12054.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 12050-12054
    • Lobrich, M.1    Rydberg, B.2    Cooper, P.K.3
  • 36
    • 0022992648 scopus 로고
    • Cell survival and radiation induced chromosome aberrations. II. Experimental findings in human lymphocytes analysed in first and second post-irradiation metaphases
    • Bauchinger M., Schimid E., Braselmann H. Cell survival and radiation induced chromosome aberrations. II. Experimental findings in human lymphocytes analysed in first and second post-irradiation metaphases. Radiat. Environ. Biophys. 1986, 25:253-260.
    • (1986) Radiat. Environ. Biophys. , vol.25 , pp. 253-260
    • Bauchinger, M.1    Schimid, E.2    Braselmann, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.