The hemodynamic effects of medetomidine continuous rate infusions in the dog

Veterinary Anaesthesia and Analgesia

Volumn 37, Issue 3, 2010, Pages 197-206

  Carter, Jennifer E ^a   Campbell, Nigel B ^a   Posner, Lysa P ^a   Swanson, Cliff ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Cardiac output; CRI; Medetomidine

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

EID: 77955064372     PISSN: 14672987     EISSN: 14672995     Source Type: Journal    
DOI: 10.1111/j.1467-2995.2009.00522.x     Document Type: Article

References (26)

1. Ambrisko TD, Hikasa Y, Sato K. Influence of medetomidine on stress-related neurohormonal and metabolic effects caused by butorphanol, fentanyl and ketamine administration in dogs. Am J Vet Res 2005, 66:406-412.
2. Bein G, Meybohm P, Cavus E. The reliability of pulse contour-derived cardiac output during hemorrhage and after vasopressor administration. Anesth Analg 2007, 105:107-113.
3. Bloor B, Frankland M, Alper G. Haemodynamic and sedative effects of dexmedetomidine in dog. J Pharmacol Exp Ther 1992, 263:690-697.
4. Duffy AL, Butler AL, Radecki SV. Comparison of continuous arterial pressure waveform analysis with the lithium dilution technique to monitor cardiac output in conscious dogs with systemic inflammatory response syndrome. Am J Vet Res 2009, 70:1365-1373.
5. Ebert TJ, Hall JE, Barney JA. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anaesthesiology 2000, 93:382-394.
6. Enouri SS, Kerr CL, McDonell WN. Effects of a peripheral alpha-2 adrenergic-receptor antagonist on the hemodynamic changes induced by medetomidine administration in conscious dogs. Am J Vet Res 2008, 69:728-736.
7. Flacke JW, Flacke WE, Bloor BC. Hemodynamic effects of dexmedetomidine, an alpha 2-adrenergic agonist, in autonomically denervated dogs. J Cardiovasc Pharmacol 1990, 16:616-623.
8. Flacke W, Flacke J, Bloor B. Effects of dexmedetomidine on systemic and coronary haemodynamics in the anesthetized dog. J Cardiothorac Vasc Anesth 1993, 7:41-49.
9. Grimm KA, Tranquilli WJ, Gross DR. Cardiopulmonary effects of fentanyl in conscious dogs and dogs sedated with a continuous rate infusion of medetomidine. Am J Vet Res 2005, 66:1222-1226.
10. Honkavaara JM, Raekallio MR, Kuusela EK. The effects of L-659,066, a peripheral alpha-2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs. Vet Anaesth Analg 2008, 35:409-413.
11. Housmans P. Effects of dexmedetomidine on contractility, relaxation and intracellular calcium transients of isolated ventricular myocardium. Anesthesiology 1990, 73:919-922.
12. Ko J, Fox S, Mandsager R. Sedative and cardiorespiratory effects of medetomidine, medetomidine-butorphanol, and medetomidine-ketamine in dogs. J Vet Med Assoc 2000, 216:1578-1583.
13. Kuo WC, Keegan RD. Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. Am J Vet Res 2004, 65:931-937.
14. Kuusela E, Raekallio M, Antilla M. Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs. J Vet Pharmacol Ther 2000, 23:15-20.
15. Maze M, Tranquilli W. Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology 1991, 74:581-605.
16. de Morais HS, Muir WW. The effects of medetomidine on cardiac contractility in autonomically blocked dogs. Vet Surg 1995, 24:356-364.
17. Ossipov M, Harris S, Lloyd P. Antinociceptive interaction between opioids and medetomidine: systemic additivity and spinal synergy. Anesthesiology 1990, 73:1227-1235.
18. Pascoe PJ. The cardiovascular effects of dexmedetomidine given by continuous infusion during isoflurane anesthesia in dogs. Vet Anaesth Analg 2005, 32:9. abstract
19. Pascoe PJ, Raekallio M, Kuusela E. Changes in the minimum alveolar concentration of isoflurane and some cardiopulmonary measurements during three continuous infusion rates of dexmedetomidine in dogs. Vet Anaesth Analg 2006, 33:39-103.
20. Pittman J, Bar-Yosef S, Sumping J. Continuous cardiac output monitoring with pulse contour analysis: a comparison with lithium indicator dilution cardiac output measurement. Crit Care Med 2005, 33:2015-2021.
21. Pypendop B, Verstegen J. Hemodynamic effects of medetomidine in the dog: a dose titration study. Vet Surg 1998, 27:612-622.
22. Rhodes A, Sunderland R. Arterial pulse power analysis: the LiDCO™ plus system. Functional Hemodynamic Monitoring: Update in Intensive Care and Emergency Medicine 2005, 183-192. Pinksy MR, Payen D. eds, Springer-Verlag, Heidelberg, Germany, pp
23. Savola JM. Cardiovascular actions of medetomidine and their reversal by atipamezole. Acta Vet Scand 1989, 85(Suppl):39-47.
24. Schauvliege S, Van den Eege A, Duchateau L. Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs. Vet Anaesth Analg 2009, 36:197-208.
25. Valtonlina C, Robben JH, Uilenreef J. Clinical evaluation of the efficacy and safely of a constant rate infusion of dexmedetomidine for postoperative pain management in dogs. Vet Anaesth Analg 2009, 36:369-383.
26. Virtanen R. Pharmacologic profiles of medetomidine and its antagonist atipamezole. Acta Vet Scand 1989, 85:85-88.